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Nomegestrol is a key that fits into a specific lock, the progesterone receptor, and turns it on or off to affect various bodily functions. This can help regulate menstrual cycles, pregnancy, and other hormone-sensitive processes.","oneSentence":"Nomegestrol is a progestin receptor modulator that works by binding to and activating the progesterone receptor, influencing hormone-sensitive processes.","technicalDetail":"Nomegestrol acts as a selective progesterone receptor modulator (SPRM), binding to the progesterone receptor and influencing gene expression to exert its 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J. Obstet. Gynecol. Reprod. Biol. 299 (2024) 213-218].","journal":"European journal of obstetrics, gynecology, and reproductive biology"},{"date":"2026 Feb","pmid":"41732194","title":"Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysis.","journal":"EClinicalMedicine"},{"date":"2026 Jan","pmid":"41624234","title":"Predicting venous thromboembolism risk from endogenous thrombin potential-based normalized activated protein C sensitivity ratio assay: toward early assessment of combined oral contraceptives.","journal":"Research and practice in thrombosis and haemostasis"},{"date":"2026 Apr","pmid":"41404846","title":"The impact of hormonal contraceptives containing estradiol, estradiol valerate, and estetrol on liver proteins, lipids, glucose, blood pressure, and bone. 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Further research is needed to determine its safety profile and efficacy. As a result, nomegestrol is not a commercially available treatment option.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}