{"id":"nmba-cisatracurium","safety":{"commonSideEffects":[{"rate":null,"effect":"Histamine release (flushing, hypotension, tachycardia)"},{"rate":null,"effect":"Prolonged neuromuscular blockade"},{"rate":null,"effect":"Anaphylaxis"},{"rate":null,"effect":"Bronchospasm"}]},"_chembl":{"chemblId":"CHEMBL1201248","moleculeType":"Small molecule","molecularWeight":"929.16"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cisatracurium binds to nicotinic acetylcholine receptors on the motor endplate, preventing acetylcholine from binding and triggering muscle contraction. It is metabolized by Hofmann elimination (temperature and pH-dependent degradation) and ester hydrolysis, making it suitable for patients with hepatic or renal impairment. The drug is used during anesthesia to facilitate intubation and maintain muscle relaxation during surgery.","oneSentence":"Cisatracurium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the neuromuscular junction to produce skeletal muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:19.591Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skeletal muscle relaxation during anesthesia for intubation and surgery"},{"name":"Mechanical ventilation support in intensive care settings"}]},"trialDetails":[{"nctId":"NCT04459533","phase":"","title":"Sparing in Neuromuscular Blockade in COVID 19 ICU","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2020-06-01","conditions":"Neuromuscular Blockade, Human Characteristics, Complication of Medical Care","enrollment":250},{"nctId":"NCT01899560","phase":"PHASE3","title":"ELASTANCE: Prospective Physiological Study of Lung Elastance in Recruitment and Derecruitment in Early Onset Mechanically Ventilated ARDS Patients","status":"COMPLETED","sponsor":"Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer","startDate":"2013-03","conditions":"Acute Respiratory Distress Syndrome","enrollment":12},{"nctId":"NCT02816567","phase":"PHASE4","title":"Laparoscopic Surgery and Abdominal Compliance","status":"UNKNOWN","sponsor":"CHU de Reims","startDate":"2016-01","conditions":"Patients Ongoing Elective Abdominal Laparoscopy","enrollment":180},{"nctId":"NCT01573715","phase":"PHASE4","title":"Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS)","status":"UNKNOWN","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2012-04","conditions":"Acute Respiratory Distress Syndrome","enrollment":40},{"nctId":"NCT02033733","phase":"","title":"When Cooling a Patient After Cardiac Arrest, Does Use of a Neuromuscular Blocking Agent Make Your Job Easier?","status":"UNKNOWN","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2014-01","conditions":"Postcardiac Arrest Therapeutic Hypothermia","enrollment":400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":58,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"NMBA - cisatracurium","genericName":"NMBA - cisatracurium","companyName":"CHU de Reims","companyId":"chu-de-reims","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cisatracurium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the neuromuscular junction to produce muscle paralysis. Used for Muscle relaxation during general anesthesia for surgical procedures, Facilitation of endotracheal intubation, Muscle relaxation in mechanically ventilated patients in intensive care.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}