{"id":"nitrous-oxide-oxygen","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dissociation/altered mental status"},{"rate":null,"effect":"Transient vitamin B12 depletion with chronic use"}]},"_chembl":{"chemblId":"CHEMBL1234579","moleculeType":"Small molecule","molecularWeight":"44.01"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nitrous oxide (N2O) is a rapid-acting inhalational anesthetic that produces dissociation and analgesia through antagonism of NMDA glutamate receptors and potentiation of inhibitory GABAergic pathways. When combined with oxygen, it provides anxiolysis and pain relief while maintaining patient consciousness at lower concentrations, making it suitable for procedural sedation in pediatric settings. The gas is rapidly absorbed and eliminated via the lungs, allowing quick onset and offset of effects.","oneSentence":"Nitrous oxide acts as a dissociative anesthetic and analgesic by modulating NMDA receptor activity and enhancing inhibitory neurotransmission in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:22:40.303Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Procedural sedation and analgesia in pediatric patients"},{"name":"Anxiolysis during minor surgical and dental procedures in children"}]},"trialDetails":[{"nctId":"NCT05528718","phase":"","title":"SMILE Trial - Imaging Sub-Study","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2023-03-07","conditions":"Major Depressive Disorder","enrollment":11},{"nctId":"NCT06867068","phase":"PHASE1","title":"Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery","status":"COMPLETED","sponsor":"Albert Einstein College of Medicine","startDate":"2016-10-04","conditions":"Anesthesia, Tooth Extraction","enrollment":73},{"nctId":"NCT07491874","phase":"NA","title":"Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal- A Multicenter Randomized Controlled Study","status":"NOT_YET_RECRUITING","sponsor":"Kaplan Medical Center","startDate":"2026-05-01","conditions":"Preterm Delivery, Cervical Cerclage, Cervical Insufficiency","enrollment":60},{"nctId":"NCT05883332","phase":"PHASE4","title":"A Pilot Study to Assess Effects of Self-Administered Nitrous Oxide (SANO) on Urodynamic Study (UDS) Parameters","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2023-01-10","conditions":"Lower Urinary Tract Symptoms","enrollment":19},{"nctId":"NCT05710887","phase":"PHASE2","title":"N2O for Acute Suicidality and Depression in the ED","status":"WITHDRAWN","sponsor":"University of Chicago","startDate":"2026-02-27","conditions":"Suicidal Ideation, Major Depressive Disorder, Treatment Resistant Depression","enrollment":""},{"nctId":"NCT06928740","phase":"NA","title":"Efficacy on Anxiety of the Digital Music Application Versus Equimolar Mixture of Oxygen and Nitrous Oxide in Patients Receiving CT-guided Lumbar Infiltration","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2025-10-21","conditions":"Low Back Pain, Anxiety","enrollment":128},{"nctId":"NCT05895383","phase":"PHASE4","title":"Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy","status":"RECRUITING","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2023-05-24","conditions":"Procedural Pain, Pain Catastrophizing, Procedural Anxiety","enrollment":35},{"nctId":"NCT06622291","phase":"PHASE4","title":"Perioperative Nitric Oxide Prevents Acute Kidney Injury in Acute Type A Aortic Dissection Patients","status":"COMPLETED","sponsor":"Beijing Anzhen Hospital","startDate":"2024-11-30","conditions":"Acute Kidney Injury, Nitrous Oxide, Acute Type A Aortic Dissection","enrollment":106},{"nctId":"NCT07387315","phase":"PHASE4","title":"A Randomized, Placebo-controlled Trial of Nitrous Oxide During In-office Bladder Botox Injections","status":"NOT_YET_RECRUITING","sponsor":"TriHealth Inc.","startDate":"2026-02","conditions":"Overactive Bladder, Neurogenic Bladder, Urge Incontinence","enrollment":96},{"nctId":"NCT07384988","phase":"PHASE2","title":"The Impact of Nitrous Oxide Sedation on Dental Fear and Anxiety Scores in Children Aged 6-10 Years","status":"COMPLETED","sponsor":"Shaoxing Maternity and Child Health Care Hospital","startDate":"2024-01-15","conditions":"Dental Anxiety","enrollment":60},{"nctId":"NCT00430989","phase":"PHASE4","title":"The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial","status":"COMPLETED","sponsor":"Bayside Health","startDate":"2007-04","conditions":"Coronary Artery Disease","enrollment":7112},{"nctId":"NCT05357040","phase":"PHASE2","title":"Antidepressant Effects of Nitrous Oxide","status":"RECRUITING","sponsor":"University of Chicago","startDate":"2021-06-30","conditions":"Major Depressive Disorder, Treatment Resistant Depression","enrollment":172},{"nctId":"NCT05357066","phase":"PHASE2","title":"Nitrous Oxide as Treatment for Fibromyalgia","status":"RECRUITING","sponsor":"University of Chicago","startDate":"2021-11-12","conditions":"Fibromyalgia, Central Neuropathic Pain","enrollment":50},{"nctId":"NCT07299006","phase":"NA","title":"Evaluation of Paro, a Therapeutic Assistance Robot in Analgesic Management During the Placement of a Peripheral Intravenous Line in Infants and Children.","status":"NOT_YET_RECRUITING","sponsor":"Fondation Lenval","startDate":"2026-01-15","conditions":"Pain Management","enrollment":120},{"nctId":"NCT04199143","phase":"NA","title":"Brain Reactivity to Nitrous Oxyde in Depression : an MRI and Ultrasound Study (PROTOBRAIN Pilote)","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2020-02-20","conditions":"Treatment Resistant Depression, Nitrous Oxyde","enrollment":30},{"nctId":"NCT03736538","phase":"PHASE1","title":"Nitrous Oxide- Suicidal Ideation","status":"ENROLLING_BY_INVITATION","sponsor":"Washington University School of Medicine","startDate":"2018-10-30","conditions":"Major Depressive Disorder, Depression, Mood Disorders","enrollment":50},{"nctId":"NCT06702631","phase":"EARLY_PHASE1","title":"Nitrous Oxide Neuroimaging","status":"RECRUITING","sponsor":"Keith M Vogt","startDate":"2025-01-13","conditions":"Anesthesia, Pain, Amnesia","enrollment":60},{"nctId":"NCT07262008","phase":"PHASE3","title":"Sustained Mood Improvement With Laughing Gas Exposure","status":"NOT_YET_RECRUITING","sponsor":"Women's College Hospital","startDate":"2026-02-01","conditions":"Major Depressive Disorder, Treatment Resistant Depression","enrollment":120},{"nctId":"NCT06725134","phase":"NA","title":"Impact of Therapy Dogs on Child Anxiety and Behavior During Local Anesthesia for Dental Procedures","status":"RECRUITING","sponsor":"University of Michigan","startDate":"2024-11-01","conditions":"Situational Anxiety, Behavior","enrollment":25},{"nctId":"NCT05007028","phase":"NA","title":"Nitrous Oxide for Late-Life Depression - PROTO-BRAIN","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2021-11-16","conditions":"Late-Life Depression, Resistant Depression, Treatment","enrollment":60},{"nctId":"NCT07245628","phase":"EARLY_PHASE1","title":"A Trial of Self-Adjusted Nitrous Versus Placebo During Office Vasectomy","status":"RECRUITING","sponsor":"Alexandra J. Berger Eberhardt, MD","startDate":"2025-10-20","conditions":"Vasectomy","enrollment":50},{"nctId":"NCT07237854","phase":"NA","title":"Effect of Training Intensity on Microvascular Function","status":"COMPLETED","sponsor":"Université Libre de Bruxelles","startDate":"2022-01-22","conditions":"Vascular Remodeling, Sedentary Behavior, Hemodynamic Rebound","enrollment":25},{"nctId":"NCT01087229","phase":"PHASE4","title":"Effectiveness of an Oxygen-nitrous Oxide Mixture During Physical Therapy for Frozen Shoulder","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2010-03","conditions":"Adhesive Capsulitis","enrollment":75},{"nctId":"NCT02420002","phase":"PHASE4","title":"Pediatric Emergency Suture Care: a Trial Comparing the Analgesic Efficacy of Hypnosis Versus MEOPA","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2016-10-25","conditions":"Wounds, Nonpenetrating","enrollment":60},{"nctId":"NCT05890898","phase":"NA","title":"Virtual Reality vs Nitrous Oxide in Pediatric Dentistry","status":"COMPLETED","sponsor":"Geisinger Clinic","startDate":"2023-09-19","conditions":"Pediatric Dentistry","enrollment":62},{"nctId":"NCT00646945","phase":"PHASE4","title":"Study of the Efficacy of Kalinox® 170 Bar in Adult Oncology","status":"COMPLETED","sponsor":"Air Liquide Santé International","startDate":"2007-09","conditions":"Cancer, Pain","enrollment":204},{"nctId":"NCT00643838","phase":"PHASE3","title":"Use of 50% Nitrous Oxide / 50% Oxygen Premix in Primary Care Dental Centers","status":"COMPLETED","sponsor":"Air Liquide Santé International","startDate":"2007-12","conditions":"Dental Cares","enrollment":549},{"nctId":"NCT01581450","phase":"PHASE1","title":"Hyperalgesia and Pain","status":"COMPLETED","sponsor":"Air Liquide Santé International","startDate":"2012-01","conditions":"Hyperalgesia","enrollment":20},{"nctId":"NCT00210158","phase":"PHASE2","title":"Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment","status":"COMPLETED","sponsor":"Institut Bergonié","startDate":"2005-01-01","conditions":"Chronic Pain","enrollment":39},{"nctId":"NCT03826693","phase":"PHASE2","title":"Efficacy of Nitrous Oxide in OCD: Pilot Study","status":"RECRUITING","sponsor":"Stanford University","startDate":"2021-04-17","conditions":"Obsessive-Compulsive Disorder","enrollment":45},{"nctId":"NCT06996561","phase":"PHASE2, PHASE3","title":"Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management","status":"NOT_YET_RECRUITING","sponsor":"Dr. Asma Abdus Salam","startDate":"2025-09-01","conditions":"Cholecystectomy, Hernia, Abdominal, Appendectomy","enrollment":263},{"nctId":"NCT07118644","phase":"PHASE3","title":"Microbiote's Evolution After Use of Nitrous Oxide on Pediatric Patient Needing Airway Samples","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Brest","startDate":"2025-09-01","conditions":"Respiratory Ilness, Children","enrollment":40},{"nctId":"NCT06557642","phase":"NA","title":"Nitrous Oxide and EMOtional Cognition","status":"RECRUITING","sponsor":"University of Oxford","startDate":"2024-07-10","conditions":"Depression","enrollment":88},{"nctId":"NCT07074795","phase":"NA","title":"Use of Nitrous Oxide During Office Hysteroscopy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Maaynei Hayesha Medical Center","startDate":"2025-07-01","conditions":"Abnormal Uterine Bleeding, Postmenopausal Bleeding, Endometrial Polyps","enrollment":400},{"nctId":"NCT05178849","phase":"NA","title":"QUALHYBOM Hypnosis Versus Equimolar Mixture of Oxygen and Nitrous Oxide (MEOPA) During a Bone Marrow Biopsy: a Clinical, Controlled, Randomized, Multicenter Study","status":"COMPLETED","sponsor":"Rennes University Hospital","startDate":"2023-06-19","conditions":"Bone Marrow Biopsy","enrollment":180},{"nctId":"NCT06595303","phase":"","title":"Nitrous Oxyde During Labour","status":"COMPLETED","sponsor":"Erasme University Hospital","startDate":"2024-11-05","conditions":"Nitrous Oxide, Labour Analgesia","enrollment":70},{"nctId":"NCT05383495","phase":"PHASE3","title":"Anxiolysis for Laceration Repair in Children","status":"RECRUITING","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2023-12-19","conditions":"Laceration of Skin, Distress, Emotional","enrollment":300},{"nctId":"NCT03167905","phase":"PHASE2, PHASE3","title":"CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery)","status":"ACTIVE_NOT_RECRUITING","sponsor":"KK Women's and Children's Hospital","startDate":"2017-06-15","conditions":"Depression, Postpartum, Analgesia, Obstetrical, Anesthesia, Obstetrical","enrollment":881},{"nctId":"NCT06118567","phase":"PHASE2","title":"Effect of Nitrous Oxide on Aggression.","status":"RECRUITING","sponsor":"Ohio State University","startDate":"2022-09-06","conditions":"Intermittent Explosive Disorder","enrollment":50},{"nctId":"NCT00643656","phase":"PHASE4","title":"Use of 50% Nitrous Oxide / 50% Oxygen Premix During Liver Biopsy of Focal Lesion","status":"COMPLETED","sponsor":"Air Liquide Santé International","startDate":"2007-10","conditions":"Liver Biopsy","enrollment":94},{"nctId":"NCT04962672","phase":"NA","title":"Anesthesia Induced Brain Cancer Survival (ABC Survival): A Feasibility Study","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2022-01-01","conditions":"Anesthesia, Brain Cancer, Survival","enrollment":40},{"nctId":"NCT06636357","phase":"PHASE2","title":"Nitrous Oxide in the Treatment of Acute Suicidal Ideation","status":"RECRUITING","sponsor":"University of Zurich","startDate":"2025-01-13","conditions":"Suicidality, EEG, Suicidal Ideation","enrollment":85},{"nctId":"NCT05042479","phase":"NA","title":"Using of Virtual Reality to Relieve Procedural Pain in Pediatric Oncology.","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2022-06-30","conditions":"Hematologic Malignancy, Hematologic Non Malignancy, Solid Tumor, Childhood","enrollment":34},{"nctId":"NCT06740903","phase":"PHASE2, PHASE3","title":"Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy","status":"RECRUITING","sponsor":"Sahiwal medical college sahiwal","startDate":"2024-08-06","conditions":"Hemodynamics Instability, Post Operative Pain, Gastrointestinal Dysfunction","enrollment":140},{"nctId":"NCT03869736","phase":"PHASE2","title":"Nitrous Oxide for the Treatment of Major Depressive Disorder","status":"COMPLETED","sponsor":"Bayside Health","startDate":"2019-01-22","conditions":"Depression, Major Depressive Disorder","enrollment":81},{"nctId":"NCT01744184","phase":"PHASE4","title":"A Single-centre Study of Entonox Versus Midazolam Sedation in Gastroscopy","status":"TERMINATED","sponsor":"The Royal Bournemouth Hospital","startDate":"2013-05","conditions":"Patients Requiring Diagnostic Gastroscopy With Sedation","enrollment":62},{"nctId":"NCT06661005","phase":"EARLY_PHASE1","title":"Nitrous Oxide for Pain Management During In-Office Gynecology Procedures","status":"TERMINATED","sponsor":"University of Arizona","startDate":"2021-05-17","conditions":"Nitrous Oxide","enrollment":3},{"nctId":"NCT05126459","phase":"PHASE3","title":"A Comparison of Oral Sedation-related Events of Three Multiagent Oral Sedation Regimens in Pediatric Dental Patients","status":"COMPLETED","sponsor":"Loma Linda University","startDate":"2022-02-14","conditions":"Anxiety, Dental, Dental Decay","enrollment":60},{"nctId":"NCT06539013","phase":"NA","title":"Efficacy of Remifentanil in Preventing Emergence Agitation","status":"RECRUITING","sponsor":"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital","startDate":"2024-08-01","conditions":"Emergence Agitation","enrollment":99},{"nctId":"NCT06498908","phase":"PHASE3","title":"Intracervical Balloon Placement With Nitrous Oxide Administration","status":"RECRUITING","sponsor":"Maimonides Medical Center","startDate":"2024-05-15","conditions":"Labor Pain, Induced; Birth","enrollment":162},{"nctId":"NCT06430489","phase":"PHASE2","title":"Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Tours","startDate":"2024-06","conditions":"Suicidal Ideation, Emergency Psychiatric, Nitrous Oxide","enrollment":30},{"nctId":"NCT04957368","phase":"PHASE4","title":"Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2021-11-03","conditions":"Treatment Resistant Depression, Major Depressive Disorder","enrollment":40},{"nctId":"NCT01622335","phase":"NA","title":"Effect OF Nitrous Oxide On Acute Pain and Opioid Consumption, and Chronic Pain After Hysterectomy","status":"WITHDRAWN","sponsor":"The Cleveland Clinic","startDate":"2012-05","conditions":"Abdominal Hysterectomy (& Wertheim), Nitrous Oxide, General Anesthesia","enrollment":""},{"nctId":"NCT06382389","phase":"PHASE2","title":"Efficacy of EMONO as an add-on Therapy to Conventional Antidepressants for the Treatment of Depressive Symptoms in Nursing-home Residents With Neurocognitive Disorders: a Randomized Controlled Trial-","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Tours","startDate":"2024-06","conditions":"Depression, Neurocognitive Disorders","enrollment":96},{"nctId":"NCT05435118","phase":"NA","title":"Use of the Equimolar Mixture of Oxide Nitrous and Oxygen (EMONO) Associated With Audiovisuals in Children","status":"COMPLETED","sponsor":"Azienda Socio Sanitaria Territoriale di Lodi","startDate":"2023-08-17","conditions":"Pain, Acute, Child, Only, Nurse's Role","enrollment":120},{"nctId":"NCT04002128","phase":"NA","title":"Tracheal Colonization and Outcome After Major Abdominal Cancer Surgery","status":"COMPLETED","sponsor":"Osijek University Hospital","startDate":"2008-01","conditions":"Colorectal Neoplasms Malignant, Surgical Procedures, Operative, Stomach Neoplasms","enrollment":120},{"nctId":"NCT04305158","phase":"EARLY_PHASE1","title":"Colonoscopy Using Nitrous Oxide- A Pilot Study in the USA","status":"COMPLETED","sponsor":"University of Arkansas","startDate":"2022-03-28","conditions":"Nitrous Oxide","enrollment":200},{"nctId":"NCT05510141","phase":"NA","title":"Virtual Reality Games in Pediatric Surgery","status":"RECRUITING","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2022-08-24","conditions":"Analgesia, Surgical Procedure, Unspecified, Immersion","enrollment":100},{"nctId":"NCT06352606","phase":"NA","title":"Spinal and General Anesthesia in Neonates Undergoing Herniorrhaphy","status":"RECRUITING","sponsor":"Tanta University","startDate":"2024-04-06","conditions":"Spinal Anesthesia, General Anesthesia, Neonates","enrollment":74},{"nctId":"NCT04749043","phase":"NA","title":"Virtual Reality Compared to Nitrous Oxide for Labor Analgesia","status":"COMPLETED","sponsor":"Brendan Carvalho","startDate":"2021-02-18","conditions":"Labor Pain","enrollment":20},{"nctId":"NCT03879538","phase":"PHASE3","title":"Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2019-07-02","conditions":"Complex Regional Pain Syndrome","enrollment":44},{"nctId":"NCT05803096","phase":"PHASE4","title":"Self-Administered Nitrous Oxide (SANO) During Transrectal Prostate Biopsy to Reduce Patient Anxiety and Pain","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2021-12-12","conditions":"Prostate Disease, Malignancy, Benign Prostatic Hyperplasia","enrollment":143},{"nctId":"NCT03069638","phase":"PHASE4","title":"Intranasal Dexmedetomidine Sedation During Intra-articular Joint Injections in Pediatric Population","status":"COMPLETED","sponsor":"University of Oulu","startDate":"2017-02-01","conditions":"Juvenile Idiopathic Arthritis, Joint Inflammation","enrollment":68},{"nctId":"NCT01622322","phase":"NA","title":"Nitrous Oxide On Acute Postoperative Pain and Opioid Consumption and Chronic Pain After Inguinal Hernia Repair Surgery","status":"WITHDRAWN","sponsor":"The Cleveland Clinic","startDate":"2012-05","conditions":"Inguinal Hernia Repair, Post Operative Pain","enrollment":""},{"nctId":"NCT03674346","phase":"NA","title":"Efficacy of Hypnoanalgesia by a Radiologist Technologist in Children With Cutaneous Angioma Treated With Sclerosis in Interventional Radiology","status":"UNKNOWN","sponsor":"Hospices Civils de Lyon","startDate":"2024-01","conditions":"Angioma","enrollment":138},{"nctId":"NCT06056492","phase":"NA","title":"Effectiveness of Children Experiencing Nitrous Oxide/Oxygen Inhalation Sedation at an Assessment Visit Before Having Treatment.","status":"COMPLETED","sponsor":"Dr Richard Balmer","startDate":"2020-03-01","conditions":"Dental Anxiety","enrollment":20},{"nctId":"NCT06044753","phase":"NA","title":"Comparing the Effectiveness of Virtual Reality in Paediatric Patients","status":"COMPLETED","sponsor":"Universiti Kebangsaan Malaysia Medical Centre","startDate":"2020-12-01","conditions":"Pediatric Population, Preoperative Anxiety","enrollment":60},{"nctId":"NCT05430750","phase":"PHASE4","title":"Global Warming Impact of Nitrous Oxide","status":"COMPLETED","sponsor":"Sir Ganga Ram Hospital","startDate":"2022-06-29","conditions":"Global Warming Effect of Nitrous Oxide","enrollment":102},{"nctId":"NCT04398017","phase":"NA","title":"MEOPA-coupled Hypnosis Versus MEOPA-standard Care in Transesophageal Echocardiography","status":"TERMINATED","sponsor":"University Hospital, Strasbourg, France","startDate":"2020-10-14","conditions":"Cardiac Diseases","enrollment":80},{"nctId":"NCT02351869","phase":"PHASE2","title":"Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder","status":"TERMINATED","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2015-08","conditions":"Bipolar Disorder","enrollment":25},{"nctId":"NCT04984122","phase":"NA","title":"Anesthesia on Postoperative Pain After Loop Electrosurgical Excision Procedure","status":"COMPLETED","sponsor":"Erzincan Military Hospital","startDate":"2021-08-09","conditions":"Procedure, Gynecologic Surgical","enrollment":248},{"nctId":"NCT04378426","phase":"PHASE2","title":"Nitrous Oxide for PTSD","status":"TERMINATED","sponsor":"VA Office of Research and Development","startDate":"2021-10-07","conditions":"PTSD","enrollment":1},{"nctId":"NCT04302350","phase":"NA","title":"Nitrous Oxide for Identifying the Intersegmental Plane in Segmentectomy: A Randomized Controlled Trial","status":"COMPLETED","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2020-01-15","conditions":"Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer","enrollment":81},{"nctId":"NCT05388942","phase":"NA","title":"Virtual Reality Hypnosis Versus Inhaled Nitrous Oxide in Anterior Shoulder Dislocation Reduction: an Open Multicenter Randomized Controlled Trial","status":"UNKNOWN","sponsor":"CHU de Reims","startDate":"2022-10-09","conditions":"Shoulder Dislocation","enrollment":126},{"nctId":"NCT04008628","phase":"NA","title":"Nitrous Oxide for Analgesia During Nasogastric Tube Placement in Young Children","status":"UNKNOWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2021-12-10","conditions":"Mild to Moderate Dehydration","enrollment":160},{"nctId":"NCT02783508","phase":"NA","title":"Pethidine Versus Nitrous Oxide for Pain Relief During Labor","status":"COMPLETED","sponsor":"HaEmek Medical Center, Israel","startDate":"2016-08","conditions":"Labor Pain","enrollment":214},{"nctId":"NCT03420586","phase":"NA","title":"Nitrous Oxide Added at the End of Sevoflurane Anesthesia and Recovery","status":"COMPLETED","sponsor":"General Hospital Zadar","startDate":"2018-02-07","conditions":"Elective Surgical Procedures, Laparoscopy, Laparotomy","enrollment":100},{"nctId":"NCT05579288","phase":"EARLY_PHASE1","title":"Use of Nitrous Oxide for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Dilatation and Evacuation","status":"UNKNOWN","sponsor":"Sheba Medical Center","startDate":"2022-12","conditions":"Pain Alleviation, Dilatation and Evacuation, Laminaria Placement","enrollment":60},{"nctId":"NCT04089852","phase":"PHASE2, PHASE3","title":"Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women","status":"WITHDRAWN","sponsor":"Boston Children's Hospital","startDate":"2021-06-01","conditions":"Contraceptive Devices, Long-Acting Reversible Contraception, Analgesia","enrollment":""},{"nctId":"NCT00212147","phase":"NA","title":"Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2003-09","conditions":"Avitaminosis, Delirium, Dementia, Amnestic, Cognitive Disorders","enrollment":444},{"nctId":"NCT03085563","phase":"PHASE4","title":"A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2017-05-24","conditions":"Conscious Sedation, Simple Lacerations Less Than 4 cm, Lumbar Punctures","enrollment":63},{"nctId":"NCT04099693","phase":"","title":"A Prospective Randomized Study of General Anesthesia Versus Anesthetist Administered Sedation for ERCP","status":"UNKNOWN","sponsor":"King Abdullah Medical City","startDate":"2019-09-08","conditions":"Anesthesia","enrollment":204},{"nctId":"NCT03283670","phase":"PHASE2","title":"Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2016-11-22","conditions":"Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant","enrollment":24},{"nctId":"NCT04168983","phase":"NA","title":"Impact of Sophrology on the Pain Felt During a Bone Marrow Aspiration and Biopsy","status":"COMPLETED","sponsor":"University Hospital, Caen","startDate":"2019-09-25","conditions":"Hematologic Diseases, Diagnoses Disease, Pain","enrollment":90},{"nctId":"NCT05167331","phase":"NA","title":"Comparative Clinical Study Between Virtual Reality Hypnosis and Nitrous Oxide Inhalation for Dental Anxie","status":"UNKNOWN","sponsor":"University Hospital, Strasbourg, France","startDate":"2022-02","conditions":"Dental Anxiety","enrollment":30},{"nctId":"NCT03717961","phase":"PHASE3","title":"Efficacy of Botulinum Toxin A in Adult Subjects With Raynaud Phenomenon Secondary to Systemic Sclerosis","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2018-10-15","conditions":"Raynaud Phenomenon Secondary to Systemic Sclerosis","enrollment":91},{"nctId":"NCT05139212","phase":"","title":"Determination of Optimum Time for Intravenous Cannulation in Children With Dexmedetomidine Premedication","status":"COMPLETED","sponsor":"Karaman Training and Research Hospital","startDate":"2021-12-02","conditions":"Cannulation, Sevoflurane Induction, Dexmedetomidine","enrollment":40},{"nctId":"NCT02534012","phase":"NA","title":"Paravertebral Block vs. General Anesthesia for Major Abdominal Surgery","status":"UNKNOWN","sponsor":"Makassed General Hospital","startDate":"2016-05-01","conditions":"Major Abdominal Surgery","enrollment":60},{"nctId":"NCT02679781","phase":"NA","title":"Nasal Versus Oral Midazolam Sedation in Routine Pediatric Dental Care","status":"COMPLETED","sponsor":"Hadassah Medical Organization","startDate":"2017-03-28","conditions":"Conscious Sedation","enrollment":70},{"nctId":"NCT04884893","phase":"PHASE1","title":"Effect of Nitrous Oxide on EEG","status":"COMPLETED","sponsor":"Tampere University Hospital","startDate":"2021-05-21","conditions":"Nitrous Oxide, Electroencephalography, Anesthetic, Inhalation","enrollment":20},{"nctId":"NCT04310748","phase":"NA","title":"Effects of TIVA and Inhalation Anesthesia on Oxidative Stress Factors During Hypotensive Anesthesia","status":"COMPLETED","sponsor":"Bezmialem Vakif University","startDate":"2020-05-01","conditions":"Oxidative Stress, Anesthesia","enrollment":60},{"nctId":"NCT04521556","phase":"PHASE4","title":"Effect of Epidural Anesthesia and Analgesia on Quality of Recovery After Unilateral Nephrectomy.","status":"COMPLETED","sponsor":"University Hospital of Split","startDate":"2019-04-01","conditions":"Anesthesia, Anesthesia Recovery Period, Nephrectomy","enrollment":80},{"nctId":"NCT04587505","phase":"PHASE4","title":"Effect of Epidural Anesthesia and Analgesia on Quality of Recovery After Radical Prostatectomy.","status":"COMPLETED","sponsor":"University Hospital of Split","startDate":"2019-04-01","conditions":"Anesthesia, Anesthesia Recovery Period, Radical Prostatectomy","enrollment":61},{"nctId":"NCT02994433","phase":"PHASE1","title":"NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits","status":"TERMINATED","sponsor":"Washington University School of Medicine","startDate":"2017-01-27","conditions":"Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant","enrollment":49},{"nctId":"NCT03127371","phase":"NA","title":"Adjunctive Nitrous Oxide During ED Incision and Drainage of Abscess","status":"TERMINATED","sponsor":"Albert Einstein Healthcare Network","startDate":"2016-09","conditions":"Abscess","enrollment":41},{"nctId":"NCT03932825","phase":"PHASE2","title":"Nitrous Oxide for Major Depressive Disorder","status":"COMPLETED","sponsor":"Lingjiang Li","startDate":"2019-04-01","conditions":"Depressive Disorder, Major Depressive Disorder, Treatment Resistant Depression","enrollment":44},{"nctId":"NCT03453411","phase":"","title":"Effects of EMONO in Children During Dental Care","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2018-05-17","conditions":"Dental Care","enrollment":679},{"nctId":"NCT04813874","phase":"","title":"Nitrous Oxide and Neuraxial Labor Analgesia Use on Maternal Fetal Outcomes","status":"WITHDRAWN","sponsor":"Brigham and Women's Hospital","startDate":"2016-07-01","conditions":"Pregnancy","enrollment":""},{"nctId":"NCT03956264","phase":"NA","title":"Interest of Virtual Reality in the Management of Anxiety and Pain Related to Post-cardiac Surgery Care","status":"COMPLETED","sponsor":"CMC Ambroise Paré","startDate":"2019-09-26","conditions":"Surgery, Cardiac","enrollment":200},{"nctId":"NCT01958138","phase":"PHASE2, PHASE3","title":"Isoflurane Versus Propofol for Removal of LMA in Children","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2012-04","conditions":"Complication of Anesthesia","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[{"date":"20130903","type":"ORIG","sponsor":"NITROUS OXIDE CORP","applicationNumber":"NDA206009"}],"publicationCount":1270,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Nitrous Oxide/Oxygen","genericName":"Nitrous Oxide/Oxygen","companyName":"Nationwide Children's Hospital","companyId":"nationwide-children-s-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nitrous oxide acts as a dissociative anesthetic and analgesic by modulating NMDA receptor activity and enhancing inhibitory neurotransmission in the central nervous system. Used for Procedural sedation and analgesia in pediatric patients, Anxiolysis and pain relief during minor medical and dental procedures, Emergency analgesia and sedation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}