{"id":"non-tnfi-biologic-class","_chembl":{"chemblId":"CHEMBL450072","moleculeType":"Small molecule","molecularWeight":"140.23"},"_dailymed":null,"_scrapedAt":"2026-03-28T01:23:17.195Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779122719,"model":"claude-sonnet-4-5-20250929"},"description":"Non-TNFi biologics represent a class of targeted immunomodulatory therapies that work through mechanisms distinct from tumor necrosis factor inhibition. These agents are being investigated at the University of Alabama at Birmingham in phase 3 trials for immune-mediated conditions.","indications":{"approved":[{"status":"investigational","condition":null,"patientPopulation":null}]},"trialDetails":[{"nctId":"NCT04692493","phase":"PHASE3","title":"RA-PRO PRAGMATIC TRIAL","status":"RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2021-09-22","conditions":"Rheumatoid Arthritis","enrollment":924}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"non-TNFi-biologic class","genericName":"non-TNFi-biologic class","companyName":"University of Alabama at Birmingham","companyId":"university-of-alabama-at-birmingham","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Non-TNFi-biologic class refers to a type of medication used to treat Rheumatoid Arthritis, which is a targeted synthetic DMARD. This class of medication is being studied in real-world settings, such as in the RA-PRO PRAGMATIC TRIAL, to evaluate its effectiveness in treating the condition.","enrichmentLevel":2,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}