{"id":"novocart-3d","safety":{"commonSideEffects":[{"rate":null,"effect":"Graft failure or poor integration"},{"rate":null,"effect":"Joint swelling"},{"rate":null,"effect":"Pain at implant site"},{"rate":null,"effect":"Infection"}]},"_chembl":{"chemblId":"CHEMBL3686109","moleculeType":"Small molecule","molecularWeight":"415.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The product uses a patient's own chondrocytes (cartilage cells) expanded ex vivo and seeded onto a 3D collagen-based scaffold to create a tissue-engineered cartilage graft. This construct is implanted into cartilage defects to restore joint surface integrity and function. The approach aims to promote natural cartilage regeneration and repair rather than symptomatic treatment.","oneSentence":"NOVOCART 3D is an autologous engineered cartilage construct that regenerates damaged articular cartilage by combining patient's own cells with a 3D scaffold.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:33.231Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Articular cartilage defects of the knee"}]},"trialDetails":[{"nctId":"NCT04186208","phase":"","title":"Non-interventional Study With NOVOCART® 3D for the Treatment of Cartilage Defects of the Knee in Pediatric Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Tetec AG","startDate":"2017-04-25","conditions":"Cartilage Disease","enrollment":42},{"nctId":"NCT03219307","phase":"PHASE3","title":"NOVOCART 3D Treatment Following Microfracture Failure","status":"ACTIVE_NOT_RECRUITING","sponsor":"Aesculap Biologics, LLC","startDate":"2018-11-30","conditions":"Articular Cartilage Defect","enrollment":30},{"nctId":"NCT01957722","phase":"PHASE3","title":"NOVOCART®3D for Treatment of Articular Cartilage of the Knee","status":"ACTIVE_NOT_RECRUITING","sponsor":"Aesculap Biologics, LLC","startDate":"2013-12","conditions":"Articular Cartilage of the Femoral Condyle Between 2-6cm2","enrollment":233},{"nctId":"NCT01656902","phase":"PHASE3","title":"Phase III Study to Evaluate Safety and Effectiveness of NOVOCART 3D Plus vs. Microfracture in Knee Cartilage Defects","status":"COMPLETED","sponsor":"Tetec AG","startDate":"2013-05","conditions":"Traumatic Articular Cartilage Defects in the Knee Joint","enrollment":263},{"nctId":"NCT02348697","phase":"","title":"Non-Interventional Study to Evaluate Safety and Efficacy of NOVOCART 3D in Patients With Cartilage Defects","status":"COMPLETED","sponsor":"Tetec AG","startDate":"2015-06","conditions":"Cartilage Diseases","enrollment":81}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":17,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"NOVOCART 3D","genericName":"NOVOCART 3D","companyName":"Aesculap Biologics, LLC","companyId":"aesculap-biologics-llc","modality":"Biologic","firstApprovalDate":"","aiSummary":"NOVOCART 3D is a small molecule used to treat cartilage diseases, including traumatic articular cartilage defects in the knee joint. It has been studied in clinical trials, including a Phase III study comparing its effectiveness to microfracture in treating knee cartilage defects.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}