{"id":"novosis-bongros-bmp-2","safety":{"commonSideEffects":[{"rate":null,"effect":"Swelling and inflammation at application site"},{"rate":null,"effect":"Osteoclast activation and bone resorption"},{"rate":null,"effect":"Ectopic bone formation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"BMP-2 is a growth factor that belongs to the transforming growth factor-beta (TGF-β) superfamily and acts as a potent osteoinductive agent. It binds to serine/threonine kinase receptors on osteoprogenitor cells, triggering intracellular signaling cascades that promote differentiation into mature osteoblasts and subsequent bone matrix deposition. This mechanism makes it effective for enhancing bone regeneration in surgical and trauma settings.","oneSentence":"Novosis is a recombinant human bone morphogenetic protein-2 (BMP-2) that promotes bone formation by stimulating osteoblast differentiation and new bone growth.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:23:28.192Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bone regeneration and fracture healing in orthopedic surgery"},{"name":"Spinal fusion procedures"}]},"trialDetails":[{"nctId":"NCT01764906","phase":"NA","title":"The Clinical Study of Novosis in Posterolateral Fusion","status":"UNKNOWN","sponsor":"BioAlpha Inc.","startDate":"2013-03","conditions":"Posterolateral Fusion","enrollment":90},{"nctId":"NCT01634308","phase":"PHASE3","title":"Efficacy and Safety of Bongros-BMP Compared to Bio-oss for Regeneration of Alveolar Bone Tissue After Maxillary Sinus Floor Augmentation","status":"COMPLETED","sponsor":"Daewoong Pharmaceutical Co. LTD.","startDate":"2010-06","conditions":"Regeneration of Alveolar Tissue After Maxillary Sinus Floor Augmentation","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Novosis(bongros/BMP-2)","genericName":"Novosis(bongros/BMP-2)","companyName":"Daewoong Pharmaceutical Co. LTD.","companyId":"daewoong-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Novosis is a recombinant human bone morphogenetic protein-2 (BMP-2) that promotes bone formation by stimulating osteoblast differentiation and new bone growth. Used for Bone regeneration and fracture healing in orthopedic surgery, Spinal fusion procedures.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}