{"id":"normethadone","rwe":[],"tags":[{"label":"normethadone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Mu-type opioid receptor","category":"target"},{"label":"OPRM1","category":"gene"},{"label":"DRD3","category":"gene"},{"label":"DRD2","category":"gene"},{"label":"R05DA06","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Opioid","category":"pharmacology"},{"label":"Antitussive Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Narcotics","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"mepidon","offLabel":[],"synonyms":["normethadone","desmethylmethadone","mepidon","noramidone","normedon","phenyldimazone"],"timeline":[],"approvals":[],"brandName":"Mepidon","ecosystem":[],"mechanism":{"target":"D(2) dopamine receptor, D(3) dopamine receptor, Mu-type opioid receptor","targets":[{"gene":"OPRM1","source":"DrugCentral","target":"Mu-type opioid receptor","protein":"Mu-type opioid receptor"},{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"}],"modality":"Small Molecule","drugClass":"normethadone","explanation":"Imagine your brain has special locks that control how much pain you feel. Mepidon is a key that fits into one of these locks, which helps to turn down the pain signal. This can provide relief from pain, but it's a complex process that involves many different parts of the brain and body.","oneSentence":"Mepidon works by binding to the mu-type opioid receptor in the brain, which can help to reduce pain perception.","technicalDetail":"Mepidon exerts its effects by selectively binding to the mu-type opioid receptor (MOR), a G protein-coupled receptor that plays a critical role in pain modulation and reward processing."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Normethadone","title":"Normethadone","extract":"Normethadone, also known as desmethylmethadone or phenyldimazone, is a synthetic opioid analgesic and antitussive agent.\nNormethadone is listed under the Single Convention on Narcotic Drugs 1961 and is a Schedule I Narcotic controlled substance in the United States, with a DEA ACSCN of 9635 and an annual manufacturing quota of 2 grams. The salts in use are the hydrobromide, hydrochloride (0.890), methyliodide (0.675), oxalate (0.766), picrate (0.563), and the 2,6-ditertbutylnapthalindisulphonate (0.480)."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1969","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NORMETHADONE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Normethadone","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T13:02:51.604318","biosimilars":[],"competitors":[{"drugName":"hydrocodone","drugSlug":"hydrocodone","fdaApproval":"1943-03-23","patentExpiry":"Sep 13, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"codeine","drugSlug":"codeine","fdaApproval":"1952-01-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"morphine","drugSlug":"morphine","fdaApproval":"","patentExpiry":"Mar 12, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"dextromethorphan","drugSlug":"dextromethorphan","fdaApproval":"1957-12-03","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"normethadone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrocodone","brandName":"hydrocodone","genericName":"hydrocodone","approvalYear":"1943","relationship":"same-class"},{"drugId":"codeine","brandName":"codeine","genericName":"codeine","approvalYear":"1952","relationship":"same-class"},{"drugId":"morphine","brandName":"morphine","genericName":"morphine","approvalYear":"","relationship":"same-class"},{"drugId":"dextromethorphan","brandName":"dextromethorphan","genericName":"dextromethorphan","approvalYear":"1957","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"004624","UNII":"KR2L2A68XL","CHEBI":"CHEBI:135242","INN_ID":"467","RXNORM":"32009","UMLSCUI":"C0069008","ChEMBL_ID":"CHEMBL346331","KEGG_DRUG":"D07384","DRUGBANK_ID":"DB11609","PUBCHEM_CID":"10090","SECONDARY_CAS_RN":"111750-68-6","MESH_SUPPLEMENTAL_RECORD_UI":"C005845"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":10,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"R05DA06","allCodes":["R05DA06"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mepidon is a small molecule with synonyms including EUCOPON, HOECHST 10582, and ISOMETHADONE I.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}