{"id":"norfloxacin-synbiotic","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Tendinopathy (fluoroquinolone class effect)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Norfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, preventing DNA replication and causing bacterial cell death. The synbiotic component provides live beneficial bacteria and their nutritional substrates to restore healthy gut flora, potentially reducing antibiotic-associated dysbiosis and improving treatment outcomes and tolerability.","oneSentence":"Norfloxacin kills pathogenic bacteria via DNA gyrase inhibition, while the synbiotic (probiotics + prebiotics) restores and maintains beneficial gut microbiota.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:23:24.183Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections (likely urinary tract infections or gastrointestinal infections) with concurrent microbiota restoration"}]},"trialDetails":[{"nctId":"NCT00947336","phase":"PHASE3","title":"Evaluation of Safety & Efficacy of Synbiotic on the Incidence and Recurrence of Spontaneous Bacterial Peritonitis (SBP) in Cirrhotics","status":"COMPLETED","sponsor":"Govind Ballabh Pant Hospital","startDate":"2005-04","conditions":"Cirrhosis With Ascites","enrollment":110}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Norfloxacin + Synbiotic","genericName":"Norfloxacin + Synbiotic","companyName":"Govind Ballabh Pant Hospital","companyId":"govind-ballabh-pant-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norfloxacin kills pathogenic bacteria via DNA gyrase inhibition, while the synbiotic (probiotics + prebiotics) restores and maintains beneficial gut microbiota. Used for Bacterial infections (likely urinary tract infections or gastrointestinal infections) with concurrent microbiota restoration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}