{"id":"nph-and-regular-insulin","safety":{"commonSideEffects":[{"rate":"variable, dose-dependent","effect":"Hypoglycemia"},{"rate":"common","effect":"Weight gain"},{"rate":"5-10","effect":"Injection site reactions"},{"rate":"rare to uncommon","effect":"Lipodystrophy"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Regular insulin is a short-acting insulin that begins working within 30 minutes and peaks in 2-4 hours, providing rapid glucose control after meals. NPH (Neutral Protamine Hagedorn) is an intermediate-acting insulin that begins working within 1-2 hours and peaks in 4-12 hours, providing basal glucose control throughout the day. The combination provides both mealtime and background insulin coverage.","oneSentence":"NPH and regular insulin work together to replace or supplement the body's natural insulin, allowing cells to take up glucose and lowering blood sugar levels.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:50.790Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 1 diabetes mellitus"},{"name":"Type 2 diabetes mellitus (when other agents are insufficient)"}]},"trialDetails":[{"nctId":"NCT02556840","phase":"NA","title":"Impact on Birth Weight of Two Therapeutic Strategies (Insulin Therapy From the Beginning of Pregnancy vs. Insulin Therapy Initiated According to Fetal Growth Evaluated by Ultrasonography Measurements) in Pregnant Women With Monogenic Diabetes","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2016-04-25","conditions":"Maturity-Onset Diabetes of the 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