{"id":"nt-201","safety":{"commonSideEffects":[{"rate":"7-15","effect":"Headache"},{"rate":"5-10","effect":"Injection site pain or bruising"},{"rate":"1-3","effect":"Eyelid ptosis"},{"rate":"1-2","effect":"Brow ptosis"},{"rate":"1-5","effect":"Facial asymmetry"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"NT 201 works by cleaving SNARE proteins required for acetylcholine vesicle fusion and release at motor nerve terminals. This results in temporary muscle relaxation and reduction of dynamic wrinkles and facial lines. The effect is reversible and typically lasts 3-4 months before neuromuscular function gradually recovers.","oneSentence":"NT 201 is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to temporarily paralyze muscles.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:53.777Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Temporary improvement of moderate to severe glabellar lines (frown lines between eyebrows)"},{"name":"Temporary improvement of forehead lines and crow's feet"}]},"trialDetails":[{"nctId":"NCT07489430","phase":"PHASE2","title":"DaxibotulinumtoxinA for Blepharospasm","status":"NOT_YET_RECRUITING","sponsor":"University of Pennsylvania","startDate":"2026-07-01","conditions":"Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid, Blepharospasm of Right Eyelid","enrollment":20},{"nctId":"NCT07486830","phase":"PHASE2","title":"IncobotulinumtoxinA for Provoked Vestibulodynia With Overactive Pelvic Floor Muscle Dysfunction","status":"RECRUITING","sponsor":"Center for Vulvovaginal Disorders","startDate":"2026-02-27","conditions":"Provoked Vestibulodynia","enrollment":54},{"nctId":"NCT07398755","phase":"","title":"Prospective, Non-interventional Study Assessing Periorbital Rejuvenation Procedure","status":"COMPLETED","sponsor":"Yuvell","startDate":"2025-09-02","conditions":"Glabellar Lines, Midface Volume Deficiency, Periorbital Wrinkling","enrollment":29},{"nctId":"NCT07018700","phase":"PHASE3","title":"A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine","status":"RECRUITING","sponsor":"Merz Therapeutics GmbH","startDate":"2025-08-21","conditions":"Episodic Migraine","enrollment":990},{"nctId":"NCT07018713","phase":"PHASE3","title":"A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine","status":"RECRUITING","sponsor":"Merz Therapeutics GmbH","startDate":"2025-08-21","conditions":"Chronic Migraine","enrollment":780},{"nctId":"NCT03992404","phase":"PHASE3","title":"Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury","status":"ACTIVE_NOT_RECRUITING","sponsor":"Merz Pharmaceuticals GmbH","startDate":"2019-09-16","conditions":"Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury","enrollment":603},{"nctId":"NCT03977493","phase":"PHASE3","title":"IncobotulinumtoxinA (Xeomin) to Treat Focal Hand Dystonia","status":"RECRUITING","sponsor":"Alain Kaelin","startDate":"2018-02-21","conditions":"Focal Hand Dystonia","enrollment":48},{"nctId":"NCT06782464","phase":"NA","title":"Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment","status":"RECRUITING","sponsor":"Centre National de Rééducation Fonctionnelle et de Réadaptation","startDate":"2024-12-12","conditions":"Hemiplegia, Spasticity, Shoulder Spasticity","enrollment":50},{"nctId":"NCT07426640","phase":"NA","title":"Dual-Site Botulinum Toxin Type A Injection for Lifelong Premature Ejaculation","status":"COMPLETED","sponsor":"Al Mouwasat Hospital","startDate":"2021-11-01","conditions":"Premature (Early) Ejaculation","enrollment":150},{"nctId":"NCT07473635","phase":"NA","title":"Perineural Incobotulinumtoxin-A for Complex Regional Pain Syndrome - An Open-label Feasibility Study","status":"RECRUITING","sponsor":"Bo Biering-Soerensen","startDate":"2026-01-07","conditions":"CRPS (Complex Regional Pain Syndromes), CRPS (Complex Regional Pain Syndrome) Type I, CRPS Type II","enrollment":20},{"nctId":"NCT07210463","phase":"PHASE3","title":"A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in Europe (PLATINUM EU)","status":"RECRUITING","sponsor":"Merz Aesthetics GmbH","startDate":"2025-10-01","conditions":"Neuromuscular Agents, Peripheral Nervous System Agents, Physiological Effects of Drugs","enrollment":300},{"nctId":"NCT07440173","phase":"PHASE4","title":"Phenol and Botulinum Toxin vs Botulinum Toxin Alone for Post-Stroke Upper-Limb Spasticity","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-05-01","conditions":"Spasticity as Sequela of Stroke","enrollment":60},{"nctId":"NCT07422428","phase":"","title":"Overlooked Barrier To Discontinuing Bont-A Therapy","status":"COMPLETED","sponsor":"Suleyman Demirel University","startDate":"2024-09-23","conditions":"Post Stroke Spastic Hemiplegia","enrollment":81},{"nctId":"NCT06995287","phase":"PHASE3","title":"Evaluation of the Analgesic Effect of Intramyometrial Botulinum Toxin Injection Via Hysteroscopy in Severe Primary Dysmenorrhea","status":"RECRUITING","sponsor":"Nantes University Hospital","startDate":"2026-02-09","conditions":"Primary Dysmenorrhea, Chronic Pelvic Pain","enrollment":222},{"nctId":"NCT07374965","phase":"","title":"A Prospective, Non-Interventional, Single-Centre Study Assessing the Efficacy of a Holistic Upper Face Treatment With Botulinum Neurotoxin A","status":"COMPLETED","sponsor":"Yuvell","startDate":"2024-01-29","conditions":"Glabellar Lines, Forehead Lines, Crow's Feet","enrollment":20},{"nctId":"NCT06070987","phase":"NA","title":"Exoskeleton Robotic Assisted Gait Training in Spastic Stroke Post Botulinum Toxin A Injection","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2023-08-01","conditions":"Spastic Gait, Spastic","enrollment":30},{"nctId":"NCT07303582","phase":"PHASE4","title":"Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities","status":"RECRUITING","sponsor":"Oxford University Hospitals NHS Trust","startDate":"2025-12-02","conditions":"Centreal Neurological Condition, Acquired Brain Injury (Including Stroke), Multiple Sclerosis","enrollment":50},{"nctId":"NCT02325063","phase":"NA","title":"Evaluation of Three Types of Injection for the Treatment of Lateral Epicondylalgia","status":"TERMINATED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2015-12-17","conditions":"Epicondylitis, Lateral Humeral, Tennis Elbow","enrollment":13},{"nctId":"NCT07266064","phase":"NA","title":"Repeated Botulinum Toxin Type A Injections on Intramuscular Fat Accumulation in Individuals With Sleep Bruxism.","status":"COMPLETED","sponsor":"Melek Volkan Yazici","startDate":"2024-01-02","conditions":"Bruxism, Bruxism, Sleep, Bruxism, Sleep-Related","enrollment":27},{"nctId":"NCT07267819","phase":"","title":"Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents","status":"RECRUITING","sponsor":"Uniformed Services University of the Health Sciences","startDate":"2025-08-05","conditions":"Migraine, Traumatic Brain Injury, Anomalous Health Incidents","enrollment":60},{"nctId":"NCT04908423","phase":"PHASE4","title":"Xeomin® and Gait Related Mobility After Stroke","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2021-10-19","conditions":"Stroke","enrollment":20},{"nctId":"NCT07122193","phase":"PHASE3","title":"A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in the United States","status":"RECRUITING","sponsor":"Merz North America, Inc.","startDate":"2025-08-27","conditions":"Neuromuscular Agents, Peripheral Nervous System Agents, Physiological Effects of Drugs","enrollment":300},{"nctId":"NCT06604832","phase":"PHASE1","title":"Effects of Microtox on Facial Skin Quality, Fine Wrinkles, and Texture","status":"COMPLETED","sponsor":"Kalpna Kay Durairaj, MD, FACS","startDate":"2024-09-03","conditions":"Skin Aging, Skin Wrinkling","enrollment":20},{"nctId":"NCT05169775","phase":"","title":"A Single Centre, Prospective, Observational Study to Assess the Use of the Rehabilitation Tool, GripAble, in Patients With Upper Limb Spasticity Receiving Botulinum Toxin-A (BoNT-A) in the United Kingdom (UK).","status":"COMPLETED","sponsor":"Ipsen","startDate":"2022-03-02","conditions":"Upper Limb Spasticity (ULS)","enrollment":16},{"nctId":"NCT06293300","phase":"PHASE2","title":"Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)","status":"RECRUITING","sponsor":"University of Miami","startDate":"2024-09-30","conditions":"Traumatic Brain Injury","enrollment":50},{"nctId":"NCT05224349","phase":"","title":"Effectiveness and Safety of SMART [Spastic Muscle Palpation by Anatomic Landscape for BoNT-A (Botulinumtoxin-A) Injection to Reduce Muscle Tone] BoNT-A Therapy With Dysport® in Patients With Post-stroke Chronic Upper Limb Spasticity (ULS) in Real-life Setting.","status":"COMPLETED","sponsor":"Ipsen","startDate":"2022-05-09","conditions":"Post-Stroke Chronic Upper Limb Spasticity","enrollment":121},{"nctId":"NCT03848143","phase":"PHASE2","title":"Intraoral Administration of Botox in Patients With Dentoalveolar Neuropathic Pain","status":"COMPLETED","sponsor":"Isabel Moreno Hay","startDate":"2019-09-11","conditions":"Neuropathic Pain","enrollment":10},{"nctId":"NCT06091020","phase":"PHASE2","title":"A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participants Aged 18 Years and Older With Chronic Nerve Pain After Shingles or Nerve Injury","status":"COMPLETED","sponsor":"Merz Therapeutics GmbH","startDate":"2023-11-22","conditions":"Moderate to Severe Chronic Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN) or Peripheral Nerve Injury","enrollment":123},{"nctId":"NCT07070817","phase":"NA","title":"A Clinical Study of Ultrasound-guided Botulinum Toxin A Into Salivary Gland for Sialorrhea After True Bulbar Palsy","status":"ENROLLING_BY_INVITATION","sponsor":"houyajing","startDate":"2024-06-01","conditions":"Sialorrhea True Bulbar Palsy Medullary Injury","enrollment":70},{"nctId":"NCT05874154","phase":"NA","title":"Evaluation of Tibial Nerve Selective Neurotomy Compared to Botulinum Toxin Injections for Spastic Foot Treatment in Post-stroke Patients According to a Goal-centered Approach","status":"RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2024-01-02","conditions":"Post Stroke Seizure, Spastic Foot","enrollment":60},{"nctId":"NCT05327972","phase":"PHASE2","title":"DEgenerative ROtator Cuff Disease and Botulinum TOXin","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2023-01-20","conditions":"Degenerative Rotator Cuff Disease","enrollment":60},{"nctId":"NCT07007858","phase":"NA","title":"Effects of High-Velocity Passive Stretch on Spasticity, Function, and Muscle Structure in Spastic CP Children","status":"ENROLLING_BY_INVITATION","sponsor":"TC Erciyes University","startDate":"2026-06-01","conditions":"Cerebral Palsy (CP), Spastic Diplegia Cerebral Palsy, Spastic Hemiplegic Cerebral Palsy","enrollment":34},{"nctId":"NCT03985982","phase":"PHASE3","title":"Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study III (BLESSIII)","status":"COMPLETED","sponsor":"Croma-Pharma GmbH","startDate":"2019-04-29","conditions":"Glabellar Frown Lines","enrollment":410},{"nctId":"NCT04075981","phase":"PHASE3","title":"Prevention Atrial Fibrillation by BOTulinum Toxin Injections (BOTAF)","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-09-30","conditions":"Cardiac Surgery","enrollment":220},{"nctId":"NCT05598723","phase":"PHASE3","title":"BOTOX® vs. XEOMIN® for Chronic Migraine","status":"RECRUITING","sponsor":"Naval Medical Center Camp Lejeune","startDate":"2023-02-24","conditions":"Chronic Migraine","enrollment":128},{"nctId":"NCT04965311","phase":"PHASE2","title":"Endoscopic Botulinum Toxin Injection in the Prevention of Postoperative Pancreatic Fistula Following Distal Pancreatectomy","status":"TERMINATED","sponsor":"OHSU Knight Cancer Institute","startDate":"2023-03-01","conditions":"Pancreatic Carcinoma","enrollment":4},{"nctId":"NCT06886750","phase":"PHASE4","title":"The Effects of Waning of Botulinum Toxin in the Treatment of Cervical Dystonia","status":"NOT_YET_RECRUITING","sponsor":"Western University, Canada","startDate":"2025-03-30","conditions":"Cervical Dystonia, Primary","enrollment":45},{"nctId":"NCT02677805","phase":"PHASE3","title":"Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study II","status":"COMPLETED","sponsor":"Croma-Pharma GmbH","startDate":"2016-03-30","conditions":"Glabellar Frown Lines","enrollment":251},{"nctId":"NCT02677298","phase":"PHASE3","title":"Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study I","status":"COMPLETED","sponsor":"Croma-Pharma GmbH","startDate":"2016-03-02","conditions":"Glabellar Frown Lines","enrollment":784},{"nctId":"NCT04763265","phase":"PHASE2","title":"Study to Compare 2 Botulinum Type A Toxins in the Treatment of Glabellar Frown Lines","status":"COMPLETED","sponsor":"Croma-Pharma GmbH","startDate":"2020-06-24","conditions":"Frown Lines","enrollment":208},{"nctId":"NCT04970407","phase":"PHASE1","title":"A Comparative Study to Evaluate the Effects and Mechanism of Action of Dysport®, Botox® and Xeomin® in the Extensor Digitorum Brevis Model in Healthy Adult Male Participants","status":"COMPLETED","sponsor":"Ipsen","startDate":"2021-07-06","conditions":"Healthy Participants","enrollment":45},{"nctId":"NCT06811142","phase":"EARLY_PHASE1","title":"Early Botulinum Toxin for Muscle Stiffness Reduction in First-Time Stroke Patients: Improving Recovery and Independence","status":"ACTIVE_NOT_RECRUITING","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2025-01-28","conditions":"Spasticity, Stroke, Neurological Rehabilitation","enrollment":200},{"nctId":"NCT02019004","phase":"EARLY_PHASE1","title":"A Pilot Study Testing Onabotulinum Toxin A Versus Incobotulinum Toxin A Injections for Facial Wrinkles","status":"ACTIVE_NOT_RECRUITING","sponsor":"Northwestern University","startDate":"2013-11","conditions":"Wrinkles","enrollment":20},{"nctId":"NCT06793683","phase":"EARLY_PHASE1","title":"Early BOTOX After Spinal Cord Injury","status":"ENROLLING_BY_INVITATION","sponsor":"University of Washington","startDate":"2024-07-27","conditions":"Spinal Cord Injuries","enrollment":10},{"nctId":"NCT06499324","phase":"PHASE3","title":"Surgery with Botulinum Toxin a for Incisional Hernia","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-01-17","conditions":"Incisional Hernia","enrollment":260},{"nctId":"NCT05167864","phase":"NA","title":"Evaluation of Four Injectable Neuromodulators in the Glabella Area Glabella Area","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2022-03-04","conditions":"Cosmetic Techniques","enrollment":143},{"nctId":"NCT06767631","phase":"NA","title":"Pilot Study on Muscle, Tendon, and Neural Changes Post-Botulinum Toxin Injections in Post-stroke Spastic Equinovarus","status":"NOT_YET_RECRUITING","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2025-05-02","conditions":"Stroke, Spasticity, Equinovarus Foot","enrollment":12},{"nctId":"NCT05196308","phase":"PHASE2","title":"Efficacy of Intracavernosal as add-on Therapy to Sildenafil 100 mg on Demand Compared to Sildenafil 100 mg on Demand for the Treatment of Erectile Dysfunction (ED) Not Sufficiently Responsive to Standard Therapy With Phosphodiesterase Type 5 Inhibitors","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2022-03-18","conditions":"Erectile Dysfunction","enrollment":226},{"nctId":"NCT06677216","phase":"","title":"Botulinum Toxin in the Management of Temporo-mandibular Related Myalgia: a Prospective Study","status":"ENROLLING_BY_INVITATION","sponsor":"Diakonessenhuis, Utrecht","startDate":"2024-01-26","conditions":"TMD/Orofacial Pain, Myalgia of Mastication Muscle, Botulinum Toxin, Type a","enrollment":30},{"nctId":"NCT05146999","phase":"PHASE3","title":"Assess Aesthetic Improvement and Onset of QM1114-DP in Subjects With Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2022-05-09","conditions":"Glabellar Frown Lines","enrollment":132},{"nctId":"NCT05773053","phase":"PHASE2","title":"A Study of NT 201 Doses in the Treatment of Platysma Prominence","status":"COMPLETED","sponsor":"Merz Aesthetics GmbH","startDate":"2023-03-22","conditions":"Platysma Prominence","enrollment":73},{"nctId":"NCT06205797","phase":"PHASE3","title":"To Evaluate HU-045 in the Treatment of Glabellar Lines(Phase III)","status":"RECRUITING","sponsor":"Huons Biopharma","startDate":"2024-06-20","conditions":"Glabellar Lines","enrollment":312},{"nctId":"NCT06448676","phase":"PHASE4","title":"Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides","status":"NOT_YET_RECRUITING","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2025-01-01","conditions":"Wrinkle","enrollment":200},{"nctId":"NCT06218316","phase":"NA","title":"Repetitive Transcranial Magnetic Stimulation Versus Botulinum Injection on Spasticity on Children With Diplegic Cerebral Palsy","status":"COMPLETED","sponsor":"MTI University","startDate":"2023-10-15","conditions":"Spastic Diplegic Cerebral Palsy","enrollment":75},{"nctId":"NCT06583551","phase":"NA","title":"Effectiveness of Botox, Dry Needling, Pharmacological Treatment, and Manual Therapy for Bruxism-Induced Myalgia","status":"COMPLETED","sponsor":"Saglik Bilimleri Universitesi","startDate":"2021-01-03","conditions":"Myalgia, Bruxism, Quality of Life","enrollment":80},{"nctId":"NCT06569342","phase":"","title":"Botulinum Neurotoxin Type A (BoNT-A) in Paediatric Non-neurogenic Therapy Resistant Overactive Bladder (OAB)","status":"COMPLETED","sponsor":"University of Aarhus","startDate":"2022-01-15","conditions":"Overactive Bladder, Incontinence, Daytime Urinary, Incontinence, Nighttime Urinary","enrollment":43},{"nctId":"NCT05784363","phase":"PHASE1","title":"A Study of NT 201 in the Treatment of Enlarged Pores and Excessive Sebum Production in the Face","status":"COMPLETED","sponsor":"Merz North America, Inc.","startDate":"2022-10-27","conditions":"Enlarged Pores, Sebum Production","enrollment":31},{"nctId":"NCT05884528","phase":"","title":"Assessment of Long-term Clinical Response to BoNT in Cervical Dystonia","status":"COMPLETED","sponsor":"Merz Therapeutics GmbH","startDate":"2023-07-08","conditions":"Cervical Dystonia","enrollment":270},{"nctId":"NCT04622254","phase":"PHASE3","title":"Safety and Efficacy Study of the Simultaneous Treatment of Upper Facial Lines (Horizontal Forehead Lines, Glabellar Frown Lines and Crows Feet) in Subjects With Moderate to Severe Upper Facial Lines","status":"COMPLETED","sponsor":"Merz North America, Inc.","startDate":"2020-11-12","conditions":"Moderate to Severe Upper Facial Lines (Horizontal Forehead Lines, Glabellar Frown Lines, and Lateral Canthal Lines)","enrollment":368},{"nctId":"NCT06203470","phase":"PHASE4","title":"Botox Versus Tacrolimus in Psoriasis Vulgaris","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-06","conditions":"Psoriasis Vulgaris","enrollment":60},{"nctId":"NCT04594213","phase":"PHASE3","title":"Safety and Efficacy Study of the Simultaneous Treatment of Upper Facial Lines (Horizontal Forehead Lines, Glabellar Frown Lines and Lateral Canthal Lines) in Subjects With Moderate to Severe Upper Facial Lines","status":"COMPLETED","sponsor":"Merz North America, Inc.","startDate":"2020-09-23","conditions":"Moderate to Severe Upper Facial Lines (Horizontal Forehead Lines, Glabellar Frown Lines, and Lateral Canthal Lines)","enrollment":362},{"nctId":"NCT06386848","phase":"","title":"Strategy to Adapt Botulinum Toxin Doses in Dystonia","status":"UNKNOWN","sponsor":"Central Hospital, Nancy, France","startDate":"2024-05-01","conditions":"Dystonia","enrollment":100},{"nctId":"NCT04766723","phase":"PHASE2","title":"A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm","status":"COMPLETED","sponsor":"Merz Pharmaceuticals GmbH","startDate":"2021-02-24","conditions":"Essential Tremor of the Upper Limb","enrollment":78},{"nctId":"NCT06345677","phase":"NA","title":"Clinical Trial for the Assessment of Safety, Usability and Efficacy of the Vixe Combination for OAB in Female Subjects","status":"COMPLETED","sponsor":"Vensica Therapeutics Ltd.","startDate":"2023-06-09","conditions":"Overactive Bladder","enrollment":48},{"nctId":"NCT06331533","phase":"PHASE4","title":"Intradermal BoNT-A Treatment in Erythematotelangiectatic Rosacea","status":"COMPLETED","sponsor":"Istanbul Training and Research Hospital","startDate":"2022-11-01","conditions":"Erythematotelangiectatic Rosacea","enrollment":30},{"nctId":"NCT05456087","phase":"PHASE2","title":"Use of Botulinum Toxin in the Treatment of Androgenic Alopecia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Zel Skin and Laser Specialists","startDate":"2022-08-12","conditions":"Androgenetic Alopecia","enrollment":20},{"nctId":"NCT05277337","phase":"PHASE4","title":"Study Comparing Treatment With Alluzience vs Reconstituted Toxin","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2022-02-04","conditions":"Glabellar Frown Lines","enrollment":150},{"nctId":"NCT06225024","phase":"NA","title":"Efficacy of Extracorporeal Shock Wave Therapy on Spasticity","status":"COMPLETED","sponsor":"Kayseri City Hospital","startDate":"2022-03-15","conditions":"Stroke, Spasticity, Muscle","enrollment":40},{"nctId":"NCT06250543","phase":"PHASE4","title":"Evaluation of Intradetrusor AbobotulinumtoxinA and IncobotulinumtoxinA in Women With Overactive Bladder","status":"COMPLETED","sponsor":"Niko Kavcic","startDate":"2018-08-14","conditions":"Overactive Bladder","enrollment":64},{"nctId":"NCT03543254","phase":"PHASE2","title":"\"Follow the Sutures\". A New Procedure for Injection of Botulinum Toxin for Chronic Migraine","status":"COMPLETED","sponsor":"Norwegian University of Science and Technology","startDate":"2018-05-01","conditions":"Migraine Disorders, Chronic Disease","enrollment":20},{"nctId":"NCT05980559","phase":"PHASE3","title":"Evaluation of BTX Injections in Treatment of Bruxism","status":"UNKNOWN","sponsor":"Alexandria University","startDate":"2024-01-15","conditions":"Bruxism","enrollment":12},{"nctId":"NCT06128616","phase":"PHASE3","title":"Efficacy of Extracorporeal Shock Wave Therapy in Children With Cerebral Palsy","status":"UNKNOWN","sponsor":"Kocaeli University","startDate":"2023-11","conditions":"Spasticity/Paresis, Cerebral Palsy","enrollment":40},{"nctId":"NCT03806933","phase":"PHASE2","title":"Study to Investigate the Safety and Duration of Effect of Different Botulinum Toxin A (NT 201) Dose Groups Following the Treatment of Glabellar Frown Lines","status":"COMPLETED","sponsor":"Merz Aesthetics GmbH","startDate":"2019-01-23","conditions":"Moderate to Severe Glabellar Frown Lines","enrollment":241},{"nctId":"NCT06034288","phase":"PHASE2","title":"Xeomin vs Botox for Treatment of Overactive Bladder Syndrome","status":"UNKNOWN","sponsor":"Walter Reed National Military Medical Center","startDate":"2023-05-04","conditions":"Overactive Bladder Syndrome","enrollment":64},{"nctId":"NCT06044883","phase":"PHASE1, PHASE2","title":"Radiological Evaluation of the Penis Before and After a Botox Injection","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-06-01","conditions":"Erectile Dysfunction","enrollment":32},{"nctId":"NCT03380559","phase":"PHASE3","title":"A Phase III Study to Evaluate Efficacy of Botulinum Toxin for Treating Epicondylitis","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-04-19","conditions":"Epicondylitis","enrollment":33},{"nctId":"NCT04826900","phase":"NA","title":"Wearable Robotic System and Robotic Mirror Therapy in Spastic Hemiplegia Post Botulinum Toxin Injection","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2019-08-01","conditions":"Hemiplegia, Spastic, Spastic","enrollment":31},{"nctId":"NCT06036043","phase":"","title":"Botulinum Toxin for Chronic Neuropathic Pain","status":"UNKNOWN","sponsor":"Region Zealand","startDate":"2023-08-01","conditions":"Neuralgia, Chronic Pain","enrollment":12},{"nctId":"NCT04247074","phase":"PHASE3","title":"Treatment of Moderate to Severe Lateral Canthal Lines and Glabellar Lines Alone or in Combination","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2020-02-10","conditions":"Glabellar Frown Lines (GL), Lateral Canthal Lines (LCL)","enrollment":413},{"nctId":"NCT04544280","phase":"NA","title":"Effect of Repeated Injections of Higher Doses of Botulinum Toxin on Lower Limb of Spastic Hemiplegic Patients on Gait.","status":"COMPLETED","sponsor":"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","startDate":"2018-09-13","conditions":"Stroke","enrollment":32},{"nctId":"NCT05298449","phase":"PHASE2","title":"Phase 2 of HU-045 in Glabellar Lines","status":"COMPLETED","sponsor":"Huons Co., Ltd.","startDate":"2022-03-28","conditions":"Glabellar Lines","enrollment":50},{"nctId":"NCT02088632","phase":"PHASE2","title":"Incobotulinum Toxin for the Treatment of Trigeminal Neuralgia","status":"TERMINATED","sponsor":"Thomas Jefferson University","startDate":"2014-03-14","conditions":"Trigeminal Neuralgia","enrollment":6},{"nctId":"NCT05585398","phase":"PHASE1","title":"A Study to Evaluate the Distribution of Botulinum Neurotoxin Type A Administered as Intradermal Injections, Comparing Different Doses, Concentrations, and Delivery Methods","status":"COMPLETED","sponsor":"Merz Pharmaceuticals GmbH","startDate":"2022-10-19","conditions":"N/A, as no Specific Medical Condition Will be Treated","enrollment":40},{"nctId":"NCT04249583","phase":"PHASE3","title":"Treatment of Moderate to Severe Glabellar Lines","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2020-02-10","conditions":"Glabellar Frown Lines","enrollment":300},{"nctId":"NCT04249687","phase":"PHASE3","title":"Treatment of Moderate to Severe Lateral Canthal Lines","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2020-02-10","conditions":"Lateral Canthal Lines","enrollment":303},{"nctId":"NCT05222607","phase":"","title":"Longitudinal Evaluation and Real-world Evidence of NT201","status":"TERMINATED","sponsor":"Merz North America, Inc.","startDate":"2023-02-10","conditions":"Glabellar Frown Lines and Canthal Lines and/or Horizontal Forehead Lines in the Upper Face","enrollment":11},{"nctId":"NCT02107261","phase":"PHASE2","title":"Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand","status":"COMPLETED","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2014-03","conditions":"Dystonia","enrollment":21},{"nctId":"NCT05309564","phase":"NA","title":"Muscle Weakness Duration After Single Botulinum Toxin Injection in Masseter","status":"COMPLETED","sponsor":"Region Västerbotten","startDate":"2020-03-01","conditions":"Bite Force, Botulinum Toxins, Type A","enrollment":32},{"nctId":"NCT05604729","phase":"NA","title":"The Effect on Envelope of Motion in Asymptomatic Bruxers","status":"UNKNOWN","sponsor":"Region Västerbotten","startDate":"2023-09-01","conditions":"Tooth Wear, Bruxism","enrollment":60},{"nctId":"NCT05617118","phase":"","title":"BTA vs Baclofen for Pelvic Myofascial Pain Syndrome","status":"UNKNOWN","sponsor":"Saint Petersburg State University, Russia","startDate":"2022-12-01","conditions":"Chronic Pain, Chronic Pelvic Pain Syndrome, Myofascial Pain Syndrome","enrollment":52},{"nctId":"NCT02965976","phase":"PHASE2","title":"Botulinum Toxin Type A in Preventing Complications After Surgery in Patients With Esophageal Cancer","status":"COMPLETED","sponsor":"Roswell Park Cancer Institute","startDate":"2016-12-30","conditions":"Esophageal Carcinoma","enrollment":33},{"nctId":"NCT05605886","phase":"EARLY_PHASE1","title":"Botulinum Toxin A in Patients With Myofascial Pain Syndrome With and Without Zinc Supplementation","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2022-05-20","conditions":"Myofacial Pain Syndrome, Botulinum Toxin","enrollment":24},{"nctId":"NCT05623410","phase":"PHASE3","title":"Study to Compare the Efficacy and Safety of ATGC-110 (Botulinum Toxin) With Xeomin® for the Treatment of Moderate to Severe Glabellar Frown Lines","status":"UNKNOWN","sponsor":"ATGC Co., Ltd.","startDate":"2022-10-11","conditions":"Glabellar Frown Lines","enrollment":300},{"nctId":"NCT01686061","phase":"","title":"Blepharospasm Patient Survey for Patients With Blepharospasm","status":"COMPLETED","sponsor":"Merz Pharmaceuticals GmbH","startDate":"2012-09","conditions":"Blepharospasm","enrollment":124},{"nctId":"NCT01486264","phase":"PHASE4","title":"Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With Cervical Dystonia Flex","status":"COMPLETED","sponsor":"Merz Pharmaceuticals GmbH","startDate":"2012-01-20","conditions":"Cervical Dystonia","enrollment":283},{"nctId":"NCT04810429","phase":"PHASE4","title":"Comparison of Temporomandibular Joint Arthroscopy With Botulinum Toxin Injection Versus Placebo","status":"COMPLETED","sponsor":"Instituto Portugues da Face","startDate":"2021-01-01","conditions":"Temporomandibular Joint Disorders","enrollment":15},{"nctId":"NCT04148872","phase":"PHASE4","title":"Mixed Methods Investigation of Chronic Facial Paralysis in Individuals With Synkinesis","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2019-10-24","conditions":"Synkinesis","enrollment":15},{"nctId":"NCT05536570","phase":"PHASE4","title":"Whiplash-induced Thoracic Outlet Syndrome Treated With Botulinum Toxin.","status":"UNKNOWN","sponsor":"King, David, MD","startDate":"2022-10-15","conditions":"Thoracic Outlet Syndrome, Whiplash Injuries","enrollment":15},{"nctId":"NCT05531968","phase":"PHASE3","title":"Treatment of Moderate to Severe Glabellar Lines (BMI2006)","status":"COMPLETED","sponsor":"BMI Korea","startDate":"2021-02-09","conditions":"Glabellar Lines","enrollment":278},{"nctId":"NCT05517538","phase":"NA","title":"Split-face Study: Cosmetic Botulinum Toxin Type A Injection Under Electromyography-guidance Versus Conventional Palpation Technique","status":"COMPLETED","sponsor":"Mohamed Hayder Oleish Salih","startDate":"2021-08-09","conditions":"Glabellar Frown Lines, Rhytides, Wrinkle","enrollment":15}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"AORTIC ARTERIOSCLEROSIS"},{"count":1,"reaction":"CEREBRAL ARTERIOSCLEROSIS"},{"count":1,"reaction":"CEREBRAL ATROPHY"},{"count":1,"reaction":"CONDITION AGGRAVATED"},{"count":1,"reaction":"DISEASE RECURRENCE"},{"count":1,"reaction":"ENCEPHALOPATHY"},{"count":1,"reaction":"ISCHAEMIC STROKE"},{"count":1,"reaction":"LACUNAR INFARCTION"},{"count":1,"reaction":"MUCOUS MEMBRANE DISORDER"},{"count":1,"reaction":"MUSCULAR WEAKNESS"}],"_approvalHistory":[],"publicationCount":39,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["IncobotulinumtoxinA","Xeomin/Bocouture","Xeomin Cosmetic","Xeomeen","Incobotulinumtoxin A"],"phase":"marketed","status":"active","brandName":"NT 201","genericName":"NT 201","companyName":"Merz Aesthetics GmbH","companyId":"merz-aesthetics-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NT 201 is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to temporarily paralyze muscles. Used for Temporary improvement of moderate to severe glabellar lines (frown lines) in adults, Temporary improvement of moderate to severe lateral canthal lines (crow's feet) in adults, Temporary improvement of moderate to severe forehead lines in adults.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":5,"withResults":4},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}