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The 'novel' formulation likely refers to an improved delivery system, dosing regimen, or safety profile compared to conventional ibuprofen.","oneSentence":"Novel Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and decrease inflammation, pain, and fever.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:23:22.738Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain and inflammation (acute or chronic)"},{"name":"Fever reduction"}]},"trialDetails":[{"nctId":"NCT07498556","phase":"NA","title":"Immediate Restoration of a New Implant With High Primary Stability","status":"NOT_YET_RECRUITING","sponsor":"Universidade do Porto","startDate":"2026-03-01","conditions":"Dental Implants, Immediate Dental Implant Loading","enrollment":50},{"nctId":"NCT07393503","phase":"PHASE4","title":"Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New Injuries","status":"ENROLLING_BY_INVITATION","sponsor":"State 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