{"id":"norco-5milligram-325milligram-tablet","safety":{"commonSideEffects":[{"rate":"25-30","effect":"Dizziness"},{"rate":"20-25","effect":"Lightheadedness"},{"rate":"20-25","effect":"Drowsiness"},{"rate":"15-20","effect":"Nausea"},{"rate":"15-20","effect":"Constipation"},{"rate":"10-15","effect":"Vomiting"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":{"chemblId":"CHEMBL635","moleculeType":"Small molecule","molecularWeight":"358.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydrocodone binds to mu-opioid receptors in the central nervous system to reduce pain perception and increase pain tolerance. Acetaminophen works through multiple mechanisms including inhibition of prostaglandin synthesis and modulation of serotonergic and noradrenergic pathways. Together, these agents provide synergistic analgesia for moderate pain.","oneSentence":"Norco combines hydrocodone (an opioid agonist) with acetaminophen to provide pain relief through central nervous system depression and peripheral analgesic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:35.799Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate pain management"}]},"trialDetails":[{"nctId":"NCT03872843","phase":"PHASE4","title":"Opioid Free Management After Ureteroscopy","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2019-09-19","conditions":"Kidney Stone","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Opioid"],"phase":"marketed","status":"active","brandName":"Norco 5milligram-325milligram Tablet","genericName":"Norco 5milligram-325milligram Tablet","companyName":"Wake Forest University Health Sciences","companyId":"wake-forest-university-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norco 5milligram-325milligram Tablet is a medication used to manage postoperative pain after ureteroscopy, as indicated in a clinical trial for kidney stone treatment. It is a glucocorticoid receptor agonist, a type of small molecule that acts on the glucocorticoid receptor.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}