{"id":"norepinephrine-10-g-boluses","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Tissue necrosis (extravasation)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Norepinephrine acts as both a neurotransmitter and sympathomimetic agent, activating alpha-1 adrenergic receptors (causing vasoconstriction) and beta-1 adrenergic receptors (increasing heart rate and contractility). In bolus form, it produces rapid but short-lived hemodynamic effects, making it useful for acute hypotensive episodes. The drug increases systemic vascular resistance and cardiac output, restoring perfusion pressure to vital organs.","oneSentence":"Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase heart rate, cardiac contractility, and peripheral vasoconstriction, thereby raising blood pressure and improving tissue perfusion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:44.727Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute hypotension in critical care settings"},{"name":"Cardiogenic shock"},{"name":"Septic shock (adjunctive therapy)"}]},"trialDetails":[{"nctId":"NCT06885268","phase":"PHASE3","title":"Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery","status":"RECRUITING","sponsor":"Jagiellonian University","startDate":"2025-06-25","conditions":"Blood Pressure Management, Intraoperative Hypotension, Non-cardiac Surgery","enrollment":750},{"nctId":"NCT07259655","phase":"PHASE4","title":"Management of Post-Induction Hypotension in Emergency Abdominal Surgery","status":"TERMINATED","sponsor":"Hopital Charles Nicolle","startDate":"2025-03-06","conditions":"Post-induction Hypotension","enrollment":100},{"nctId":"NCT03773276","phase":"PHASE1, PHASE2","title":"Norepinephrine Boluses in Liver Transplantation","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2018-12-17","conditions":"Living Donor Liver Transplantation, Norepinephrine Bolus, Postperfusion Syndrome","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Norepinephrine (10 µg boluses)","genericName":"Norepinephrine (10 µg boluses)","companyName":"Hopital Charles Nicolle","companyId":"hopital-charles-nicolle","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norepinephrine is a small molecule used in the form of boluses to manage blood pressure, particularly in the context of living donor liver transplantation and postperfusion syndrome. It is administered in 10 µg doses to help regulate blood pressure during these medical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}