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Control","status":"TERMINATED","sponsor":"Joshua Herskovic","startDate":"2015-11-01","conditions":"Pain, Postoperative","enrollment":14},{"nctId":"NCT03627884","phase":"PHASE4","title":"Outcomes of the Use of Sodium Bicarbonate (8.4%) Solution as a Catheter Lock Solution to Prevent Hemodialysis Catheter Loss Due to Lumen Clot Formation","status":"COMPLETED","sponsor":"Coney Island Hospital, Brooklyn, NY","startDate":"2016-10-01","conditions":"End Stage Renal Disease, Acute Renal Failure, Hemodialysis Catheter Infection","enrollment":451},{"nctId":"NCT02227329","phase":"PHASE1, PHASE2","title":"Prophylactic Ethanol Lock Therapy (ELT) in Patients on Home Parenteral Nutrition","status":"TERMINATED","sponsor":"Mayo Clinic","startDate":"2014-07","conditions":"Catheter-related Bloodstream Infection (CRBSI) Nos, Bloodstream Infection Due to Central Venous Catheter, Bloodstream Infection Due to Hickman Catheter","enrollment":39},{"nctId":"NCT01263574","phase":"PHASE2","title":"Trial of 70% Ethanol Versus Heparin to Reduce the Rate of Central Line Infections in Children With Short Bowel Syndrome","status":"WITHDRAWN","sponsor":"Boston Children's Hospital","startDate":"2011-02","conditions":"Catheter Related Infections, Short Bowel Syndrome","enrollment":""},{"nctId":"NCT02279121","phase":"NA","title":"ATAPAC Study (TauroLock Activity in Adult Cancer Patients)","status":"COMPLETED","sponsor":"Centre Hospitalier Régional Metz-Thionville","startDate":"2014-11","conditions":"Catheter-Related Infections","enrollment":162},{"nctId":"NCT01948245","phase":"PHASE4","title":"Clinical Trial Comparing Catheter Lock Solutions TaurolockTMHep 100 and Heparin 100 IE/ml.","status":"UNKNOWN","sponsor":"Palle Bekker Jeppesen","startDate":"2013-10","conditions":"Catheter-related Bloodstream Infection (CRBSI) Nos","enrollment":42},{"nctId":"NCT02221024","phase":"PHASE3","title":"Normal Saline Flushes at 12 vs 24 Hours Intervals for Maintaining Peripheral Intravenous Catheters 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Virginia","startDate":"2011-02","conditions":"Central Lines in ICU Patients","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"crossReferences":{"chemblId":"CHEMBL2108251"},"_approvalHistory":[],"publicationCount":18,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Normal Saline Catheter Lock Solution","genericName":"Normal Saline Catheter Lock Solution","companyName":"Coney Island Hospital, Brooklyn, NY","companyId":"coney-island-hospital-brooklyn-ny","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Normal saline catheter lock solution prevents blood clot formation and bacterial biofilm growth within central venous catheters by maintaining patency with sterile isotonic sodium chloride solution. Used for Prevention of central venous catheter thrombosis and occlusion, Maintenance of catheter patency between uses.","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T04:59:45.933429+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}