{"id":"non-opioid-analgesics","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Hepatotoxicity (acetaminophen)"},{"rate":null,"effect":"Renal impairment (NSAIDs)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This class encompasses multiple mechanisms including COX inhibition (NSAIDs), acetaminophen's central nervous system effects, and other non-opioid pain pathways. They work to reduce inflammation, block pain signal transmission, or modulate pain perception through non-opioid mechanisms, making them suitable alternatives or adjuncts to opioid therapy.","oneSentence":"Non-opioid analgesics reduce pain by inhibiting cyclooxygenase enzymes or other pain signaling pathways without activating opioid receptors.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:23:18.174Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management"},{"name":"Chronic pain conditions"},{"name":"Post-operative pain"}]},"trialDetails":[{"nctId":"NCT04751175","phase":"PHASE4","title":"Management of Pain in Lumbar Arthrodesis","status":"COMPLETED","sponsor":"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","startDate":"2013-07-04","conditions":"Pain, Postoperative","enrollment":128},{"nctId":"NCT06706375","phase":"NA","title":"Compared Reversed US-Guided Dorsal Penile Nerve Block (RUSDPNB) With DPNB in Circumcisions for Pediatric Patients","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire Vaudois","startDate":"2024-11-29","conditions":"Circumcision, Ultrasound, Opioid Consumption","enrollment":216},{"nctId":"NCT06663345","phase":"NA","title":"Effects of TAP and QLB-1 Blocks on Opioid Consumption","status":"COMPLETED","sponsor":"Başakşehir Çam & Sakura City Hospital","startDate":"2025-01-02","conditions":"Postoperative Pain","enrollment":65},{"nctId":"NCT07489001","phase":"","title":"Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-12-09","conditions":"Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis","enrollment":75},{"nctId":"NCT07122453","phase":"PHASE1","title":"Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain","status":"RECRUITING","sponsor":"Centrexion Therapeutics","startDate":"2026-03","conditions":"Lower Back Pain","enrollment":16},{"nctId":"NCT05480228","phase":"PHASE2","title":"EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA","status":"COMPLETED","sponsor":"James P. Rathmell, MD","startDate":"2022-09-21","conditions":"Painful Diabetic Neuropathy","enrollment":127},{"nctId":"NCT03818932","phase":"PHASE2, PHASE3","title":"Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2019-01-22","conditions":"Anterior Cruciate Ligament Injury","enrollment":90},{"nctId":"NCT07307170","phase":"NA","title":"The Analgesic Efficacy and Safety of Mirogabalin in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Mirogabalin, Pain","enrollment":750},{"nctId":"NCT06978816","phase":"NA","title":"Ear Pressure Points Plus Pain Meds for Faster Kidney Stone Pain Relief","status":"RECRUITING","sponsor":"Gao Xiaofeng","startDate":"2025-06-01","conditions":"Renal Colic, Acupuncture, Ear","enrollment":116},{"nctId":"NCT07264270","phase":"PHASE1","title":"Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy","status":"RECRUITING","sponsor":"Consano Bio","startDate":"2025-12-03","conditions":"Lumbosacral Radicular Pain, Sciatic Radiculopathy, Sciatic Leg Pain","enrollment":24},{"nctId":"NCT06885086","phase":"","title":"ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cukurova University","startDate":"2025-06-13","conditions":"Laparoscopic Cholecystectomy","enrollment":120},{"nctId":"NCT06365892","phase":"NA","title":"Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2024-07-01","conditions":"Adolescent Idiopathic Scoliosis (AIS)","enrollment":64},{"nctId":"NCT07197567","phase":"","title":"Equivalent MAC in General Anesthesia","status":"COMPLETED","sponsor":"Sakarya University","startDate":"2025-11-01","conditions":"General Anesthesia, Intraoperative Monitoring, Anesthetic Depth","enrollment":60},{"nctId":"NCT07461506","phase":"NA","title":"NeuroCuple to Mitigate Post-Wisdom Teeth Extraction Opioid Risks","status":"NOT_YET_RECRUITING","sponsor":"nCap Medical","startDate":"2026-06-30","conditions":"Wisdom Teeth, Wisdom Teeth Extraction or Jaw Implant","enrollment":120},{"nctId":"NCT04495725","phase":"NA","title":"Do Discounted Vouchers for Medical Cannabis Reduce Opioid Use in Adults With Pain","status":"COMPLETED","sponsor":"Vireo Health","startDate":"2020-10-06","conditions":"Opioid Use, Marijuana, Chronic Pain","enrollment":270},{"nctId":"NCT07154433","phase":"NA","title":"A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2025-09-01","conditions":"Ankle (Ligaments); Instability (Old Injury), Ankle Sprain, Talus Osteochondral Defect","enrollment":110},{"nctId":"NCT05929937","phase":"PHASE4","title":"No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair","status":"ACTIVE_NOT_RECRUITING","sponsor":"Clayton Petro","startDate":"2023-07-10","conditions":"Postoperative Pain, Inguinal Hernia","enrollment":904},{"nctId":"NCT07453628","phase":"","title":"Association of Erectile Dysfunction With Neuropathic Pain, Disease Activity, and Functional Status in Male Patients With Axial Spondyloarthritis: A Cross-Sectional Observational Study","status":"COMPLETED","sponsor":"Altuğ Güner","startDate":"2021-02-03","conditions":"Ankylosing Spondylitis, Sexual Dysfunction","enrollment":90},{"nctId":"NCT06671002","phase":"PHASE4","title":"Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial","status":"RECRUITING","sponsor":"University of Michigan","startDate":"2025-01-10","conditions":"Surgery, Pain, Post Operative","enrollment":900},{"nctId":"NCT06962085","phase":"NA","title":"Sacral Erector Spinae Plane Block in Transurethral Prostate Resection Surgery","status":"COMPLETED","sponsor":"Adiyaman University","startDate":"2025-09-05","conditions":"TURP(Transurethral Resection of Prostate)","enrollment":60},{"nctId":"NCT03718039","phase":"PHASE2","title":"Phase 2 Bunionectomy HTX-011 Administration Study","status":"COMPLETED","sponsor":"Heron Therapeutics","startDate":"2018-10-24","conditions":"Postoperative Pain","enrollment":78},{"nctId":"NCT03695367","phase":"PHASE2","title":"Phase 2 Herniorrhaphy Study for Opioid Elimination","status":"COMPLETED","sponsor":"Heron Therapeutics","startDate":"2018-10-01","conditions":"Postoperative Pain","enrollment":63},{"nctId":"NCT03974932","phase":"PHASE3","title":"Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen","status":"COMPLETED","sponsor":"Heron Therapeutics","startDate":"2019-06-05","conditions":"Analgesia","enrollment":116},{"nctId":"NCT07433803","phase":"NA","title":"Comparison of the Postoperative Analgesic Efficacy of Infiltration Between the Popliteal Artery and the Capsule of the Knee (iPACK) Block and the Biceps Femoris Short Head Plane (BiFeS) Block in Total Knee Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Soma State Hospital","startDate":"2026-03-15","conditions":"Postoperative Pain","enrollment":100},{"nctId":"NCT07431905","phase":"NA","title":"Effect of Erector Spinae Plane Block on Postoperative Analgesia and Stress Response in Laparoscopic Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Harran University","startDate":"2023-02-05","conditions":"Bariatric Sleeve Gastrectomy, Erector Spina Plan Block, Cortisol","enrollment":60},{"nctId":"NCT05051735","phase":"PHASE3","title":"PARASTOP - Paracetamol With Strong Opioids","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2021-10-20","conditions":"Cancer Pain, Cancer","enrollment":204},{"nctId":"NCT06201676","phase":"PHASE4","title":"Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-02-28","conditions":"Orthopaedic Trauma, Chronic Opioid Use","enrollment":458},{"nctId":"NCT07166991","phase":"PHASE3","title":"Anesthesia sTrategy foR Organ Procurement In braiN dEath","status":"RECRUITING","sponsor":"University Hospital, Grenoble","startDate":"2026-02-17","conditions":"Brain-dead Organ Donors","enrollment":270},{"nctId":"NCT07192770","phase":"","title":"G-CSF-Induced Bone Pain and Supportive Care Approaches","status":"COMPLETED","sponsor":"Ankara Etlik City Hospital","startDate":"2025-09-27","conditions":"Solid Tumors, Chemotherapy-induced Neutropenia","enrollment":225},{"nctId":"NCT06234631","phase":"PHASE2","title":"Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty","status":"RECRUITING","sponsor":"Chad Brummett","startDate":"2024-03-13","conditions":"Knee Replacement Surgery, Osteoarthritis, Knee","enrollment":380},{"nctId":"NCT07413731","phase":"","title":"Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation","status":"RECRUITING","sponsor":"Brai²n","startDate":"2025-02-03","conditions":"Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), Lower Spine, Spinal Cord Sensitivity to Neurostimulation, Neurophysiological Sensitivity to Spinal Cord Stimulation","enrollment":50},{"nctId":"NCT07395999","phase":"","title":"Effectiveness of Pain Management Interventions in Patients With Chronic Cancer Pain","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2025-11-14","conditions":"Chronic Cancer Pain, Pain Management","enrollment":134},{"nctId":"NCT07404124","phase":"NA","title":"Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients","status":"NOT_YET_RECRUITING","sponsor":"Fatih Sultan Mehmet Training and Research Hospital","startDate":"2026-03-01","conditions":"Diabetes Mellitus, Diabetic Neuropathy, Postoperative Pain Management","enrollment":46},{"nctId":"NCT05640674","phase":"PHASE4","title":"Post-operative Pain Management in Children With Supracondylar Humerus Fractures","status":"TERMINATED","sponsor":"Baylor College of Medicine","startDate":"2023-09-12","conditions":"Supracondylar Humerus Fracture","enrollment":29},{"nctId":"NCT05488847","phase":"PHASE4","title":"Opioid-Free Pain Protocol After Shoulder Arthroplasty","status":"ACTIVE_NOT_RECRUITING","sponsor":"Henry Ford Health System","startDate":"2022-06-25","conditions":"Shoulder Arthropathy, Shoulder Pain","enrollment":83},{"nctId":"NCT06626503","phase":"PHASE3","title":"Evaluation of Analgesia for Spine Fusion Elective Surgery in Children","status":"RECRUITING","sponsor":"Senthil Sadhasivam","startDate":"2025-10-30","conditions":"Idiopathic Scoliosis","enrollment":500},{"nctId":"NCT07226700","phase":"PHASE3","title":"Suzetrigine in Total Hip Arthroplasty","status":"RECRUITING","sponsor":"Hospital for Special Surgery, New York","startDate":"2025-11-03","conditions":"Total Hip Arthroplasty (THA), Total Hip Arthroplasty \\(THA\\), Total Hip Replacement","enrollment":210},{"nctId":"NCT07368413","phase":"NA","title":"Comparison of the Analgesic Efficacy of Erector Spinae Plane Block in Breast-Conserving Surgery Versus Serratus Anterior Block Combined With Additional Pecto-Intercostal II Block","status":"NOT_YET_RECRUITING","sponsor":"Kayseri City Hospital","startDate":"2026-02-10","conditions":"Pain Management in Breast Surgery, Pain After Surgery, Regional Anaesthesia","enrollment":70},{"nctId":"NCT06835335","phase":"","title":"Opioid Prescribing in the Emergency Department for Sickle Cell Disease","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2025-02-17","conditions":"Discrimination, Racial, Pain Management, Emergency Medicine","enrollment":1063},{"nctId":"NCT07357376","phase":"PHASE3","title":"Evaluating Suzetrigine for Pain Control Following TKA","status":"NOT_YET_RECRUITING","sponsor":"AdventHealth","startDate":"2026-03-01","conditions":"Postoperative Pain Following Knee Arthroplasty","enrollment":210},{"nctId":"NCT07265557","phase":"NA","title":"Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-10-06","conditions":"Orthopaedic Related Pain (Musculoskeletal Pain), Opioid, Pain","enrollment":100},{"nctId":"NCT07352982","phase":"NA","title":"Transcutaneous Tibial Nerve Stimulation on Women With Primary Dysmenorrhea","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2026-01-19","conditions":"Transcutaneous Tibial Nerve Stimulation, Women, Primary Dysmenorrhea","enrollment":32},{"nctId":"NCT07351994","phase":"","title":"Autonomic Neural Field Block for Visceral Pain in Minimally Invasive Left-Sided Colectomy","status":"NOT_YET_RECRUITING","sponsor":"Antonio Caycedo, MD","startDate":"2026-01-20","conditions":"Postoperative Pain, Postoperative Nausea, Opioid Use","enrollment":400},{"nctId":"NCT07353372","phase":"NA","title":"Multimodal Exercise Therapy for Non-Surgical Intervention of Nonspecific Low Back Pain.","status":"NOT_YET_RECRUITING","sponsor":"Xuanwu Hospital, Beijing","startDate":"2026-01-01","conditions":"Paraspinal Muscles, Low Back Pain, Machine Learning","enrollment":314},{"nctId":"NCT07347496","phase":"PHASE4","title":"A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital of Xinxiang Medical College","startDate":"2026-03-01","conditions":"Thoracic Surgery, Anesthesia, Non-intubated Anesthesia","enrollment":50},{"nctId":"NCT07348627","phase":"PHASE3","title":"Opioid-Sparing Joint Replacement","status":"NOT_YET_RECRUITING","sponsor":"Emory University","startDate":"2026-02","conditions":"Pain Management, Opioid Consumption","enrollment":120},{"nctId":"NCT06187584","phase":"PHASE4","title":"SCHF Post-Op Study Between Opioid and Non-Opioid Pain Management","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's Mercy Hospital Kansas City","startDate":"2019-04-15","conditions":"Supracondylar Humerus Fracture","enrollment":160},{"nctId":"NCT06309693","phase":"NA","title":"Postoperative Pain Management Following Robotic Assisted Sacrocolpopexy","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2025-01-22","conditions":"Pelvic Organ Prolapse, Post Operative Pain","enrollment":70},{"nctId":"NCT07331441","phase":"NA","title":"External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abdominal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Jun Zhang","startDate":"2026-01-15","conditions":"Abdominal Surgery, Postoperative Pain","enrollment":78},{"nctId":"NCT07327138","phase":"NA","title":"Children's Laughter and Fun Yoga as Adjunctive Pain Relief Following Chemotherapy.","status":"RECRUITING","sponsor":"Bahaa Bou Dargham","startDate":"2025-10-15","conditions":"Acute Lymphoblastic Leukemia ALL","enrollment":60},{"nctId":"NCT04291599","phase":"PHASE2","title":"Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid","status":"TERMINATED","sponsor":"Boston Children's Hospital","startDate":"2022-03-15","conditions":"Acute Pancreatitis","enrollment":23},{"nctId":"NCT06160947","phase":"NA","title":"The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study","status":"NOT_YET_RECRUITING","sponsor":"McMaster University","startDate":"2026-04-01","conditions":"Back Pain","enrollment":24},{"nctId":"NCT07323914","phase":"PHASE3","title":"Clinical Analgesic Management in Dementia","status":"RECRUITING","sponsor":"Xuanwu Hospital, Beijing","startDate":"2025-03-01","conditions":"Alzheimer Disease","enrollment":10},{"nctId":"NCT05864053","phase":"PHASE1, PHASE2","title":"(2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic Pain","status":"RECRUITING","sponsor":"Rush University Medical Center","startDate":"2024-09-19","conditions":"Pain, Neuropathic","enrollment":25},{"nctId":"NCT07310524","phase":"NA","title":"COMPARISON OF OPIOID-FREE AND OPIOID-BASED ANESTHESIA TECHNIQUES ON qNOX INDEX IN ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA","status":"COMPLETED","sponsor":"Muhammad Rahman Efendi Nasution","startDate":"2025-09-08","conditions":"Opioid-free Anesthesia","enrollment":42},{"nctId":"NCT07296770","phase":"PHASE3","title":"An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service","status":"NOT_YET_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2026-05-01","conditions":"Postsurgical Pain Management, Postsurgical Pain, Chronic, Opioid Use After Surgery","enrollment":126},{"nctId":"NCT07276126","phase":"NA","title":"The Effect of the Cesarean ERAS Protocol on Mother-Infant and Father-Infant Bonding: a Multicenter, Randomized Controlled Clinical Trial.","status":"RECRUITING","sponsor":"Okan University","startDate":"2025-12-13","conditions":"Bonding, ERAS, Cesarean Section","enrollment":1},{"nctId":"NCT04236908","phase":"NA","title":"Accessible Acupuncture for the Warrior With Acute Low Back Pain","status":"COMPLETED","sponsor":"David Moss","startDate":"2020-08-25","conditions":"Acupuncture, Low Back Pain","enrollment":276},{"nctId":"NCT04452344","phase":"PHASE3","title":"Opioid Analgesic Reduction Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Rutgers, The State University of New Jersey","startDate":"2021-01-04","conditions":"Opioid Use","enrollment":1815},{"nctId":"NCT06271668","phase":"","title":"Clinical Decision Support to Improve System Naloxone Co-prescribing","status":"ENROLLING_BY_INVITATION","sponsor":"University of Colorado, Denver","startDate":"2024-07-01","conditions":"Medication Abuse, Harm Reduction, Opioid Overdose","enrollment":200000},{"nctId":"NCT05252754","phase":"PHASE3","title":"Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2023-01-18","conditions":"Post-ERCP Acute Pancreatitis","enrollment":4874},{"nctId":"NCT07271654","phase":"NA","title":"Can Pretreatment With Analgesics Reduce Postendodontic Pain?","status":"COMPLETED","sponsor":"College of Physicians and Surgeons Pakistan","startDate":"2025-08-01","conditions":"Pulpitis - Irreversible","enrollment":160},{"nctId":"NCT07246694","phase":"NA","title":"Enhanced Recovery After Uvulopalatoplasty","status":"NOT_YET_RECRUITING","sponsor":"Zagazig University","startDate":"2025-12","conditions":"Analgesia, Recovery, Psychological","enrollment":80},{"nctId":"NCT07117318","phase":"NA","title":"Rectal NSAIDs With/Without PD Stent for PEP Prevention","status":"RECRUITING","sponsor":"Air Force Military Medical University, China","startDate":"2025-07-01","conditions":"Post-ERCP Acute Pancreatitis, Non-steroid Anti-inflammatory Drugs, Pancreatic Duct Stent Placement","enrollment":1278},{"nctId":"NCT03584152","phase":"PHASE2","title":"Postoperative Pain Management in Rhinoplasty","status":"COMPLETED","sponsor":"Stanford University","startDate":"2019-08-09","conditions":"Pain, Postoperative","enrollment":159},{"nctId":"NCT07254936","phase":"NA","title":"Comparison of Pain Using CPOT Score With Ketamine vs. Dexmedetomidine in Post-Craniotomy ICU Patients","status":"COMPLETED","sponsor":"Universitas Sumatera Utara","startDate":"2025-03-01","conditions":"Post-craniotomy Pain Management, Post-craniotomy, Pain Control in ICU","enrollment":38},{"nctId":"NCT06113211","phase":"PHASE4","title":"Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures","status":"RECRUITING","sponsor":"Henry Ford Health System","startDate":"2024-10-01","conditions":"Opioid Use, Fractures, Bone, Trauma","enrollment":75},{"nctId":"NCT07077200","phase":"","title":"Comparison of Intranasal Dexmedetomidine and Short Video Viewing in the Preoperative Anxiety","status":"COMPLETED","sponsor":"Samsun University","startDate":"2025-07-01","conditions":"Anesthesia, Sedation, Anxiety","enrollment":50},{"nctId":"NCT04300751","phase":"PHASE1","title":"The Behavioral Effects of Opioids and Alcohol","status":"COMPLETED","sponsor":"Sharon Walsh","startDate":"2021-03-24","conditions":"Opioid Use, Alcohol Drinking","enrollment":11},{"nctId":"NCT07238582","phase":"NA","title":"Effectiveness of an Innovative Chest Stabilizer in Rib Fracture Treatment: Impact on Respiratory Function, Complications, and Clinical Outcomes","status":"NOT_YET_RECRUITING","sponsor":"Caner İşevi, MD","startDate":"2025-12-01","conditions":"Rib Fractures, Blunt Chest Trauma, Thoracic Injuries","enrollment":74},{"nctId":"NCT06860984","phase":"PHASE3","title":"Evaluating the Safety and Efficacy of Duloxetine in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis","status":"RECRUITING","sponsor":"Tanta University","startDate":"2025-03-10","conditions":"Biliary Disease","enrollment":44},{"nctId":"NCT07229495","phase":"PHASE4","title":"Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery","status":"NOT_YET_RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2026-01-01","conditions":"Scoliosis; Adolescence, Pain After Surgery, Analgesia, Patient-controlled","enrollment":171},{"nctId":"NCT07043452","phase":"EARLY_PHASE1","title":"Measuring Acute Drug Demand in Humans II","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2025-11-15","conditions":"Healthy Volunteers","enrollment":""},{"nctId":"NCT06571110","phase":"NA","title":"Analgesic Response to Opioids in Patients With Fibromyalgia After Conventional Acupuncture Versus Sham Acupuncture","status":"RECRUITING","sponsor":"University of California, Irvine","startDate":"2025-03-15","conditions":"Fibromyalgia","enrollment":45},{"nctId":"NCT06574009","phase":"PHASE4","title":"Better Options for Chronic Cancer Pain","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2025-10-07","conditions":"Chronic Pain, Cancer Survivor, Opioid Dependence","enrollment":294},{"nctId":"NCT06940570","phase":"PHASE3","title":"Methadone as an Alternative Treatment for Children Underdoing HSCT","status":"SUSPENDED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2028-01-01","conditions":"Leukemia, Aplastic Anemia, Bone Marrow Failure Syndromes","enrollment":60},{"nctId":"NCT06860711","phase":"PHASE4","title":"Safety of Short-course of NSAIDs in Pediatric Patients With CKD","status":"RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2025-07-22","conditions":"Chronic Kidney Disease, Pediatric Urology","enrollment":80},{"nctId":"NCT05444361","phase":"NA","title":"Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Postoperative Pain After Mastectomy","status":"ENROLLING_BY_INVITATION","sponsor":"University of California, San Diego","startDate":"2022-09-15","conditions":"Mastectomy; Lymphedema","enrollment":216},{"nctId":"NCT06069154","phase":"NA","title":"Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma","status":"ENROLLING_BY_INVITATION","sponsor":"University of California, San Diego","startDate":"2023-10-30","conditions":"Rib Fracture, Rib Fracture Multiple","enrollment":120},{"nctId":"NCT04315181","phase":"PHASE1","title":"Prescription Medication Interactions","status":"COMPLETED","sponsor":"Sharon Walsh","startDate":"2019-03-25","conditions":"Opioid Use, Sedative Use","enrollment":11},{"nctId":"NCT04459416","phase":"PHASE3","title":"Managing Pain and Symptom Burden Caused by Chemotherapy in People With Myeloma or Lymphoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2020-06-30","conditions":"Multiple Myeloma, Hodgkin Disease, Non-Hodgkin Lymphoma","enrollment":299},{"nctId":"NCT05722002","phase":"PHASE4","title":"Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial","status":"RECRUITING","sponsor":"University of Michigan","startDate":"2023-02-06","conditions":"Surgery, Pain, Postoperative","enrollment":900},{"nctId":"NCT04921449","phase":"NA","title":"ED Physical Therapy for Acute Low Back Pain","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2021-07-12","conditions":"Low Back Pain","enrollment":360},{"nctId":"NCT05206630","phase":"NA","title":"ED Physical Therapy for Chronic Low Back Pain","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2022-01-11","conditions":"Low Back Pain","enrollment":128},{"nctId":"NCT04395001","phase":"PHASE4","title":"Pain Response Evaluation of a Combined Intervention to Cope Effectively","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2021-02-24","conditions":"Chronic Pain","enrollment":280},{"nctId":"NCT07211529","phase":"NA","title":"Intraoperative Paravertebral Block and Postoperative Complications","status":"RECRUITING","sponsor":"Tongji Hospital","startDate":"2025-03-25","conditions":"Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis), Pulmonary Infections","enrollment":500},{"nctId":"NCT05642026","phase":"PHASE4","title":"INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures","status":"RECRUITING","sponsor":"Zachary Warriner","startDate":"2025-09-23","conditions":"Rib Fractures","enrollment":180},{"nctId":"NCT07207304","phase":"NA","title":"Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes","status":"COMPLETED","sponsor":"Iuliu Hatieganu University of Medicine and Pharmacy","startDate":"2022-02-03","conditions":"Hepato-cellular Carcinoma, Neutrophil Extracellular Trap Formation, Anesthesia","enrollment":153},{"nctId":"NCT07195669","phase":"PHASE4","title":"RCT: Suzetrigine vs Norco for Post-op Pain","status":"NOT_YET_RECRUITING","sponsor":"Jacob Lensing","startDate":"2025-10-01","conditions":"Pain Control","enrollment":76},{"nctId":"NCT05171179","phase":"PHASE3","title":"The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2021-10-22","conditions":"Mammaplasty","enrollment":60},{"nctId":"NCT06798714","phase":"PHASE4","title":"The Effect of Colchicine on the Occurrence of Atrial Fibrillation After Cardiac Surgery","status":"RECRUITING","sponsor":"Tomsk Cardiology Research Institute","startDate":"2025-01-20","conditions":"Coronary Artery Disease, Atrial Fibrillation, Coronary Artery Bypass Grafting","enrollment":140},{"nctId":"NCT06519929","phase":"PHASE4","title":"Analgesic Techniques for Rib Fractures","status":"ACTIVE_NOT_RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2024-09-23","conditions":"Rib Fractures","enrollment":24},{"nctId":"NCT07102641","phase":"PHASE4","title":"Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies","status":"RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2025-08-26","conditions":"Cesarean Delivery, Postpartum Comfort, Postpartum Pain","enrollment":825},{"nctId":"NCT01106716","phase":"PHASE2","title":"Safety and Efficacy Study of KAI-1678 to Treat Pain in Subjects With Postherpetic Neuralgia","status":"COMPLETED","sponsor":"KAI Pharmaceuticals","startDate":"2009-03","conditions":"Postherpetic Neuralgia","enrollment":23},{"nctId":"NCT01135108","phase":"PHASE2","title":"Safety and Efficacy Study of KAI-1678 to Treat Pain in Subjects With Spinal Cord Injury","status":"COMPLETED","sponsor":"KAI Pharmaceuticals","startDate":"2009-03","conditions":"Spinal Cord Injury","enrollment":5},{"nctId":"NCT07139691","phase":"NA","title":"TAP Block With Lidocaine and Ropivacaine 0.2% (0.4 ml/kg/Side) for Pain and Opioid Reduction After Hysterectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Matild Keresztes","startDate":"2024-01-12","conditions":"Postoperative Pain Following Hysterectomy","enrollment":82},{"nctId":"NCT05231460","phase":"PHASE4","title":"Pain Management Study","status":"ENROLLING_BY_INVITATION","sponsor":"University of Arizona","startDate":"2022-02-18","conditions":"Pain, Postoperative","enrollment":244},{"nctId":"NCT07127107","phase":"NA","title":"Effect of Manual Therapy on Migraine in Postmenopausal Women","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-08-20","conditions":"Migraine","enrollment":40},{"nctId":"NCT05708521","phase":"PHASE4","title":"Personalization of Opioid Prescription Following Orthognathic Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Nova Scotia Health Authority","startDate":"2023-04-24","conditions":"Pain, Postoperative, Orthognathic Surgery, Opioid Use","enrollment":201},{"nctId":"NCT06556121","phase":"NA","title":"Saddle Block With IT Morphine for Penile Inversion Vaginoplasty","status":"RECRUITING","sponsor":"Women's College Hospital","startDate":"2025-08-07","conditions":"Pain, Postoperative","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":824,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Opioid-free regimen","Opioid-free anesthetic"],"phase":"phase_3","status":"active","brandName":"Non Opioid Analgesics","genericName":"Non Opioid Analgesics","companyName":"Muhammad Rahman Efendi Nasution","companyId":"muhammad-rahman-efendi-nasution","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Non-opioid analgesics reduce pain by inhibiting cyclooxygenase enzymes or other pain signaling pathways without activating opioid receptors. Used for Acute pain management, Chronic pain conditions, Post-operative pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}