{"id":"non-effervescent-paracetamol-kern","safety":{"commonSideEffects":[{"rate":null,"effect":"Hepatotoxicity (at overdose)"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL5592090","moleculeType":null,"molecularWeight":"152.15"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Paracetamol (acetaminophen) acts primarily as a weak inhibitor of COX-1 and COX-2 enzymes, with preferential central nervous system penetration. This reduces prostaglandin production in the brain and spinal cord, leading to analgesic and antipyretic effects. The non-effervescent formulation is a solid oral dosage form without carbonation, designed for conventional swallowing.","oneSentence":"Paracetamol inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes in the central nervous system, reducing pain and fever.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:32.640Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever reduction"}]},"trialDetails":[{"nctId":"NCT02514538","phase":"PHASE4","title":"EVALUATION OF THE RELATIONSHIP BETWEEN EFFERVESCENT PARACETAMOL AND BLOOD PRESSURE. CLINICAL TRIAL.","status":"UNKNOWN","sponsor":"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina","startDate":"2012-02","conditions":"Hypertension, Chronic Disease of Musculoskeletal System","enrollment":49}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Non- effervescent Paracetamol kern","genericName":"Non- effervescent Paracetamol kern","companyName":"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina","companyId":"fundacio-d-investigacio-en-atencio-primaria-jordi-gol-i-gurina","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Paracetamol inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes in the central nervous system, reducing pain and fever. Used for Mild to moderate pain, Fever reduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}