{"id":"non-ppi-gefarnate","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gefarnate works by stimulating mucus secretion and promoting the healing of gastric mucosa through cytoprotective mechanisms. Unlike proton pump inhibitors that reduce acid production, gefarnate maintains normal acid levels while fortifying the stomach's natural protective mechanisms, making it suitable for patients who cannot tolerate or require alternatives to PPIs.","oneSentence":"Gefarnate is a mucoprotective agent that enhances gastric mucus production and strengthens the gastric mucosal barrier to protect against acid-induced damage.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:23:20.157Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastric ulcer"},{"name":"Duodenal ulcer"},{"name":"Gastritis"}]},"trialDetails":[{"nctId":"NCT01051388","phase":"PHASE3","title":"Cardio-cerebrovascular Disease and Aspirin Ulcer Relapse Evaluation","status":"COMPLETED","sponsor":"Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan","startDate":"2008-08","conditions":"Cardio-cerebrovascular Disease","enrollment":280}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Non-PPI (Gefarnate)","genericName":"Non-PPI (Gefarnate)","companyName":"Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan","companyId":"translational-research-center-for-medical-innovation-kobe-hyogo-japan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gefarnate is a small molecule non-proton pump inhibitor (Non-PPI) used in research. It has been studied in clinical trials for the treatment of cardio-cerebrovascular disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}