{"id":"non-active-drug-cream","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Non-active drug creams serve as inert vehicles in pharmaceutical research, containing no pharmacologically active ingredients. They are used as control arms in clinical studies to establish baseline efficacy and safety profiles, allowing researchers to distinguish true drug effects from placebo responses and vehicle effects.","oneSentence":"A non-active placebo cream formulation used as a control comparator in clinical trials.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:57:30.774Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Clinical trial control/comparator agent"}]},"trialDetails":[{"nctId":"NCT02780128","phase":"PHASE1","title":"Next Generation Personalized Neuroblastoma Therapy","status":"TERMINATED","sponsor":"Yael P Mosse","startDate":"2016-07","conditions":"Neuroblastoma, Cancer","enrollment":66},{"nctId":"NCT05342519","phase":"PHASE2","title":"Daily Topical Rapamycin for Vitiligo","status":"ACTIVE_NOT_RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2022-07-28","conditions":"Vitiligo","enrollment":20},{"nctId":"NCT05566262","phase":"PHASE4","title":"Bodewell Products for the Treatment of Atopic Dermatitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2023-11-01","conditions":"Atopic Dermatitis","enrollment":15},{"nctId":"NCT07079969","phase":"PHASE2","title":"Effects of Photobiomodulation and Topical Diclofenac on Inflammation and Pain in Knee Osteoarthritis (EPIC-KO)","status":"NOT_YET_RECRUITING","sponsor":"University of Florida","startDate":"2026-04","conditions":"Knee Pain Chronic","enrollment":32},{"nctId":"NCT07426120","phase":"PHASE3","title":"Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-III)","status":"RECRUITING","sponsor":"Psoriasis Research Institute of Guangzhou","startDate":"2026-02-01","conditions":"Psoriasis Vulgaris, Topical Administration, Phase III","enrollment":300},{"nctId":"NCT05289804","phase":"PHASE1, PHASE2","title":"Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment","status":"COMPLETED","sponsor":"University of Dublin, Trinity College","startDate":"2022-09-01","conditions":"Mild Cognitive Impairment, Memory Impairment, Memory Disorders in Old Age","enrollment":80},{"nctId":"NCT06768216","phase":"NA","title":"Effect of Indianized Version of Mediterranean Diet vs. Low Fat Diet on Hepatic Steatosis in Overweight Children and Adolescent With MASLD","status":"RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2025-02-15","conditions":"Metabolic Dysfunction-Associated Steatotic Liver Disease","enrollment":134},{"nctId":"NCT04807842","phase":"NA","title":"Multi-Gyn ActiGel Plus for Treatment of Bacterial Vaginosis","status":"RECRUITING","sponsor":"BioClin BV","startDate":"2021-06-11","conditions":"Bacterial Vaginoses","enrollment":200},{"nctId":"NCT07071363","phase":"NA","title":"COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYS","status":"RECRUITING","sponsor":"Laboratoire Dermatologique ACM","startDate":"2025-06-23","conditions":"Healthy, Melasma (Facial Melasma), Epidermal Melasma","enrollment":40},{"nctId":"NCT05575882","phase":"NA","title":"Anti-relapse Efficacy and Tolerance Assessment of a Cosmetic Cream for Very Dry, Irritated to Atopic Sensitive Skin.","status":"RECRUITING","sponsor":"NAOS Argentina S.A.","startDate":"2022-11-03","conditions":"Atopic Dermatitis, Eczema, Atopic","enrollment":100},{"nctId":"NCT05322525","phase":"PHASE4","title":"A Research Study to Evaluate the Safety and Potential Efficacy of ON101 Cream for the Treatment of Venous Leg Ulcers.","status":"TERMINATED","sponsor":"Oneness Biotech Co., Ltd.","startDate":"2021-06-23","conditions":"Venous Leg Ulcers (VLU)","enrollment":9},{"nctId":"NCT06597591","phase":"NA","title":"Virtual Reality Training for Inhibitory Control in Neurocognitive Disorders","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire de Nice","startDate":"2024-11-18","conditions":"Cognitive Disorder","enrollment":48},{"nctId":"NCT06673654","phase":"PHASE1","title":"A Study, Comparing Ruxolitinib Topical Cream 1.5% (Taro Pharmaceuticals U.S.A, Inc.) to OPZELURA (Ruxolitinib) Cream for the Treatment of Mild-to-Moderate Atopic Dermatitis.","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2023-08-11","conditions":"Atopic Dermatitis","enrollment":476},{"nctId":"NCT06499766","phase":"NA","title":"Methodological Study of the Effect of a Lotion Containing Nature Based Microbial Extract on Atopic Skin","status":"COMPLETED","sponsor":"Uute Scientific Oy","startDate":"2022-11-11","conditions":"Atopic Dermatitis","enrollment":12},{"nctId":"NCT06380452","phase":"PHASE3","title":"Therapy for Scabies With Two Differently Concentrated Permethrin Creams","status":"NOT_YET_RECRUITING","sponsor":"Infectopharm Arzneimittel GmbH","startDate":"2024-05","conditions":"Scabies","enrollment":220},{"nctId":"NCT05338463","phase":"PHASE4","title":"Fespixon Cream for the Treatment of Chronic Diabetic Foot Ulcers (TEXAS 1A, 2A) in Dialysis Patients","status":"COMPLETED","sponsor":"Cathay General Hospital","startDate":"2021-12-01","conditions":"Chronic Diabetic Foot Ulcer","enrollment":5},{"nctId":"NCT06274450","phase":"NA","title":"A Clinical Study on the Improvement of Skin and Living Conditions After Drinking Rosa Roxburghii and Pomegranate Drinks","status":"COMPLETED","sponsor":"Botanee Group Co., Ltd.","startDate":"2022-07-06","conditions":"Skin Laxity","enrollment":70},{"nctId":"NCT03597620","phase":"PHASE4","title":"Evaluating the Efficacy and Tolerability of Application of Metaderm Product for the Treatment of Psoriasis","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2018-11-07","conditions":"Psoriasis","enrollment":11},{"nctId":"NCT04484337","phase":"PHASE1","title":"Study to Evaluate Pharmacokinetic (PK), Safety and Tolerability of Cabotegravir (CAB) 400 Milligrams Per Milliliter (mg/mL) Formulation in Healthy Adult Participants","status":"COMPLETED","sponsor":"ViiV Healthcare","startDate":"2020-07-31","conditions":"HIV Infections","enrollment":138},{"nctId":"NCT00988988","phase":"PHASE4","title":"The Effects of Ethyl-Alpha-Guanido-Methyl Ethanoate on Skin Reactions From Glatiramer Acetate Injections","status":"WITHDRAWN","sponsor":"University of Nebraska","startDate":"2010-02","conditions":"Multiple Sclerosis","enrollment":""},{"nctId":"NCT04908215","phase":"PHASE2","title":"INM-755 (Cannabinol) Cream for Treatment of Epidermolysis Bullosa","status":"COMPLETED","sponsor":"InMed Pharmaceuticals Inc.","startDate":"2021-12-28","conditions":"Epidermolysis Bullosa Simplex, Epidermolysis Bullosa, Junctional, Epidermolysis Bullosa Dystrophica","enrollment":19},{"nctId":"NCT05861310","phase":"PHASE1","title":"Effectivity and Safety of Metronidazole 1% Cream in Rosacea Therapy","status":"UNKNOWN","sponsor":"Dr.dr.Irma Bernadette, SpKK (K)","startDate":"2023-05","conditions":"Rosacea","enrollment":48},{"nctId":"NCT03599323","phase":"","title":"Study on the Safety of the Approved Product Empedic L Cream During Its Routine Use (Active Ingredient is Clotrimazole 1%)","status":"COMPLETED","sponsor":"Bayer","startDate":"2018-07-10","conditions":"Vaginal Candida","enrollment":1033},{"nctId":"NCT05002114","phase":"PHASE1","title":"Evaluation of a Specific Transdermal Cannabidiol Product for Chronic Musculoskeletal Joint Pain.","status":"WITHDRAWN","sponsor":"Louisiana State University Health Sciences Center Shreveport","startDate":"2023-01","conditions":"Musculoskeletal Joint Pain","enrollment":""},{"nctId":"NCT03173547","phase":"PHASE2","title":"A Six Week Topical Cream Study for Subjects With Ichthyosis Vulgaris","status":"COMPLETED","sponsor":"Crown Laboratories, Inc.","startDate":"2017-04-25","conditions":"Ichthyosis Vulgaris","enrollment":80},{"nctId":"NCT01268527","phase":"PHASE2","title":"A 12-Day Randomized, Blinded, Vehicle and Active Comparator-Controlled Study to Determine the Efficacy and Safety of Six Concentrations of Topical E6201 Gel in Subjects With Psoriasis Vulgaris","status":"COMPLETED","sponsor":"Eisai Limited","startDate":"2010-03-15","conditions":"Psoriasis Vulgaris","enrollment":30},{"nctId":"NCT03757078","phase":"","title":"Study to Find Out How Symptoms Severity Changes During the Standard Course of Treatment With the Cream Relief Pro and Suppositories Relief Pro (Active Ingredients Are Fluocortolone + Lidocaine) in Patients Suffering From Twisted and Bulging Veins in the Rectal Area (Acute Hemorrhoids)","status":"COMPLETED","sponsor":"Bayer","startDate":"2018-11-30","conditions":"Acute Hemorrhoids","enrollment":1000},{"nctId":"NCT02210689","phase":"PHASE3","title":"A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatment of Bacterial Vaginosis in Non-pregnant Women","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2014-01","conditions":"BACTERIAL VAGINOSIS, Signs and Symptoms to be Evaluated and Recorded Include, Vaginal Discharge Color, Odor, and Consistency","enrollment":604},{"nctId":"NCT03865147","phase":"PHASE2","title":"Single-centre Study to Investigate Safety and Efficacy of Tri-Solfen in Wound Debridement","status":"UNKNOWN","sponsor":"Medical Ethics UK Ltd","startDate":"2019-01-15","conditions":"Wounds Injuries, Anesthesia, Local","enrollment":90},{"nctId":"NCT03626298","phase":"PHASE4","title":"Efficacy and Tolerability of Nicotinamide Plus Cream for Moderate Acne Vulgaris in Indonesia","status":"COMPLETED","sponsor":"Rumah Sakit Pusat Angkatan Darat Gatot Soebroto","startDate":"2016-08-01","conditions":"Acne Vulgaris","enrollment":125},{"nctId":"NCT02937805","phase":"NA","title":"Effects of a Moisturizing Cream on Vaginal and Vulvar Mucous Membranes","status":"COMPLETED","sponsor":"Petra Larmo","startDate":"2016-10","conditions":"Vaginal Dryness, Vaginal Atrophy, Vulvar Dryness","enrollment":225},{"nctId":"NCT02266160","phase":"PHASE4","title":"Treating Tinnitus Using Eutectic Mixture of Local Anesthetics (EMLA) 5% Cream","status":"COMPLETED","sponsor":"HaEmek Medical Center, Israel","startDate":"2014-11","conditions":"Tinnitus","enrollment":142},{"nctId":"NCT02933177","phase":"NA","title":"Effectiveness of Flash Mediation Therapy","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2016-05","conditions":"Dementia","enrollment":241},{"nctId":"NCT01984775","phase":"PHASE1","title":"A Study to Evaluate the Irritation Potential of GSK2894512 Cream on Skin in Healthy Subjects","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2013-10-30","conditions":"Psoriasis","enrollment":52},{"nctId":"NCT00755053","phase":"PHASE3","title":"Comparative Efficacy of Ovule vs Tablet","status":"COMPLETED","sponsor":"Bayer","startDate":"2008-09","conditions":"Clotrimazole, Ovulen, Vulvovaginal Candidiasis","enrollment":466},{"nctId":"NCT00822133","phase":"PHASE4","title":"Percutaneous Ketamine Versus Lidocaine or Placebo, for Post-Surgery Analgesia, in Patients Undergoing Laparoscopic Partial Lung Resection","status":"UNKNOWN","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2009-02","conditions":"Postoperative Pain","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"non-active drug cream","genericName":"non-active drug cream","companyName":"Tel-Aviv Sourasky Medical Center","companyId":"tel-aviv-sourasky-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A non-active placebo cream formulation used as a control comparator in clinical trials. Used for Clinical trial control/comparator agent.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}