{"id":"normal-saline-gargle","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild throat irritation"},{"rate":null,"effect":"Temporary discomfort during gargling"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Normal saline (0.9% sodium chloride solution) acts as a gentle irrigant that mechanically removes debris, mucus, and microorganisms from the throat. The isotonic saline solution helps reduce inflammation and irritation by maintaining osmotic balance in mucosal tissues, while the gargling action itself provides physical cleansing of the pharyngeal region.","oneSentence":"Normal saline gargle provides mechanical cleansing and osmotic effects to soothe the throat and reduce microbial load in the oral and pharyngeal cavity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:46.787Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sore throat relief and symptomatic management"},{"name":"Oral and pharyngeal hygiene"},{"name":"Post-operative throat care"}]},"trialDetails":[{"nctId":"NCT07461155","phase":"EARLY_PHASE1","title":"Stingless Bee Honey Mouth Rinse on Gingivitis","status":"NOT_YET_RECRUITING","sponsor":"Ministry of Higher Education, Malaysia","startDate":"2026-07-06","conditions":"Gingivitis","enrollment":60},{"nctId":"NCT07402720","phase":"NA","title":"Clinical Effectiveness Of Polishing Brush Compared To Ceramic Soft Tissue Trimming Bur In Gingival Depigmentation","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-11-01","conditions":"Gingival Hyperpigmentation","enrollment":20},{"nctId":"NCT06726876","phase":"PHASE3","title":"Therapeutic Effect of Manuka Honey Oral Rinse in Periodontitis Patients Undergoing Hemodialysis","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-10-01","conditions":"Periodontitis, Hemodialysis","enrollment":150},{"nctId":"NCT07269171","phase":"NA","title":"The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery","status":"NOT_YET_RECRUITING","sponsor":"Saglik Bilimleri Universitesi","startDate":"2025-12-01","conditions":"Oral Health Care","enrollment":15},{"nctId":"NCT04802408","phase":"PHASE2, PHASE3","title":"SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"Milton S. 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Used for Sore throat relief and oral hygiene, Post-operative throat care, Symptomatic relief of minor throat irritation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}