{"id":"np101-sumatriptan-iontophoretic-transdermal-patch","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site reactions (erythema, pruritus)"},{"rate":null,"effect":"Chest pain or pressure"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Paresthesia"},{"rate":null,"effect":"Flushing"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Sumatriptan is a selective serotonin 5-HT1B/1D receptor agonist that constricts cranial blood vessels and inhibits neuropeptide release to relieve migraine headaches. The iontophoretic transdermal patch technology uses a small electrical current to actively transport the drug across the skin barrier, enabling faster onset of action compared to oral formulations while avoiding gastrointestinal absorption variability.","oneSentence":"NP101 delivers sumatriptan through the skin via iontophoresis, a technique using electrical current to enhance transdermal penetration, allowing rapid absorption without needles or oral administration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:23:28.178Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute migraine with or without aura"}]},"trialDetails":[{"nctId":"NCT01381796","phase":"PHASE1","title":"Compare PK and Bioavailability of 2 NP101 Patches With Oral Imitrex in Healthy Adults","status":"COMPLETED","sponsor":"NuPathe Inc.","startDate":"2009-12","conditions":"Compare Bioequivalence Patches Previously Used in the NP101-007 Study","enrollment":63},{"nctId":"NCT00806546","phase":"PHASE3","title":"An Open-Label Study to Evaluate the Safety of NP101 in the Treatment of Acute Migraine Over Twelve Months","status":"COMPLETED","sponsor":"NuPathe Inc.","startDate":"2009-02","conditions":"Migraine Disorders","enrollment":514},{"nctId":"NCT00792103","phase":"PHASE3","title":"An Open-Label Study to Evaluate the Safety of NP101 in the Treatment of Acute Migraine Over 12 Months","status":"COMPLETED","sponsor":"NuPathe Inc.","startDate":"2009-01","conditions":"Migraine Disorders","enrollment":198},{"nctId":"NCT00724815","phase":"PHASE3","title":"The Efficacy and Tolerability of NP101 Patch in the Treatment of Acute Migraine","status":"COMPLETED","sponsor":"NuPathe Inc.","startDate":"2009-01","conditions":"Migraine Disorders","enrollment":530},{"nctId":"NCT00720018","phase":"PHASE1","title":"Phase I Open Label Single-Dose Study to Compare the Pharmacokinetics of NP101 Healthy Volunteers","status":"COMPLETED","sponsor":"NuPathe Inc.","startDate":"2008-06","conditions":"Migraine Disorders","enrollment":4},{"nctId":"NCT00546650","phase":"PHASE1","title":"Phase I Study to Compare NP101(Sumatriptan Iontophoretic Transdermal Patch) With Three Formulations of Imitrex®","status":"COMPLETED","sponsor":"NuPathe Inc.","startDate":"2007-11","conditions":"Healthy","enrollment":25},{"nctId":"NCT00723983","phase":"PHASE1","title":"Phase I, Open Label, Single-Dose, Four Way Crossover Study to Compare the PK of NP101 With Oral Imitrex® (50mg) in Migraine Subjects During an Acute Migraine Attack and During a Non-Migraine Period","status":"COMPLETED","sponsor":"NuPathe Inc.","startDate":"2008-11","conditions":"Migraine Disorders","enrollment":23}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sumatriptan"],"phase":"phase_3","status":"active","brandName":"NP101 - Sumatriptan iontophoretic transdermal patch","genericName":"NP101 - Sumatriptan iontophoretic transdermal patch","companyName":"NuPathe Inc.","companyId":"nupathe-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NP101 delivers sumatriptan through the skin via iontophoresis, a technique using electrical current to enhance transdermal penetration, allowing rapid absorption without needles or oral administration. Used for Acute migraine with or without aura.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}