{"id":"novocart-3d-plus","safety":{"commonSideEffects":[{"rate":null,"effect":"Graft failure or poor integration"},{"rate":null,"effect":"Joint swelling"},{"rate":null,"effect":"Pain at implant site"},{"rate":null,"effect":"Infection"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The product involves harvesting cartilage cells from the patient, expanding them in vitro, and implanting them back into the cartilage defect within a 3D collagen-based scaffold. This approach aims to restore functional cartilage tissue and reduce pain and dysfunction in osteoarthritis or cartilage injury. The 3D scaffold provides structural support and guides tissue regeneration.","oneSentence":"NOVOCART® 3D plus is an autologous chondrocyte implant that regenerates cartilage tissue by delivering the patient's own expanded cartilage cells into a defect site.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:23:27.166Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Symptomatic cartilage defects of the knee"},{"name":"Osteoarthritis of the knee"}]},"trialDetails":[{"nctId":"NCT04186208","phase":"","title":"Non-interventional Study With NOVOCART® 3D for the Treatment of Cartilage Defects of the Knee in Pediatric Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Tetec AG","startDate":"2017-04-25","conditions":"Cartilage Disease","enrollment":42},{"nctId":"NCT01656902","phase":"PHASE3","title":"Phase III Study to Evaluate Safety and Effectiveness of NOVOCART 3D Plus vs. Microfracture in Knee Cartilage Defects","status":"COMPLETED","sponsor":"Tetec AG","startDate":"2013-05","conditions":"Traumatic Articular Cartilage Defects in the Knee Joint","enrollment":263}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Matrix-associated autologous chondrocyte implantation"],"phase":"phase_3","status":"active","brandName":"NOVOCART® 3D plus","genericName":"NOVOCART® 3D plus","companyName":"Tetec AG","companyId":"tetec-ag","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NOVOCART® 3D plus is an autologous chondrocyte implant that regenerates cartilage tissue by delivering the patient's own expanded cartilage cells into a defect site. Used for Symptomatic cartilage defects of the knee, Osteoarthritis of the knee.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}