{"id":"novarel","rwe":[],"tags":[],"phase":"discontinued","safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[],"contraindications":[],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"status":"discontinued","trials":["NCT04643925","NCT00954265","NCT02607293","NCT00953628","NCT01009723","NCT03105323","NCT01687712","NCT00883766","NCT05112692","NCT02022228","NCT01071200","NCT02979886","NCT06396390","NCT05123040","NCT04606082","NCT02437032","NCT03463772","NCT06356740","NCT02429999","NCT03495609","NCT02850692","NCT02381821","NCT03398993","NCT03445910","NCT04224818","NCT03484611","NCT03071172","NCT04870502","NCT01422733","NCT01100333","NCT02349945","NCT00166790","NCT05473273","NCT01984320","NCT01100346","NCT03254641","NCT00839319","NCT04992468","NCT02197208","NCT06486415","NCT02355925","NCT00663416","NCT04446845","NCT04852029","NCT05370794","NCT03785574","NCT06418347","NCT00697255","NCT01112358","NCT00223860"],"aliases":[],"patents":[],"pricing":[],"offLabel":[],"timeline":[],"aiSummary":"","brandName":"Novarel","companyId":"ferring-pharmaceuticals","ecosystem":[],"mechanism":{"target":"","novelty":"","modality":"Small molecule","drugClass":"","explanation":"","oneSentence":"","technicalDetail":""},"commercial":null,"references":[],"biosimilars":[],"companyName":"Ferring Pharmaceuticals","competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"}],"genericName":"Novarel","indications":{"approved":[],"offLabel":[],"pipeline":[]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT04643925","phase":"Phase 4","title":"Eight Weeks of Androgen Priming by hCG Before IVF/ICSI in Women With Low Ovarian Reserve","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","isPivotal":false,"enrollment":20,"indication":"Infertility, Female, Ovarian Reserve","completionDate":"2021-08-31"},{"nctId":"NCT00954265","phase":"Phase 3","title":"Phase III Study on the Effects of Recombinant HCG Ovulation Triggering on Stimulation, Embryonic and Pregnancy Parameters in an IVF Program","status":"UNKNOWN","sponsor":"Universitair Ziekenhuis Brussel","isPivotal":true,"enrollment":130,"indication":"Embryonic Development, Pregnancy","completionDate":"2010-09"},{"nctId":"NCT02607293","phase":"N/A","title":"An Exploratory Study to Explore the Correlation Between the Symptoms and Signs of Polycystic Ovarian Syndrome (PCOS) and Risk of Over-response Using New Gonal-f® Pen in Assisted Reproductive Technolog","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","isPivotal":false,"enrollment":1064,"indication":"Polycystic Ovary Syndrome","completionDate":"2017-06-28"},{"nctId":"NCT00953628","phase":"Phase 4","title":"Endometrial Advancement After Rec or u-HCG Triggering","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","isPivotal":false,"enrollment":130,"indication":"Infertility","completionDate":"2008-12"},{"nctId":"NCT01009723","phase":"N/A","title":"Early Prediction Of Preterm Delivery By Measurement Of Maternal Serum Markers","status":"UNKNOWN","sponsor":"Esoterix Genetic Laboratories, LLC","isPivotal":false,"enrollment":2000,"indication":"Preterm Delivery","completionDate":"2012-07"},{"nctId":"NCT03105323","phase":"N/A","title":"Role of Ratio of Progesterone to Number of Follicles as a Prognostic Tool for IntracytoplasmicSperm Injection Outcome","status":"UNKNOWN","sponsor":"Ain Shams Maternity Hospital","isPivotal":false,"enrollment":40,"indication":"Infertility, Female","completionDate":"2018-03-31"},{"nctId":"NCT01687712","phase":"Phase 3","title":"Phase III Investigator and Assessor Blinded 1:1 Randomized, Parallel-group Multicenter Study to Compare Efficacy and Safety of Two r-hFSH Formulations (AFOLIA vs Gonal-f® RFF) in Normal Ovulatory Wome","status":"COMPLETED","sponsor":"Fertility Biotech AG","isPivotal":true,"enrollment":1100,"indication":"Infertility","completionDate":"2016-11-14"},{"nctId":"NCT00883766","phase":"NA","title":"PCOS and IVF: A Comparison Between Standard Long Protocol Versus an Antagonist Protocol Starting on Day 1","status":"TERMINATED","sponsor":"Fundacion Dexeus","isPivotal":false,"enrollment":172,"indication":"Polycystic Ovary Syndrome, In Vitro Fertilization","completionDate":"2012-06"},{"nctId":"NCT05112692","phase":"NA","title":"Progestin-primed Ovarian Stimulation Protocol Versus GnRH Antagonist Protocol in Polycystic Ovary Syndrome Patients Undergoing IVF/ICSI Cycles","status":"UNKNOWN","sponsor":"Mansoura University","isPivotal":false,"enrollment":200,"indication":"PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries","completionDate":"2023-12"},{"nctId":"NCT02022228","phase":"NA","title":"Dual Trigger With GnRH Agonist and Human Chorionic Gonadotropin for Final Oocyte Maturation in Patients at High Risk of Ovarian Hyperstimulation Syndrome in GnRH Antagonist Protocol","status":"UNKNOWN","sponsor":"Chenshiling","isPivotal":false,"enrollment":200,"indication":"Infertility and at High Risk of OHSS","completionDate":"2016-06"},{"nctId":"NCT01071200","phase":"Phase 3","title":"A Phase III, Multicentric, Randomized, Open, Comparative Study to Evaluate if the Addition of Recombinant Human Luteinising Hormone [r-hLH (Luveris®)] to Follicle Stimulating Hormone (FSH) From Day 8 ","status":"TERMINATED","sponsor":"Merck KGaA, Darmstadt, Germany","isPivotal":true,"enrollment":133,"indication":"Reproductive Techniques, Assisted","completionDate":"2009-04"},{"nctId":"NCT02979886","phase":"NA","title":"Effects of Single Nucleotide Polymorphism of GnRH Receptor Genes on Clinical Response to Pituitary Down Regulation in IVF Patients","status":"UNKNOWN","sponsor":"Miao benyu","isPivotal":false,"enrollment":1500,"indication":"Infertility, Female","completionDate":"2019-12"},{"nctId":"NCT06396390","phase":"Phase 4","title":"The Comparative Results of Progestin Primed Ovarian Stimulation (PPOS) and GnRH Antagonist Ovarian Stimulation Methods on IVF Outcomes","status":"NOT_YET_RECRUITING","sponsor":"Nesta Clinic","isPivotal":false,"enrollment":152,"indication":"IVF, Fertility Issues","completionDate":"2026-08-01"},{"nctId":"NCT05123040","phase":"Phase 1","title":"Ruxolitinib, Human Chorionic Gonadotropin (uhCG/EGF), and Dose De-escalated Corticosteroids for Treatment of Minnesota High-Risk Acute GVHD (aGVHD): A Phase I/II Study","status":"TERMINATED","sponsor":"Masonic Cancer Center, University of Minnesota","isPivotal":false,"enrollment":10,"indication":"Acute-graft-versus-host Disease","completionDate":"2026-02-27"},{"nctId":"NCT04606082","phase":"NA","title":"Intra Uterine Injection of Human Chorionic Gonadotropin Versus Granulocyte Colony Stimulating Factor at Ovum Pick up Day Significantly Increase Implantation Rate and Pregnancy Rate in Intra Cytoplasmi","status":"UNKNOWN","sponsor":"Al-Azhar University","isPivotal":false,"enrollment":200,"indication":"Fertility Disorders","completionDate":"2021-01-10"},{"nctId":"NCT02437032","phase":"Phase 4","title":"Type of Gonadotropin During Controlled Ovarian Stimulation Affects the Endocrine Profile in Follicular Fluid and Apoptotic Rate in Granulose Cells","status":"COMPLETED","sponsor":"IVI Madrid","isPivotal":false,"enrollment":100,"indication":"Infertility","completionDate":"2012-12"},{"nctId":"NCT03463772","phase":"NA","title":"In Vitro Maturation Versus Standard in Vitro Fertilization in Infertile Patients Diagnosed With Polycystic Ovaries Syndrome: a Study Protocol for a Single-center Prospective, Randomized Controlled Cli","status":"UNKNOWN","sponsor":"Jie Qiao","isPivotal":false,"enrollment":350,"indication":"PCOS","completionDate":"2020-10"},{"nctId":"NCT06356740","phase":"Phase 2","title":"Randomized Pilot Trial to Evaluate the Efficacy and Tolerance of Abacavir/Lamivudine Treatment in Patients With Systemic Lupus Erythematosus (PENCIL)","status":"NOT_YET_RECRUITING","sponsor":"Hospices Civils de Lyon","isPivotal":false,"enrollment":70,"indication":"Systemic Lupus Erythematosus","completionDate":"2029-06-01"},{"nctId":"NCT02429999","phase":"Phase 2","title":"The Role of Aromatase Inhibitor (Letrozole) in Minimal Ovarian Stimulation Protocols in Assisted Reproductive Technology. A Randomized Controlled Trial","status":"UNKNOWN","sponsor":"Assiut University","isPivotal":false,"enrollment":80,"indication":"to Evaluate Letrozole as a Modality for Minimal Ovarian Stimulation in ICSI Cycles .","completionDate":"2017-12"},{"nctId":"NCT03495609","phase":"Phase 4","title":"The Use of Recombinant hCG to Prevent Breast Cancer in BRCA1 and BRCA2 Carriers","status":"COMPLETED","sponsor":"University Hospital, Ghent","isPivotal":false,"enrollment":33,"indication":"hCG, BRCA1 Mutation","completionDate":"2018-12-18"},{"nctId":"NCT02850692","phase":"NA","title":"Portal Hypertension and Systemic Endothelial Function: Investigation of Systemic Endothelial Dysfunction in Case of Portal Hypertension Associated With Cystic Fibrosis.","status":"UNKNOWN","sponsor":"Hopital Foch","isPivotal":false,"enrollment":60,"indication":"Cystic Fibrosis, Portal Hypertension","completionDate":"2021-12"},{"nctId":"NCT02381821","phase":"N/A","title":"The Measurement of Endometrial Volume and Sub-endometrial Vascularity to Replace the Traditional Endometrial Thickness as Predictors of In-vitro Fertilization Success","status":"COMPLETED","sponsor":"Cairo University","isPivotal":false,"enrollment":82,"indication":"Reproductive Techniques, Assisted","completionDate":"2017-12-31"},{"nctId":"NCT03398993","phase":"NA","title":"Comparative Study of Pregnancy Rate After Endometrial Injury in Couples With Unexplained Infertility","status":"UNKNOWN","sponsor":"Cairo University","isPivotal":false,"enrollment":100,"indication":"Unexplained Infertility","completionDate":"2018-12"},{"nctId":"NCT03445910","phase":"NA","title":"Effect of Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer on Implantation and Pregnancy Rates in Intracytoplasmic Sperm Injection: a Prospective Randomized Study","status":"COMPLETED","sponsor":"Ain Shams University","isPivotal":false,"enrollment":100,"indication":"Repeated Implantation Failure","completionDate":"2018-07-30"},{"nctId":"NCT04224818","phase":"Phase 3","title":"Dual Trigger in the Final Oocyte Maturation in Poor Ovarian Responders: A Prospective Randomized Controlled Trial","status":"COMPLETED","sponsor":"American University of Beirut Medical Center","isPivotal":true,"enrollment":140,"indication":"Poor Ovarian Reserve","completionDate":"2019-08-30"},{"nctId":"NCT03484611","phase":"NA","title":"Prediction of Metaphase II Oocytes According to Different Levels of Serum AMH in Poor Responders Using the Antagonist Protocol","status":"UNKNOWN","sponsor":"Cairo University","isPivotal":false,"enrollment":179,"indication":"Invitro Fertilizaion","completionDate":"2018-04"},{"nctId":"NCT03071172","phase":"Phase 3","title":"Clinical Study of Recombinant Human Follitropin for Injection Assisted in Controlled Ovarian Hyperstimulation Assisted IVF-ET","status":"UNKNOWN","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","isPivotal":true,"enrollment":252,"indication":"Ovarian Hyperstimulation Syndrome","completionDate":"2018-05"},{"nctId":"NCT04870502","phase":"Phase 2","title":"Effect of Ubiquinol Supplementation on Ovulation Induction in Clomiphene Citrate Resistance","status":"COMPLETED","sponsor":"Saudi German Hospital - Madinah","isPivotal":true,"enrollment":161,"indication":"Polycystic Ovarian Syndrome","completionDate":"2020-07-31"},{"nctId":"NCT01422733","phase":"EARLY/Phase 1","title":"Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen Overproduction in Overweight Early Pubertal Girls With Androgen Excess (CBS0004)","status":"WITHDRAWN","sponsor":"University of Virginia","isPivotal":false,"enrollment":0,"indication":"Hyperandrogenemia, Obesity","completionDate":"2018-07-17"},{"nctId":"NCT01100333","phase":"N/A","title":"Observational Study GONAL-f® Consort","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","isPivotal":false,"enrollment":2552,"indication":"Infertility","completionDate":"2011-07"},{"nctId":"NCT02349945","phase":"Phase 2","title":"Significance of the FSH Receptor Polymorphism p.N680S for the Efficacy of FSH Therapy of Idiopathic Male Infertility: a Pharmacogenetic Approach","status":"COMPLETED","sponsor":"Azienda USL Modena","isPivotal":true,"enrollment":88,"indication":"Male Infertility","completionDate":"2015-12"},{"nctId":"NCT00166790","phase":"N/A","title":"Detection of Minimal Amount of Human Chorionic Gonadotropin by Interferometry in Gestational Trophoblastic Disease","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","isPivotal":false,"enrollment":30,"indication":"Trophoblastic Neoplasms","completionDate":"2014-12"},{"nctId":"NCT05473273","phase":"N/A","title":"Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle (NC).","status":"RECRUITING","sponsor":"ART Fertility Clinics LLC","isPivotal":false,"enrollment":40,"indication":"Infertility, Female","completionDate":"2025-12-30"},{"nctId":"NCT01984320","phase":"NA","title":"Combining Cabergoline and Coasting in Gonadotropin Releasing Hormone(GnRH)Agonist Protocol in Intracytoplasmic Sperm Injection (ICSI) to Prevent Ovarian Hyperstimulation Syndrome (OHSS): a Randomized ","status":"COMPLETED","sponsor":"Cairo University","isPivotal":false,"enrollment":300,"indication":"OHSS","completionDate":"2015-07"},{"nctId":"NCT01100346","phase":"N/A","title":"A Prospective, Single Center, Observational Study on the Predictive Factors of Ovarian Response in Ovulation Induction (OI) With Intrauterine Insemination (IUI) of a Gonal-f Low-dose Step-up Regimen","status":"TERMINATED","sponsor":"Merck KGaA, Darmstadt, Germany","isPivotal":false,"enrollment":30,"indication":"Infertility","completionDate":"2010-09"},{"nctId":"NCT03254641","phase":"N/A","title":"Calciotropic Effects After HCG Stimulation Test","status":"COMPLETED","sponsor":"Martin Blomberg Jensen","isPivotal":false,"enrollment":242,"indication":"Hypogonadism, Male","completionDate":"2021-10-06"},{"nctId":"NCT00839319","phase":"Phase 1","title":"Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone (Short Title (HOP-3)","status":"COMPLETED","sponsor":"University of Washington","isPivotal":false,"enrollment":59,"indication":"Healthy Males","completionDate":"2010-11"},{"nctId":"NCT04992468","phase":"Phase 4","title":"Dual Trigger vs.GnRH-a Trigger for Elective Fertility Preservation. A Randomized Controlled Trial","status":"COMPLETED","sponsor":"Fundación Santiago Dexeus Font","isPivotal":false,"enrollment":136,"indication":"Infertility","completionDate":"2023-04-25"},{"nctId":"NCT02197208","phase":"NA","title":"A Randomized Controlled Comparison of Spontaneous Natural Cycles and Human Chorionic Gonadotrophin-induced Natural Cycles in Frozen-thawed Embryos Transfer","status":"COMPLETED","sponsor":"The University of Hong Kong","isPivotal":false,"enrollment":300,"indication":"Subfertility, Pregnancy","completionDate":"2015-12"},{"nctId":"NCT06486415","phase":"NA","title":"Serial Measurement of Beta-Human Chorionic Gonadotropin (BHCG) Values During the Day in the Diagnosis of Ectopic Pregnancy","status":"NOT_YET_RECRUITING","sponsor":"Acibadem University","isPivotal":false,"enrollment":20,"indication":"Ectopic Pregnancy, hCG","completionDate":"2025-04-01"},{"nctId":"NCT02355925","phase":"Phase 3","title":"Evaluation the Effect of Intrauterine Injection of Human Chorionic Gonadotropin Injection (hCG) Before Frozen Embryo Transfer on Implantation, Clinical Pregnancy and Miscarriage Rates: Double Blind Ra","status":"COMPLETED","sponsor":"Royan Institute","isPivotal":true,"enrollment":180,"indication":"Infertility","completionDate":"2018-12"},{"nctId":"NCT00663416","phase":"Phase 2","title":"A Phase IIb Prospective, Randomized, Double-blind, Placebo Controlled Study of NTx™-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients (REGENESIS)","status":"TERMINATED","sponsor":"Stem Cell Therapeutics Corp.","isPivotal":false,"enrollment":134,"indication":"Stroke","completionDate":"2009-01"},{"nctId":"NCT04446845","phase":"Phase 4","title":"Double vs. Single Stimulation in Young Poor Prognosis Patients Followed by a Fresh Embryo Transfer. A Randomized Clinical Trial","status":"COMPLETED","sponsor":"Fundación Santiago Dexeus Font","isPivotal":false,"enrollment":120,"indication":"Infertility","completionDate":"2023-05-02"},{"nctId":"NCT04852029","phase":"NA","title":"Prospective Assessment of Impact of Personalized Dosing of Low-dose Human Chorionic Gonadotropin (hCG) on in Vitro Fertilization (IVF) Outcomes","status":"TERMINATED","sponsor":"Reproductive Medicine Associates of New Jersey","isPivotal":false,"enrollment":12,"indication":"Infertility, Female","completionDate":"2021-12-31"},{"nctId":"NCT05370794","phase":"N/A","title":"Is in Vitro Maturation of Oocytes Influenced by the Origin of Gonadotropins Used in Maturation Medium: is There a Difference in Efficiency When Using Urinary Versus Recombinant Produced Follicle Stimu","status":"UNKNOWN","sponsor":"Universitair Ziekenhuis Brussel","isPivotal":false,"enrollment":35,"indication":"In Vitro Maturation of Oocytes","completionDate":"2023-06-30"},{"nctId":"NCT03785574","phase":"NA","title":"Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule，A Prospective Multicentre Randomized Controlled Trial","status":"RECRUITING","sponsor":"Women's Hospital School Of Medicine Zhejiang University","isPivotal":false,"enrollment":30,"indication":"Hydatidiform Mole, Gestational Trophoblastic Neoplasia","completionDate":"2030-09-01"},{"nctId":"NCT06418347","phase":"Phase 3","title":"Effect of Alpha-Lipoic Acid Supplementation on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females Treated With Letrozole","status":"UNKNOWN","sponsor":"Ain Shams University","isPivotal":true,"enrollment":150,"indication":"Polycystic Ovary Syndrome, Infertility, Female","completionDate":"2025-12-01"},{"nctId":"NCT00697255","phase":"Phase 2","title":"A Phase II, Randomized, Controlled, Open-label, Feasibility Trial to Evaluate if a Single or Repeated Dose of Org 36286 (Corifollitropin Alfa) Followed by a Low Daily Dose of Either hCG or Recombinant","status":"TERMINATED","sponsor":"Organon and Co","isPivotal":false,"enrollment":8,"indication":"Ovulation Induction","completionDate":"2008-05-15"},{"nctId":"NCT01112358","phase":"Phase 2","title":"Lutropin Alfa (Luveris®) in Women at Risk of Poor Response Suppressed With Cetrorelix: an Exploratory Trial","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","isPivotal":false,"enrollment":58,"indication":"Ovarian Stimulation","completionDate":"2007-01-30"},{"nctId":"NCT00223860","phase":"NA","title":"Provocative Testing Using LHRH and hCG of the Pituitary-Gonadal Axis in Persons With Spinal Cord Injury","status":"COMPLETED","sponsor":"US Department of Veterans Affairs","isPivotal":false,"enrollment":100,"indication":"Hypogonadism, Spinal Cord Injury","completionDate":"2007-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"icon":"","route":"","frequency":"","formulation":""},"formularyStatus":[],"apiManufacturers":[],"developmentCodes":[],"ownershipHistory":[],"therapeuticAreas":["Other"],"biosimilarFilings":[],"firstApprovalDate":"","companionDiagnostics":[],"firstApprovalCountry":null,"genericManufacturerList":[],"modality":"Small molecule","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":false,"safety":false,"trials":true,"score":1}}