{"id":"nonoxinol","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Vaginal","category":"route"},{"label":"Aerosol","category":"form"},{"label":"Film","category":"form"},{"label":"Gel","category":"form"},{"label":"Sponge","category":"form"},{"label":"Active","category":"status"},{"label":"Contraception","category":"indication"},{"label":"Personal Prods","category":"company"},{"label":"Approved 1960s","category":"decade"},{"label":"Antispermatogenic Agents","category":"pharmacology"},{"label":"Contraceptive Agents","category":"pharmacology"},{"label":"Contraceptive Agents, Female","category":"pharmacology"},{"label":"Noxae","category":"pharmacology"},{"label":"Reproductive Control Agents","category":"pharmacology"},{"label":"Spermatocidal Agents","category":"pharmacology"},{"label":"Surface-Active Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"Personal Prods","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=nonoxinol","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:34:39.152620+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:34:45.831082+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=nonoxinol","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:34:46.598264+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108472/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:34:47.070637+00:00"}},"allNames":"today","offLabel":[],"synonyms":["nonoxinol","nonoxynol 9","nonoxynol-9","nonoxynol 4,9,15,30"],"timeline":[{"date":"1963-12-10","type":"positive","source":"DrugCentral","milestone":"FDA approval (Personal Prods)"}],"aiSummary":"Today (nonoxinol) is a small molecule contraceptive medication originally developed by Personal Prods and currently owned by the same company. It was FDA approved in 1963 for use in contraception. The commercial status of Today is not explicitly stated, but it is likely to be a branded product given its ownership. Key safety considerations include potential irritation and allergic reactions. As a nonoxinol-based contraceptive, it works by disrupting sperm cell membranes.","approvals":[{"date":"1963-12-10","orphan":false,"company":"PERSONAL PRODS","regulator":"FDA"}],"brandName":"Today","ecosystem":[{"indication":"Contraception","otherDrugs":[{"name":"desogestrel","slug":"desogestrel","company":"Organon Usa Inc"},{"name":"dienogest","slug":"dienogest","company":""},{"name":"drospirenone","slug":"drospirenone","company":"Exeltis Usa Inc"},{"name":"estradiol","slug":"estradiol","company":"Bristol Myers Squibb"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"Nonoxinol-9, the active ingredient in Today, is a nonionic surfactant that disrupts the sperm cell membrane by altering its lipid composition, ultimately leading to sperm cell death and preventing fertilization."},"commercial":{"launchDate":"1963","_launchSource":"DrugCentral (FDA 1963-12-10, PERSONAL PRODS)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5107","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=nonoxinol","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=nonoxinol","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T13:00:52.913633","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:34:49.033462+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"nonoxinol","indications":{"approved":[{"name":"Contraception","source":"DrugCentral","snomedId":13197004,"regulator":"FDA","eligibility":"Adult women of childbearing potential"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07203885","phase":"NA","title":"AI-Assisted Acute Myeloid Leukemia Evaluation With the Leukemia End-to-End Analysis Platform (LEAP) Versus Clinician-Only Assessment","status":"COMPLETED","sponsor":"Harvard Medical School (HMS and HSDM)","startDate":"2025-09-09","conditions":["Acute Promyelocytic Leukemia (APL)","Acute Myeloid Leukaemia (AML)"],"enrollment":10,"completionDate":"2025-10-10"},{"nctId":"NCT03115710","phase":"","title":"The K-Map Study, Global Prevalence of KC","status":"RECRUITING","sponsor":"University Hospital, Geneva","startDate":"2015-12-28","conditions":["Keratoconus"],"enrollment":20000,"completionDate":"2030-02-01"},{"nctId":"NCT06484010","phase":"NA","title":"Effectiveness of SNAPPS in Family Medicine Residency Program","status":"COMPLETED","sponsor":"Hawler Medical University","startDate":"2023-03-15","conditions":["Medical 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Inc.","startDate":"2011-04","conditions":["Contraception"],"enrollment":3389,"completionDate":"2014-06"},{"nctId":"NCT05250882","phase":"NA","title":"Enhanced Perioperative Care for the Prevention of Colorectal Anastomotic Leakage","status":"UNKNOWN","sponsor":"Amsterdam UMC, location VUmc","startDate":"2021-09-05","conditions":["Anastomotic Leak Small Intestine","Anastomotic Leak Large Intestine","Anastomotic Leak Rectum","Intraoperative Awareness"],"enrollment":1600,"completionDate":"2023-12-01"},{"nctId":"NCT00000929","phase":"PHASE1","title":"A Study of the Effects of Advantage 24 on the Rectum","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":["HIV Infections"],"enrollment":70,"completionDate":"1999-07"},{"nctId":"NCT00000926","phase":"PHASE3","title":"A Study of Nonoxynol-9 (N-9) and HIV Infection","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":["HIV Infections"],"enrollment":4400,"completionDate":"2001-02"},{"nctId":"NCT01262053","phase":"NA","title":"Investigating Wrong-Patient Computerized Physician Order Entry (CPOE) Errors","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2010-12","conditions":["Wrong Patient Computerized Physician Order Entry Errors"],"enrollment":4028,"completionDate":"2011-06"},{"nctId":"NCT00274261","phase":"PHASE3","title":"Study of the Safety and Contraceptive Efficacy of C31G Compared to Conceptrol®","status":"COMPLETED","sponsor":"Premier Research","startDate":"2004-06","conditions":["Pregnancy"],"enrollment":1565,"completionDate":"2008-09"},{"nctId":"NCT00578877","phase":"PHASE2,PHASE3","title":"Contraceptive Effectiveness and Safety of the SILCS 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Gel","status":"COMPLETED","sponsor":"CONRAD","startDate":"2014-12","conditions":["Contraception"],"enrollment":27,"completionDate":"2016-03"},{"nctId":"NCT02168452","phase":"","title":"Clinical Application of Dual Sentinel Lymph Node Staining Method in Breast Cancer","status":"COMPLETED","sponsor":"National Cancer Center, Korea","startDate":"2014-06","conditions":["Breast Cancer"],"enrollment":5,"completionDate":"2015-01"},{"nctId":"NCT01200303","phase":"PHASE2,PHASE3","title":"Evaluation of Computer-assisted, Non-cathartic CT Colonography","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2005-06","conditions":["Colonic Polyps"],"enrollment":605,"completionDate":"2011-01"},{"nctId":"NCT00389311","phase":"EARLY_PHASE1","title":"A Pilot Study for Toxicity Evaluation of HIV Rectal Microbicides","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2007-04","conditions":["HIV 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Device"],"enrollment":40,"completionDate":"2004-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Vaginal","formulation":"Aerosol, Film, Gel, Sponge","formulations":[{"form":"AEROSOL, FOAM","route":"VAGINAL","productName":"VCF CONTRACEPTIVE"},{"form":"FILM, SOLUBLE","route":"VAGINAL","productName":"VCF CONTRACEPTIVE"},{"form":"GEL","route":"VAGINAL","productName":"ConceptrolOptions"},{"form":"GEL","route":"VAGINAL","productName":"Gynol IIExtra Strength"},{"form":"GEL, METERED","route":"VAGINAL","productName":"VCF CONTRACEPTIVE PRE-FILLED APPLICATORS"},{"form":"SPONGE","route":"VAGINAL","productName":"Today Vaginal Contraceptive"}]},"crossReferences":{"MMSL":"5185","NDDF":"001328","UNII":"48Q180SH9T","CHEBI":"CHEBI:53775","VANDF":"4018924","RXNORM":"53750","UMLSCUI":"C0068943","chemblId":"CHEMBL2108472","ChEMBL_ID":"CHEMBL2108472","DRUGBANK_ID":"DB06804","PUBCHEM_CID":"7700","SNOMEDCT_US":"326454008","MESH_DESCRIPTOR_UI":"D017137"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"1963-","companyName":"Personal Prods","relationship":"Original Developer"}],"publicationCount":17,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"originalDeveloper":"Personal Prods","recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"Personal Prods","companyId":"personal-prods","modality":"Small Molecule","firstApprovalDate":"1963","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":"1963-12-10T00:00:00.000Z","mah":"PERSONAL 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