{"id":"norethynodrel","rwe":[],"tags":[{"label":"norethynodrel","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Progesterone receptor","category":"target"},{"label":"PGR","category":"gene"},{"label":"G03FA09","category":"atc"},{"label":"Active","category":"status"},{"label":"Contraception","category":"indication"},{"label":"Endometriosis","category":"indication"},{"label":"Female hypogonadism syndrome","category":"indication"},{"label":"Menorrhagia","category":"indication"},{"label":"Gd Searle Llc","category":"company"},{"label":"Approved 1960s","category":"decade"},{"label":"Contraceptive Agents","category":"pharmacology"},{"label":"Contraceptive Agents, Female","category":"pharmacology"},{"label":"Contraceptive Agents, Hormonal","category":"pharmacology"},{"label":"Contraceptives, Oral, Hormonal","category":"pharmacology"},{"label":"Contraceptives, Oral, Synthetic","category":"pharmacology"},{"label":"Reproductive Control Agents","category":"pharmacology"}],"phase":"marketed","safety":{"drugInteractions":[{"url":"/drug/rifabutin","drug":"rifabutin","action":"Monitor closely","effect":"May interact with Rifabutin","source":"DrugCentral","drugSlug":"rifabutin"},{"url":"/drug/rifampicin","drug":"rifampicin","action":"Avoid combination","effect":"May interact with Rifampin","source":"DrugCentral","drugSlug":"rifampicin"},{"url":"/drug/rifapentine","drug":"rifapentine","action":"Monitor closely","effect":"May interact with Rifapentine","source":"DrugCentral","drugSlug":"rifapentine"}]},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=NORETHYNODREL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:19:03.459522+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Norethynodrel","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T00:19:11.827172+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:19:10.412925+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NORETHYNODREL","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:19:11.239599+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Progesterone receptor agonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:19:11.826607+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1387/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:19:11.709907+00:00"}},"allNames":"noretynodrel","offLabel":[],"synonyms":["norethynodrel","norethinodrel","noretynodrel"],"timeline":[{"date":"1961-03-09","type":"positive","source":"DrugCentral","milestone":"FDA approval (Gd Searle Llc)"}],"approvals":[{"date":"1961-03-09","orphan":false,"company":"GD SEARLE LLC","regulator":"FDA"}],"brandName":"Noretynodrel","ecosystem":[{"indication":"Contraception","otherDrugs":[{"name":"desogestrel","slug":"desogestrel","company":"Organon Usa Inc"},{"name":"dienogest","slug":"dienogest","company":""},{"name":"drospirenone","slug":"drospirenone","company":"Exeltis Usa Inc"},{"name":"estradiol","slug":"estradiol","company":"Bristol Myers Squibb"}],"globalPrevalence":null},{"indication":"Endometriosis","otherDrugs":[{"name":"danazol","slug":"danazol","company":""},{"name":"elagolix","slug":"elagolix","company":"Abbvie Inc "},{"name":"goserelin","slug":"goserelin","company":"Astrazeneca"},{"name":"leuprorelin","slug":"leuprorelin","company":""}],"globalPrevalence":null},{"indication":"Female hypogonadism syndrome","otherDrugs":[{"name":"estradiol","slug":"estradiol","company":"Bristol Myers Squibb"},{"name":"estradiol cypionate","slug":"estradiol-cypionate","company":"Pharmacia And Upjohn"},{"name":"estradiol valerate","slug":"estradiol-valerate","company":"Par Sterile Products"},{"name":"estrone sulphate","slug":"estrone-sulphate","company":"Pharmacia And Upjohn"}],"globalPrevalence":null},{"indication":"Menorrhagia","otherDrugs":[{"name":"levonorgestrel","slug":"levonorgestrel","company":"Wyeth Pharms"},{"name":"meclofenamic acid","slug":"meclofenamic-acid","company":""},{"name":"mestranol","slug":"mestranol","company":""},{"name":"norethisterone","slug":"norethisterone","company":"Ortho Mcneil Pharm"}],"globalPrevalence":null}],"mechanism":{"target":"Progesterone receptor","novelty":"Follow-on","targets":[{"gene":"PGR","source":"DrugCentral","target":"Progesterone receptor","protein":"Progesterone receptor"}],"modality":"Small Molecule","drugClass":"norethynodrel","explanation":"","oneSentence":"","technicalDetail":"Noretynodrel acts as a selective progesterone receptor modulator (SPRM), binding to the progesterone receptor with high affinity and activating it, which leads to the regulation of gene expression and subsequent physiological effects."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Noretynodrel","title":"Noretynodrel","extract":"Noretynodrel, or norethynodrel, sold under the brand name Enovid among others, is a progestin medication which was previously used in birth control pills and in the treatment of gynecological disorders but is now no longer marketed. It was available both alone and in combination with an estrogen. The medication is taken by mouth.","wiki_history":"==History==\nNoretynodrel was first synthesized by Frank B. Colton of G. D. Searle & Company in 1952, and this was preceded by the synthesis of norethisterone by Luis E. Miramontes and Carl Djerassi of Syntex in 1951. In 1960, noretynodrel, in combination with mestranol (as Enovid), was introduced in the United States as the first oral contraceptive, and the combination of norethisterone and mestranol followed in 1963 as the second oral contraceptive to be introduced.\n\nNoretynodrel was first studied in the treatment of endometriosis in 1961 and was the first progestin to be investigated for the treatment of the condition.","wiki_society_and_culture":"==Society and culture==\n\n===Generic names===\nNoretynodrel is the  of the drug while norethynodrel is its  and . It is also known by its developmental code name SC-4642.\n\n===Availability===\nNoretynodrel is no longer available in any formulation in the U.S., nor does it appear to still be marketed in any other country."},"commercial":{"launchDate":"1961","_launchSource":"DrugCentral (FDA 1961-03-09, GD SEARLE LLC)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1965","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NORETHYNODREL","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Noretynodrel","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T15:06:35.079590","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:19:13.643129+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"norethisterone","drugSlug":"norethisterone","fdaApproval":"1962-05-21","relationship":"same-class"},{"drugName":"hydroxyprogesterone caproate","drugSlug":"hydroxyprogesterone-caproate","fdaApproval":"1975-10-03","genericCount":2,"patentStatus":"Off-patent — generic 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