{"id":"norethindrone-acetate-nta","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Irregular bleeding"},{"rate":null,"effect":"Weight changes"},{"rate":null,"effect":"Mood changes"}]},"_chembl":{"chemblId":"CHEMBL1201146","moleculeType":"Small molecule","molecularWeight":"340.46"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a progestin, norethindrone acetate acts primarily on progesterone receptors in the hypothalamus and pituitary gland to inhibit the luteinizing hormone (LH) surge, thereby preventing ovulation. It also thickens cervical mucus and alters the endometrial lining to create an inhospitable environment for sperm and embryo implantation. These combined effects make it effective for contraception and management of hormone-dependent conditions.","oneSentence":"Norethindrone acetate is a synthetic progestin that binds to progesterone receptors to suppress ovulation and alter the endometrium for contraceptive and hormonal therapy effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:46.883Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral contraception"},{"name":"Endometriosis"},{"name":"Abnormal uterine bleeding"},{"name":"Hormone replacement therapy"}]},"trialDetails":[{"nctId":"NCT04676061","phase":"PHASE4","title":"Effects of a Progestin on Frequent and/or Prolonged Bleeding With Nexplanon™","status":"TERMINATED","sponsor":"Baylor Research Institute","startDate":"2021-02-11","conditions":"Birth Control, Contraception, Implant","enrollment":51}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Norethindrone acetate (NTA)","genericName":"Norethindrone acetate (NTA)","companyName":"Baylor Research Institute","companyId":"baylor-research-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norethindrone acetate is a synthetic progestin that binds to progesterone receptors to suppress ovulation and alter the endometrium for contraceptive and hormonal therapeutic effects. Used for Oral contraception, Endometriosis, Abnormal uterine bleeding.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}