{"id":"non-ionic-contrast-media-comparator","safety":{"commonSideEffects":[{"rate":"1-5","effect":"Contrast-induced nephropathy"},{"rate":"0.1-1","effect":"Allergic reactions"},{"rate":"1-3","effect":"Nausea and vomiting"},{"rate":"1-2","effect":"Headache"},{"rate":"1-2","effect":"Flushing"}]},"_chembl":{"chemblId":"CHEMBL3983509","moleculeType":"Small molecule","molecularWeight":"434.92"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Non-ionic contrast agents are iodinated compounds that absorb X-rays more readily than surrounding tissue, creating contrast in radiographic images. Unlike ionic contrast media, they do not dissociate into charged particles in solution, resulting in lower osmolality and reduced physiological stress on the body. This makes them safer for patients with renal impairment or those at risk for contrast-induced nephropathy.","oneSentence":"Non-ionic contrast media enhance the visibility of blood vessels and organs during radiographic imaging by increasing radiodensity without causing significant osmotic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:30.532Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contrast enhancement in radiographic imaging procedures including angiography, CT imaging, and urography"}]},"trialDetails":[{"nctId":"NCT01136876","phase":"PHASE4","title":"Kidney Damage in Patients With Moderate Fall in eGFR","status":"COMPLETED","sponsor":"Bracco Diagnostics, Inc","startDate":"2010-11","conditions":"Coronary Artery Stenosis","enrollment":57},{"nctId":"NCT02908035","phase":"PHASE2","title":"Temsirolimus Adventitial Delivery to Improve Angiographic Outcomes Below the Knee (TANGO)","status":"UNKNOWN","sponsor":"Mercator MedSystems, Inc.","startDate":"2017-03-03","conditions":"Chronic Limb Ischemia","enrollment":100},{"nctId":"NCT01137786","phase":"PHASE4","title":"Kidney Damage in Patients With Normal eGFR","status":"COMPLETED","sponsor":"Bracco Diagnostics, Inc","startDate":"2010-12","conditions":"Coronary Artery Stenosis","enrollment":49}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Isovue 370","Visipaque 320"],"phase":"marketed","status":"active","brandName":"Non ionic contrast media comparator","genericName":"Non ionic contrast media comparator","companyName":"Bracco Diagnostics, Inc","companyId":"bracco-diagnostics-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Non-ionic contrast media enhance visualization of internal body structures during medical imaging by increasing radiodensity without causing significant osmotic stress to tissues. Used for Contrast enhancement in computed tomography imaging, Contrast enhancement in angiography and vascular imaging, Contrast enhancement in urography and renal imaging.","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":"1996-03-22T00:00:00.000Z","mah":"GE HEALTHCARE","brand_name_local":"VISIPAQUE 320","application_number":"NDA020351"},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":"1997-08-29T00:00:00.000Z","mah":"GE HEALTHCARE","brand_name_local":"VISIPAQUE 320","application_number":"NDA020808"}],"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}