{"id":"normale-saline-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Fluid overload / pulmonary edema"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Phlebitis at infusion site"}]},"_chembl":{"chemblId":"CHEMBL2108251","moleculeType":"Oligosaccharide"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Normal saline (0.9% NaCl) is an isotonic crystalloid solution that maintains osmotic balance with blood plasma, preventing cell lysis or crenation. It is used to restore intravascular volume, maintain electrolyte homeostasis, and serve as a vehicle for drug delivery. The solution contains sodium and chloride ions at physiological concentrations (approximately 154 mEq/L each).","oneSentence":"Normal saline solution provides isotonic fluid replacement and electrolyte balance by delivering 0.9% sodium chloride in water to match physiological osmolarity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:23:21.058Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fluid resuscitation and volume replacement in dehydration"},{"name":"Maintenance of electrolyte balance in hospitalized patients"},{"name":"Vehicle for intravenous drug administration"}]},"trialDetails":[{"nctId":"NCT02819518","phase":"PHASE3","title":"Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs. Placebo Plus Chemotherapy for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple Negative Breast Cancer (MK-3475-355/KEYNOTE-355)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2016-07-27","conditions":"Triple Negative Breast Cancer (TNBC)","enrollment":882},{"nctId":"NCT02736812","phase":"PHASE3","title":"Pre-hospital Administration of Lyophilized Plasma for Post-traumatic Coagulopathy Treatment (PREHO-PLYO)","status":"COMPLETED","sponsor":"French Defence Health Service","startDate":"2016-04-01","conditions":"Shock Hemorrhagic","enrollment":140},{"nctId":"NCT01378390","phase":"PHASE3","title":"Safety and Efficacy of Adipose-Derived Stem Cells to Treat Complex Perianal Fistulas Patients With Crohn's Disease","status":"TERMINATED","sponsor":"Tigenix S.A.U.","startDate":"2008-12","conditions":"Complex Perianal Fistula, Crohn Disease","enrollment":56},{"nctId":"NCT02414555","phase":"PHASE4","title":"Perioperative Fluid Management in Patients Receiving Major Abdominal Surgery - Effects of Normal Saline Versus an Acetate Buffered Balanced Infusion Solution on the Necessity of Catecholamines for Cardiocirculatory Support","status":"TERMINATED","sponsor":"Medical University of Vienna","startDate":"2015-03","conditions":"Critical Illness","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Normale Saline Solution","genericName":"Normale Saline Solution","companyName":"Merck Sharp & Dohme LLC","companyId":"merck-sharp-dohme-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Normal saline solution provides isotonic fluid replacement and electrolyte balance by delivering 0.9% sodium chloride in water to match physiological osmolarity. Used for Fluid resuscitation and volume replacement in dehydration, Maintenance of electrolyte balance in hospitalized patients, Vehicle for intravenous drug administration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}