{"id":"normal-saline-pyloric-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reaction"},{"rate":null,"effect":"Temporary increased gastric outlet obstruction"},{"rate":null,"effect":"Perforation risk"}]},"_chembl":{"chemblId":"CHEMBL2108783","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a minimally invasive intervention where sterile normal saline is injected directly into the pyloric sphincter muscle to induce localized swelling and mechanical obstruction relief. The saline causes tissue edema and disruption of the pyloric muscle fibers, which can temporarily widen the pyloric opening or reduce muscle tone. This approach is used as an alternative to surgical pyloromyotomy in select cases of infantile hypertrophic pyloric stenosis.","oneSentence":"Normal saline injection into the pyloric muscle causes mechanical disruption and edema that temporarily obstructs gastric outlet flow, reducing symptoms of pyloric stenosis.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:41:37.831Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infantile hypertrophic pyloric stenosis"}]},"trialDetails":[{"nctId":"NCT06721520","phase":"PHASE2, PHASE3","title":"Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy","status":"RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2024-12-03","conditions":"Esophageal Cancer Surgery, Esophagectomy, Delayed Gastric Emptying Following Procedure","enrollment":170},{"nctId":"NCT06121752","phase":"NA","title":"Device Assisted Full Thickness Resection Versus Endoscopic Submucosal Dissection for Duodenal Neuroendocrine Tumors","status":"UNKNOWN","sponsor":"Asian Institute of Gastroenterology, India","startDate":"2023-11-10","conditions":"Neuroendocrine Tumors","enrollment":54},{"nctId":"NCT03701919","phase":"PHASE4","title":"Botulinum Toxin Pyloroplasty to Reduce Postoperative Nausea and Vomiting After Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Albany Medical College","startDate":"2019-01-07","conditions":"Bariatric Surgery, Postoperative Nausea and Vomiting","enrollment":84},{"nctId":"NCT03126513","phase":"NA","title":"Gastric Per Oral Endoscopic Myotomy (G-POEM) in Refractory Gastroparesis","status":"COMPLETED","sponsor":"Coordinación de Investigación en Salud, Mexico","startDate":"2017-04-01","conditions":"Gastroparesis Postoperative, Gastroparesis Due to Diabetes Mellitus, Idiopathic Gastric Stasis","enrollment":82},{"nctId":"NCT03331965","phase":"PHASE2","title":"Metoclopramide Versus Placebo for GJ Placement","status":"COMPLETED","sponsor":"Duke University","startDate":"2018-04-09","conditions":"Radiation Exposure, Enteral Nutrition","enrollment":110},{"nctId":"NCT02779920","phase":"NA","title":"Feasibility of Endoscopic Pylorotomy in the Treatment of Refractory Gastroparesis, Pilot Study.","status":"COMPLETED","sponsor":"University Hospital, Limoges","startDate":"2016-04","conditions":"Gastroparesis","enrollment":20},{"nctId":"NCT03729505","phase":"NA","title":"Impact of Pyloric Injection of Magnesium Sulfate and Lidocaine Mixture on Outcome After Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2017-07-01","conditions":"Morbid Obesity","enrollment":70},{"nctId":"NCT00372970","phase":"NA","title":"Placebo Controlled Trial of Botulinum Toxin for Gastroparesis","status":"COMPLETED","sponsor":"Temple University","startDate":"2003-07","conditions":"Gastroparesis","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Normal saline pyloric injection","genericName":"Normal saline pyloric injection","companyName":"Albany Medical College","companyId":"albany-medical-college","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Normal saline pyloric injection is used to treat conditions such as gastroparesis, neuroendocrine tumors, morbid obesity, gastroparesis postoperative, and gastroparesis due to diabetes mellitus. The exact mechanism of normal saline pyloric injection is unknown, but it is administered as an injection of a solution that is chemically similar to lactated Ringer's solution.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}