{"id":"norepinephrine-and-vasopressin-for-rescue","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Peripheral vasoconstriction / tissue ischemia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL432","moleculeType":"Small molecule","molecularWeight":"169.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Norepinephrine is a catecholamine that acts on alpha and beta adrenergic receptors to increase heart rate, contractility, and vasoconstriction. Vasopressin (antidiuretic hormone) acts on V1 receptors on vascular smooth muscle to cause vasoconstriction. Together, they are used as rescue vasopressors in critically ill patients with hypotension unresponsive to standard therapies.","oneSentence":"This combination therapy uses norepinephrine and vasopressin to increase blood pressure and peripheral vascular resistance in patients with refractory hypotension or shock.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:28.257Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Refractory hypotension or shock in critically ill patients"},{"name":"Septic shock unresponsive to standard vasopressor therapy"}]},"trialDetails":[{"nctId":"NCT06464510","phase":"PHASE3","title":"Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis","status":"RECRUITING","sponsor":"Hospital do Coracao","startDate":"2024-11-21","conditions":"Septic Shock","enrollment":2800}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Norepinephrine and Vasopressin for Rescue","genericName":"Norepinephrine and Vasopressin for Rescue","companyName":"Hospital do Coracao","companyId":"hospital-do-coracao","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination therapy uses norepinephrine and vasopressin to increase blood pressure and peripheral vascular resistance in patients with refractory hypotension or shock. Used for Refractory hypotension or shock in critically ill patients, Septic shock unresponsive to standard vasopressor therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}