{"id":"nitrofurazone","rwe":[],"tags":[{"label":"nitrofurazone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sterile alpha and TIR motif-containing protein 1","category":"target"},{"label":"SARM1","category":"gene"},{"label":"G6PD","category":"gene"},{"label":"B05CA03","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Established","category":"status"},{"label":"Enterobacter Cystitis","category":"indication"},{"label":"Enterococcus Urinary Tract Infection","category":"indication"},{"label":"Escherichia coli urinary tract infection","category":"indication"},{"label":"Klebsiella cystitis","category":"indication"},{"label":"Staphylococcus Aureus Urinary Tract Infection","category":"indication"},{"label":"Staphylococcus Saprophyticus Urinary Tract Infection","category":"indication"},{"label":"Shire","category":"company"},{"label":"Approved 1940s","category":"decade"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"marketed","safety":{"contraindications":["Acute hepatitis","Anemia due to enzyme deficiency","Anuria","Cholestatic hepatitis","Chronic hepatitis","Cobalamin deficiency","Deficiency of glucose-6-phosphate dehydrogenase","Diabetes mellitus","Drug-induced hepatitis","Fibrosis of lung","Impaired renal function disorder","Interstitial pneumonia","Obstructive hyperbilirubinemia","Oliguria","Optic neuritis","Peripheral nerve disease","Pseudomembranous enterocolitis","Vitamin B deficiency"]},"trials":[],"aliases":[],"company":"Takeda","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=NITROFURAZONE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:43:43.566562+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:43:50.262031+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NITROFURAZONE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:43:51.066368+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: DNA inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:43:51.640869+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL869/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:43:51.535137+00:00"}},"allNames":"furacin","offLabel":[],"synonyms":["nitrofurazone","aldomycin","babrocid","furacilin","furacine","furacin","furacycline","furaldon","furaziline","nifuzon","nitrofural","nitrofuraldehyde semicarbazone","nitrofuran","nitrozone"],"timeline":[{"date":"1945-10-04","type":"positive","source":"DrugCentral","milestone":"FDA approval (Shire)"}],"aiSummary":"Furacin (NITROFURAZONE) is a small molecule nitrofurazone antibiotic developed by SHIRE, targeting Sterile alpha and TIR motif-containing protein 1. It was FDA approved in 1945 for various urinary tract infections caused by bacteria such as Enterobacter, Escherichia coli, Klebsiella, Staphylococcus Aureus, and Staphylococcus Saprophyticus. As an off-patent medication, Furacin is available from multiple generic manufacturers. Key safety considerations include the potential for allergic reactions and gastrointestinal side effects. 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reduction of ribonucleotides, leading to the disruption of DNA synthesis and function, ultimately resulting in bacterial cell death."},"commercial":{"launchDate":"1945","_launchSource":"DrugCentral (FDA 1945-10-04, SHIRE)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1950","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=NITROFURAZONE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NITROFURAZONE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange 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