{"id":"nitro-bid-2-topical-ointment","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Headache"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Hypotension"},{"rate":"5","effect":"Tachycardia"},{"rate":"1-5","effect":"Contact dermatitis (at application site)"}]},"_chembl":{"chemblId":"CHEMBL2108523","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nitroglycerine undergoes enzymatic bioconversion to produce nitric oxide, which activates guanylate cyclase and increases cGMP levels in vascular smooth muscle cells. This leads to vasodilation of both arteries and veins, reducing preload and afterload on the heart and improving coronary blood flow. The topical ointment formulation provides sustained, transdermal delivery for prolonged therapeutic effect.","oneSentence":"Nitroglycerine is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and improve blood flow.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:16.708Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Angina pectoris (prophylaxis and acute relief)"},{"name":"Congestive heart failure"}]},"trialDetails":[{"nctId":"NCT07391501","phase":"PHASE4","title":"Nitroglycerin Ointment for Pain Relief After Endoscopic Hemorrhoid Band Ligation","status":"NOT_YET_RECRUITING","sponsor":"Ying Zhu","startDate":"2026-02-01","conditions":"Internal Hemorrhoids, Postoperative Pain After Endoscopic Rubber Band Ligation","enrollment":68},{"nctId":"NCT07004764","phase":"PHASE1","title":"Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.","status":"NOT_YET_RECRUITING","sponsor":"Johns Hopkins University","startDate":"2026-03","conditions":"Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture","enrollment":15},{"nctId":"NCT06428669","phase":"PHASE4","title":"Effect of Nitropaste in Chest Masculinizing Surgery","status":"RECRUITING","sponsor":"University of Virginia","startDate":"2022-08-15","conditions":"Gender Dysphoria","enrollment":256},{"nctId":"NCT05590520","phase":"NA","title":"Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure","status":"UNKNOWN","sponsor":"Pak Emirates Military Hospital","startDate":"2022-11-01","conditions":"Fissure in Ano","enrollment":90},{"nctId":"NCT05239013","phase":"EARLY_PHASE1","title":"Safety and Tolerability of Nitro for Radial Artery Dilation","status":"UNKNOWN","sponsor":"Thomas Jefferson University","startDate":"2022-05-01","conditions":"Artery; Dilatation","enrollment":20},{"nctId":"NCT04685031","phase":"PHASE1, PHASE2","title":"Ointment Therapy and Prevention of Cannulation-Induced Superficial Phlebitis","status":"UNKNOWN","sponsor":"Komar University of Science and Technology","startDate":"2021-02-01","conditions":"Phlebitis","enrollment":110},{"nctId":"NCT02413268","phase":"PHASE3","title":"Topical Nitroglycerin To Prevent Radial Artery Occlusion After Transradial Access: NTP-RAO Trial","status":"UNKNOWN","sponsor":"Total Cardiovascular Solutions","startDate":"2016-03","conditions":"Total Atherosclerotic Occlusion of Radial Artery","enrollment":2400},{"nctId":"NCT04017845","phase":"EARLY_PHASE1","title":"Screening for Colorectal Cancer in Average and High Risk Population","status":"COMPLETED","sponsor":"Lewai Sharki Abdulaziz, MSc PhD","startDate":"2015-04-01","conditions":"Colorectal Neoplasms, Colorectal Cancer, Adenomatous Polyp of Colon","enrollment":537},{"nctId":"NCT02801305","phase":"PHASE2","title":"Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers","status":"COMPLETED","sponsor":"Mohammad Ali Nazarinia","startDate":"2016-06","conditions":"Digital Ulcer of Scleroderma","enrollment":90},{"nctId":"NCT00841594","phase":"PHASE1","title":"MQX-503 Applied to the Hand Versus Nitroglycerin Ointment Applied to the Chest: A Pharmacokinetic Comparison","status":"COMPLETED","sponsor":"MediQuest Therapeutics","startDate":"2009-02","conditions":"Raynaud's Phenomenon","enrollment":12},{"nctId":"NCT01279551","phase":"PHASE2, PHASE3","title":"Topical Application of GTN 0.4% in the Treatment of Anismus Following Stapled Haemorrhoidopexy","status":"COMPLETED","sponsor":"University of Roma La Sapienza","startDate":"2004-01","conditions":"Pain After Stapled Haemorrhoidopexy","enrollment":40},{"nctId":"NCT00513994","phase":"PHASE1","title":"MQX-503 vs Nitroglycerin Ointment: A Pharmacokinetic Comparison in Normal Subjects","status":"COMPLETED","sponsor":"MediQuest Therapeutics","startDate":"2007-08","conditions":"Healthy","enrollment":6}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Nitro-Bid 2 % Topical Ointment","genericName":"Nitro-Bid 2 % Topical Ointment","companyName":"University of Virginia","companyId":"university-of-virginia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nitroglycerine is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and improve blood flow. Used for Angina pectoris (prophylaxis and acute relief), Congestive heart failure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}