{"id":"nitrous-oxide-99","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness or lightheadedness"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dissociation or altered mental status"},{"rate":null,"effect":"Vitamin B12 depletion with chronic use"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nitrous oxide binds to NMDA receptors and inhibits their function, leading to dissociation, analgesia, and mild anesthesia. It has rapid onset and offset due to its low blood solubility and is commonly used in combination with other anesthetics or analgesics for procedural sedation and pain relief. The drug does not significantly depress respiratory or cardiovascular function at sub-anesthetic doses.","oneSentence":"Nitrous oxide acts as a dissociative anesthetic and analgesic by antagonizing N-methyl-D-aspartate (NMDA) receptors in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:20.771Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Analgesia and sedation during surgical and dental procedures"},{"name":"Acute pain relief in emergency and prehospital settings"},{"name":"Anxiolysis during medical procedures"}]},"trialDetails":[{"nctId":"NCT04957368","phase":"PHASE4","title":"Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2021-11-03","conditions":"Treatment Resistant Depression, Major Depressive Disorder","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Nitrous Oxide 99 %","genericName":"Nitrous Oxide 99 %","companyName":"Unity Health Toronto","companyId":"unity-health-toronto","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nitrous oxide acts as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor, producing dissociative anesthesia and analgesia. Used for Anesthesia (induction and maintenance), Analgesia for acute pain and dental procedures, Anxiolysis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}