{"id":"norepinephrine-intra-arteriel-hepatic","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Peripheral ischemia"},{"rate":null,"effect":"Catheter-related complications"}]},"_chembl":{"chemblId":"CHEMBL432","moleculeType":"Small molecule","molecularWeight":"169.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Norepinephrine is an alpha-1 and beta-1 adrenergic agonist that causes vasoconstriction when delivered intra-arterially to the hepatic circulation. This localized vasoconstrictive effect reduces portal pressure and blood flow through esophageal varices, thereby decreasing variceal bleeding. The intra-arterial hepatic route allows for high local drug concentration with potentially lower systemic exposure compared to intravenous administration.","oneSentence":"Norepinephrine administered directly into the hepatic artery increases vasoconstriction and blood pressure locally to reduce bleeding from esophageal varices.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:57:37.065Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute esophageal variceal bleeding (intra-arterial hepatic infusion)"}]},"trialDetails":[{"nctId":"NCT02472249","phase":"PHASE4","title":"Pharmacological Manipulation of Intrahepatic Arterial Blood Flow in HCC","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2016-01","conditions":"Hepatocellular Carcinoma","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Norepinephrine intra-arteriel/hepatic","genericName":"Norepinephrine intra-arteriel/hepatic","companyName":"University Health Network, Toronto","companyId":"university-health-network-toronto","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norepinephrine administered directly into the hepatic artery acts as an alpha and beta adrenergic agonist to increase vasoconstriction and improve regional blood flow and hemodynamics in the liver. Used for Hepatic ischemia or compromised hepatic perfusion (investigational/institutional use).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}