{"id":"nortase","safety":{"commonSideEffects":[{"rate":null,"effect":"Infusion-related reactions"},{"rate":null,"effect":"Potential matrix degradation-related toxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"NORTASE functions as a matrix-degrading enzyme, likely a collagenase or similar protease, designed to remodel the tumor microenvironment by breaking down collagen and other structural proteins. By reducing the physical barrier of the extracellular matrix, the drug aims to enhance penetration of chemotherapeutic agents and checkpoint inhibitors while facilitating immune cell infiltration into previously inaccessible tumor regions.","oneSentence":"NORTASE is an enzyme-based therapeutic that degrades extracellular matrix components to improve drug penetration and immune cell infiltration in solid tumors.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:23:21.086Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Solid tumors (in combination with immunotherapy or chemotherapy)"}]},"trialDetails":[{"nctId":"NCT06058442","phase":"PHASE3","title":"The Pancreatic Enzymes After Gastrectomy Trial","status":"RECRUITING","sponsor":"University of Leipzig","startDate":"2024-01-24","conditions":"Gastrectomy","enrollment":188}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"NORTASE®","genericName":"NORTASE®","companyName":"University of Leipzig","companyId":"university-of-leipzig","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NORTASE is an enzyme-based therapeutic that degrades extracellular matrix components to improve drug penetration and immune cell infiltration in solid tumors. Used for Solid tumors (in combination with immunotherapy or chemotherapy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}