{"id":"no-added-fluoride-in-a-silica-base","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dental fluorosis (due to potential cross-contamination)"}]},"_chembl":{"chemblId":"CHEMBL4170050","moleculeType":"Small molecule","molecularWeight":"336.44"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The silica base is used as a carrier for the drug, providing a stable and consistent delivery system. The lack of added fluoride is intended to reduce the risk of dental fluorosis and other potential side effects associated with fluoride exposure.","oneSentence":"This drug works by providing a silica base without added fluoride.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:23:09.914Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dental caries prevention"}]},"trialDetails":[{"nctId":"NCT01641237","phase":"PHASE3","title":"Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2012-03","conditions":"Enamel Erosion","enrollment":72}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"no added fluoride in a silica base","genericName":"no added fluoride in a silica base","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This drug works by providing a silica base without added fluoride. Used for Dental caries prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}