{"id":"nitroglycerin-ntg","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Headache"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Hypotension"},{"rate":"5","effect":"Tachycardia"},{"rate":"5-10","effect":"Flushing"},{"rate":"variable","effect":"Nitrate tolerance (with chronic use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nitroglycerin is metabolized to nitric oxide, which activates guanylate cyclase and increases cGMP levels in vascular smooth muscle cells, leading to vasodilation. This reduces venous return (preload) and systemic vascular resistance (afterload), decreasing myocardial oxygen demand and improving coronary blood flow. The drug is particularly effective for acute anginal episodes and chronic angina management.","oneSentence":"Nitroglycerin is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and dilate blood vessels, reducing cardiac preload and afterload.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:21.793Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute angina pectoris (sublingual/spray formulation)"},{"name":"Chronic stable angina (long-acting formulations)"},{"name":"Acute myocardial infarction"},{"name":"Heart failure with pulmonary edema"}]},"trialDetails":[{"nctId":"NCT06682260","phase":"PHASE4","title":"Evaluating the Effects of Nitroglycerin on Heart Function and Urinary Output in Patients With Acute Heart Failure","status":"COMPLETED","sponsor":"Copenhagen University Hospital, Hvidovre","startDate":"2025-02-01","conditions":"Acute Heart Failure (AHF)","enrollment":21},{"nctId":"NCT06273293","phase":"NA","title":"Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients (PROMETEUS TRIAL)","status":"RECRUITING","sponsor":"Fundación EPIC","startDate":"2024-05-31","conditions":"Coronary Disease","enrollment":150},{"nctId":"NCT07083063","phase":"PHASE4","title":"Precise Endoscopic Application of Nitroglycerin in Preventing Post-ERCP Pancreatitis","status":"RECRUITING","sponsor":"National Cheng-Kung University Hospital","startDate":"2025-09-15","conditions":"Pancreatitis","enrollment":440},{"nctId":"NCT06912139","phase":"PHASE3","title":"Topical Nitroglycerine for Prevention of Radial Artery Spasm","status":"COMPLETED","sponsor":"University of Medicine and Pharmacy \"Victor Babes\" Timisoara","startDate":"2023-04-01","conditions":"Radial Artery Spasm","enrollment":100},{"nctId":"NCT06637956","phase":"NA","title":"The Effect of Intranasally Administered Nitroglycerin on Hemodynamic Response to Laryngoscopy and Intubation Among Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery","status":"COMPLETED","sponsor":"Muhammad Aamir Latif","startDate":"2024-01-01","conditions":"Coronary Artery Bypass Grafting","enrollment":58},{"nctId":"NCT04972123","phase":"PHASE2","title":"The Effect of CPC on Aborting Tilt Induced Syncope in Patients With a History of Vasovagal Syncope or Near Syncope","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2021-07-20","conditions":"Syncope, Vasovagal","enrollment":143},{"nctId":"NCT05718310","phase":"NA","title":"Habituation of the Nociceptive Blink Reflex in Experimentally Induced Migraine Attack","status":"UNKNOWN","sponsor":"IRCCS National Neurological Institute \"C. 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Used for Acute angina pectoris (chest pain relief), Prophylaxis of angina pectoris, Heart failure (acute decompensated).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}