{"id":"non-ras-inhibitor-antihypertensive-therapy","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Non-RAS inhibitors are a class of antihypertensive drugs that target various pathways to lower blood pressure. They do not inhibit the renin-angiotensin-aldosterone system (RAS), which is targeted by other antihypertensive drugs. Instead, they work through different mechanisms to relax blood vessels and improve blood flow.","oneSentence":"Non-RAS inhibitor antihypertensive therapy works by blocking the action of certain natural chemicals in the body that cause blood vessels to constrict, leading to a decrease in blood pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:23:18.166Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT00985322","phase":"PHASE3","title":"Angiotensin-converting-enzyme (ACE) Inhibitors in Hemodialysis","status":"COMPLETED","sponsor":"Mario Negri Institute for Pharmacological Research","startDate":"2009-05","conditions":"Left Ventricular Hypertrophy, Hypertension","enrollment":269}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"non-RAS inhibitor antihypertensive therapy","genericName":"non-RAS inhibitor antihypertensive therapy","companyName":"Mario Negri Institute for Pharmacological Research","companyId":"mario-negri-institute-for-pharmacological-research","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Non-RAS inhibitor antihypertensive therapy works by blocking the action of certain natural chemicals in the body that cause blood vessels to constrict, leading to a decrease in blood pressure. Used for Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}