{"id":"novel-dose-adjustment-of-alutard-sq","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (erythema, swelling, pruritus)"},{"rate":null,"effect":"Systemic allergic reactions"},{"rate":null,"effect":"Anaphylaxis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alutard SQ works by administering increasing doses of allergen extract to induce immune tolerance and reduce allergic responses. The novel dose adjustment refers to an optimized dosing schedule that improves efficacy and safety compared to standard protocols. This approach modulates T-cell and B-cell responses to allergens, reducing IgE-mediated reactions and promoting regulatory T-cell development.","oneSentence":"Alutard SQ is an allergen immunotherapy product that desensitizes patients to specific allergens through gradual dose escalation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:35:09.678Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Allergic asthma"},{"name":"Atopic dermatitis"}]},"trialDetails":[{"nctId":"NCT04929093","phase":"PHASE4","title":"Novel Dose Adjustment Schedule for Late Injection in SCIT in AR","status":"COMPLETED","sponsor":"Beijing Tongren Hospital","startDate":"2020-06-11","conditions":"Allergic Rhinitis, Immunotherapy","enrollment":102}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Novel dose adjustment of Alutard SQ","genericName":"Novel dose adjustment of Alutard SQ","companyName":"Beijing Tongren Hospital","companyId":"beijing-tongren-hospital","modality":"Biologic","firstApprovalDate":"","aiSummary":"Alutard SQ is an allergen immunotherapy product that desensitizes patients to specific allergens through gradual dose escalation. Used for Allergic rhinitis and asthma caused by specific allergens (e.g., pollen, dust mites, animal dander).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}