{"id":"norethindrone-enanthate","rwe":[{"pmid":"41169120","year":"2025","title":"Evaluation of pharmacokinetic interactions between long-acting cabotegravir or emtricitabine/tenofovir disoproxil fumarate and hormonal contraceptive agents: a tertiary analysis of South African participants in HPTN 084.","finding":"","journal":"Journal of the International AIDS Society","studyType":"Clinical Study"},{"pmid":"40260892","year":"2025","title":"Brief Report: Exploratory Substudy of a Phase 2 Trial to Evaluate the Pharmacokinetic Effect of Once-Monthly Islatravir on Long-Acting Reversible Contraceptives.","finding":"","journal":"Journal of acquired immune deficiency syndromes (1999)","studyType":"Clinical Study"},{"pmid":"29201392","year":"2016","title":"Trends in contraceptive practices among women in reproductive age at a health facility in Ghana: 2011-2013.","finding":"","journal":"Contraception and reproductive medicine","studyType":"Clinical Study"},{"pmid":"17982332","year":"2007","title":"Injectable contraception.","finding":"","journal":"Clinical obstetrics and gynecology","studyType":"Clinical Study"},{"pmid":"17175547","year":"2007","title":"Prospective study of hormonal contraception and women's risk of HIV infection in South Africa.","finding":"","journal":"International journal of epidemiology","studyType":"Clinical Study"}],"tags":[{"label":"Progestin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Contraceptive Agents","category":"pharmacology"},{"label":"Contraceptive Agents, Female","category":"pharmacology"},{"label":"Contraceptive Agents, Hormonal","category":"pharmacology"},{"label":"Contraceptives, Oral, Hormonal","category":"pharmacology"},{"label":"Contraceptives, Oral, Synthetic","category":"pharmacology"},{"label":"Reproductive Control Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"norigest","offLabel":[],"synonyms":["norethindrone enanthate","norethisterone enanthate","norethisterone heptanoate","norigest","noristerat"],"timeline":[],"approvals":[],"brandName":"Norigest","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Progestin","explanation":"Imagine your body's hormones as a key and lock system. Progesterone is a key that helps regulate the menstrual cycle and other bodily functions. Norigest is a similar key that fits into the same lock, helping to calm down the body's reproductive system and reduce symptoms of certain conditions.","oneSentence":"Norigest works by binding to progesterone receptors in the body, mimicking the effects of the hormone progesterone.","technicalDetail":"Norigest (norethindrone enanthate) exerts its effects by binding to progesterone receptors in target tissues, including the uterus and breast tissue, thereby modulating the transcription of genes involved in the regulation of the menstrual cycle and other reproductive processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1964","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=norethindrone%20enanthate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=norethindrone enanthate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:41:48.489756","biosimilars":[],"competitors":[],"genericName":"norethindrone enanthate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT03901131","phase":"","title":"PROMES: A Clinical Study in Which Researchers Want to Learn More About the Safety Profile of MESIGYNA (Norethisterone Enantate 50 mg and Estradiol Valerate 5 mg) Used as a Medication to Prevent Pregnancy for Adult Women in Reproductive Age in the Peruvian Population at the Outpatient Clinic.","status":"COMPLETED","sponsor":"Bayer","startDate":"2019-08-26","conditions":["Contraceptive"],"enrollment":296,"completionDate":"2022-02-17"},{"nctId":"NCT05362019","phase":"NA","title":"Effects of One-to-one Service on the Continuation and Satisfaction of Contraceptive Use.","status":"UNKNOWN","sponsor":"National Research Institute for Family Planning, China","startDate":"2022-05","conditions":["Contraception Behavior","Contraceptive Usage"],"enrollment":400,"completionDate":"2023-03"},{"nctId":"NCT02038335","phase":"","title":"HIV-Target Cell Response in Women Initiating Various Contraceptive Methods in High HIV-Incidence Areas: Zim CHIC","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2014-02","conditions":["Contraception","HIV","Immune Cells (Mucosal and Systemic)","Microbiota"],"enrollment":451,"completionDate":"2020-12"},{"nctId":"NCT02905890","phase":"PHASE4","title":"The Effect of Norethisterone Enanthate on Recurrent Bacterial Vaginosis","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2017-10-02","conditions":["Bacterial Vaginosis","HIV"],"enrollment":250,"completionDate":"2019-12-20"},{"nctId":"NCT02404038","phase":"NA","title":"A Study to Evaluate the Acceptability and Preference for Contraceptive Options as Proxy for HIV Prevention Methods","status":"UNKNOWN","sponsor":"Desmond Tutu HIV Centre","startDate":"2015-07","conditions":["HIV"],"enrollment":131,"completionDate":"2020-02-28"},{"nctId":"NCT02170038","phase":"PHASE1","title":"Clinical Study Investigating the Conversion of the Contraceptive Compound Norethisterone Within the Body Towards the Contraceptive Compound Ethinylestradiol","status":"COMPLETED","sponsor":"Bayer","startDate":"2014-06","conditions":["Pharmacokinetics"],"enrollment":16,"completionDate":"2015-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"182290","NDDF":"001298","UNII":"HY3S2K0J0F","CHEBI":"CHEBI:34894","VANDF":"4018496","INN_ID":"687","RXNORM":"31984","UMLSCUI":"C0068981","DRUGBANK_ID":"DB14678","PUBCHEM_CID":"229295","SNOMEDCT_US":"126102009","MESH_DESCRIPTOR_UI":"D009640","MESH_SUPPLEMENTAL_RECORD_UI":"C024319"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":138,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Nov","pmid":"41169120","title":"Evaluation of pharmacokinetic interactions between long-acting cabotegravir or emtricitabine/tenofovir disoproxil fumarate and hormonal contraceptive agents: a tertiary analysis of South African participants in HPTN 084.","journal":"Journal of the International AIDS Society"},{"date":"2025 Aug 1","pmid":"40260892","title":"Brief Report: Exploratory Substudy of a Phase 2 Trial to Evaluate the Pharmacokinetic Effect of Once-Monthly Islatravir on Long-Acting Reversible Contraceptives.","journal":"Journal of acquired immune deficiency syndromes (1999)"},{"date":"2016","pmid":"29201392","title":"Trends in contraceptive practices among women in reproductive age at a health facility in Ghana: 2011-2013.","journal":"Contraception and reproductive medicine"},{"date":"2007 Dec","pmid":"17982332","title":"Injectable contraception.","journal":"Clinical obstetrics and gynecology"},{"date":"2007 Feb","pmid":"17175547","title":"Prospective study of hormonal contraception and women's risk of HIV infection in South Africa.","journal":"International journal of epidemiology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Norigest (norethindrone enanthate) is a progestin medication, a small molecule that belongs to the class of progestins. It is used to treat conditions such as endometriosis and fibrocystic breast disease. The commercial status of Norigest is unknown, and it is not clear if it is patented or available as a generic medication. As a progestin, Norigest works by mimicking the effects of progesterone in the body, which can help to regulate the menstrual cycle and reduce symptoms of certain conditions. However, more information is needed to provide a comprehensive summary.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}