{"id":"nph-reg","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypoglycemia"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Lipodystrophy"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"NPH (Neutral Protamine Hagedorn) is an intermediate-acting insulin that peaks 4-8 hours after injection and provides basal coverage. Regular insulin is a short-acting insulin that works rapidly to lower postprandial glucose. The combination allows for both mealtime glucose control and sustained background insulin activity.","oneSentence":"NPH/Reg is a combination insulin therapy that provides both intermediate-acting (NPH) and rapid-acting (Regular) insulin to control blood glucose levels.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:57:51.782Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 1 diabetes mellitus"},{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT01889095","phase":"PHASE4","title":"Biphasic Insulin Aspart Versus NPH Plus Regular Human Insulin in Type 2 Diabetic Patients","status":"COMPLETED","sponsor":"Tehran University of Medical Sciences","startDate":"2011-07","conditions":"Diabetes Type 2","enrollment":160}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"NPH/Reg","genericName":"NPH/Reg","companyName":"Tehran University of Medical Sciences","companyId":"tehran-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NPH/Reg is a combination insulin therapy that provides both intermediate-acting (NPH) and rapid-acting (Regular) insulin to control blood glucose levels. Used for Type 1 diabetes mellitus, Type 2 diabetes mellitus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}