{"id":"norgestrienone","rwe":[{"pmid":"1836415","year":"1991","title":"[Compared action of norethindrone and various steroids on Müller ducts of the female chick embryo].","finding":"","journal":"Comptes rendus des seances de la Societe de biologie et de ses filiales","studyType":"Clinical Study"},{"pmid":"3056584","year":"1988","title":"[Follicular ovarian cysts appearing during progestin or estroprogestin oral contraception at low doses].","finding":"","journal":"Bulletin de l'Academie nationale de medecine","studyType":"Clinical Study"},{"pmid":"2963296","year":"1987","title":"[Hereditary angioneurotic edema: norgestrienone is not effective in every case].","finding":"","journal":"Presse medicale (Paris, France : 1983)","studyType":"Clinical Study"},{"pmid":"2948181","year":"1986","title":"[Norgestrienone, a possible therapeutic agent in hereditary angioneurotic edema].","finding":"","journal":"Presse medicale (Paris, France : 1983)","studyType":"Clinical Study"},{"pmid":"6894112","year":"1980","title":"Experimental study of cervical blockage induced by continuous low-dose oral progestogens.","finding":"","journal":"Contraception","studyType":"Clinical Study"}],"tags":[{"label":"norgestrienone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"G03AC07","category":"atc"},{"label":"Active","category":"status"},{"label":"Contraceptive Agents","category":"pharmacology"},{"label":"Contraceptive Agents, Female","category":"pharmacology"},{"label":"Contraceptives, Oral, Synthetic","category":"pharmacology"},{"label":"Reproductive Control Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["norgestrienone"],"offLabel":[],"synonyms":["norgestrienone"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"norgestrienone","explanation":"Imagine your body has locks that only progesterone can open. Norgestrienone is a key that fits into those locks, allowing it to turn on or off certain processes in the body. This can help regulate things like hormone levels and menstrual cycles.","oneSentence":"Norgestrienone works by binding to progesterone receptors in the body, mimicking the effects of the natural hormone progesterone.","technicalDetail":"Norgestrienone exerts its effects by binding to progesterone receptors (PR) in a manner similar to natural progesterone, influencing gene expression and cellular activity in tissues such as the uterus, breast, and hypothalamus."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3205","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=NORGESTRIENONE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NORGESTRIENONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:09:21.960545","biosimilars":[],"competitors":[{"drugName":"norethisterone","drugSlug":"norethisterone","fdaApproval":"1962-05-21","relationship":"same-class"},{"drugName":"levonorgestrel","drugSlug":"levonorgestrel","fdaApproval":"1968-04-16","patentExpiry":"Sep 7, 2040","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"megestrol acetate","drugSlug":"megestrol-acetate","fdaApproval":"1971-08-18","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"medroxyprogesterone","drugSlug":"medroxyprogesterone","fdaApproval":"1959-06-18","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"etonogestrel","drugSlug":"etonogestrel","fdaApproval":"2001-10-03","patentExpiry":"Sep 28, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"desogestrel","drugSlug":"desogestrel","fdaApproval":"1992-12-10","relationship":"same-class"},{"drugName":"drospirenone","drugSlug":"drospirenone","fdaApproval":"2019-05-23","patentExpiry":"Jun 28, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"norgestrienone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"norethisterone","brandName":"norethisterone","genericName":"norethisterone","approvalYear":"1962","relationship":"same-class"},{"drugId":"levonorgestrel","brandName":"levonorgestrel","genericName":"levonorgestrel","approvalYear":"1968","relationship":"same-class"},{"drugId":"megestrol-acetate","brandName":"megestrol acetate","genericName":"megestrol acetate","approvalYear":"1971","relationship":"same-class"},{"drugId":"medroxyprogesterone","brandName":"medroxyprogesterone","genericName":"medroxyprogesterone","approvalYear":"1959","relationship":"same-class"},{"drugId":"etonogestrel","brandName":"etonogestrel","genericName":"etonogestrel","approvalYear":"2001","relationship":"same-class"},{"drugId":"desogestrel","brandName":"desogestrel","genericName":"desogestrel","approvalYear":"1992","relationship":"same-class"},{"drugId":"drospirenone","brandName":"drospirenone","genericName":"drospirenone","approvalYear":"2019","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05570786","phase":"PHASE2","title":"Subdermal Implant-bioabsorbable Gestrinone Pellet for Endometriosis Pelvic Pain Treatment","status":"COMPLETED","sponsor":"Science Valley Research Institute","startDate":"2023-02-13","conditions":["Deep Endometriosis","Pelvic Pain"],"enrollment":100,"completionDate":"2025-10-31"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000167402","NDDF":"005626","UNII":"89386PYU9O","INN_ID":"2373","RXNORM":"7519","UMLSCUI":"C0028369","ChEMBL_ID":"CHEMBL1908319","KEGG_DRUG":"D07220","DRUGBANK_ID":"DB13563","PUBCHEM_CID":"13313","MESH_DESCRIPTOR_UI":"D009645"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":31,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G03AC07","allCodes":["G03AC07"]},"biosimilarFilings":[],"recentPublications":[{"date":"1991","pmid":"1836415","title":"[Compared action of norethindrone and various steroids on Müller ducts of the female chick embryo].","journal":"Comptes rendus des seances de la Societe de biologie et de ses filiales"},{"date":"1988 May","pmid":"3056584","title":"[Follicular ovarian cysts appearing during progestin or estroprogestin oral contraception at low doses].","journal":"Bulletin de l'Academie nationale de medecine"},{"date":"1987 Dec 12","pmid":"2963296","title":"[Hereditary angioneurotic edema: norgestrienone is not effective in every case].","journal":"Presse medicale (Paris, France : 1983)"},{"date":"1986 Nov 15","pmid":"2948181","title":"[Norgestrienone, a possible therapeutic agent in hereditary angioneurotic edema].","journal":"Presse medicale (Paris, France : 1983)"},{"date":"1980 Nov","pmid":"6894112","title":"Experimental study of cervical blockage induced by continuous low-dose oral progestogens.","journal":"Contraception"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"NORGESTRIENONE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norgestrienone is a synthetic progestin, a type of small molecule drug belonging to the norgestrienone class. Its exact target and mechanism of action are unknown, but it is believed to work by mimicking the effects of progesterone in the body. Norgestrienone is not FDA-approved for any indications, and its commercial status, patent status, and availability of generic manufacturers are also unknown. As a result, there is limited information available on its safety profile and potential side effects. Further research is needed to fully understand the properties and potential uses of norgestrienone.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}