{"id":"nitric-oxide-plus-oxygen","safety":{"commonSideEffects":[{"rate":null,"effect":"Methemoglobinemia"},{"rate":null,"effect":"Rebound pulmonary hypertension upon discontinuation"},{"rate":null,"effect":"Nitrogen dioxide formation (oxidative stress)"}]},"_chembl":{"chemblId":"CHEMBL1200689","moleculeType":"Small molecule","molecularWeight":"30.01"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator that relaxes vascular smooth muscle in the lungs, reducing pulmonary vascular resistance and improving ventilation-perfusion matching. When combined with supplemental oxygen, this combination enhances systemic oxygenation while minimizing systemic hypotension, as nitric oxide is rapidly inactivated by hemoglobin.","oneSentence":"Nitric oxide gas combined with oxygen improves oxygenation and vasodilation in the lungs to reduce pulmonary hypertension and improve gas exchange.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:23:05.366Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute respiratory distress syndrome (ARDS)"},{"name":"Pulmonary hypertension in critically ill patients"},{"name":"Hypoxemic respiratory failure"}]},"trialDetails":[{"nctId":"NCT04305457","phase":"PHASE2","title":"Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19","status":"TERMINATED","sponsor":"Massachusetts General Hospital","startDate":"2020-03-21","conditions":"Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome","enrollment":62},{"nctId":"NCT07472283","phase":"","title":"Design, Development and Evaluation of a Digital Health Assistant for Paediatric Asthma","status":"NOT_YET_RECRUITING","sponsor":"University Children's Hospital Basel","startDate":"2026-04","conditions":"Paediatric Asthma","enrollment":42},{"nctId":"NCT02836899","phase":"PHASE3","title":"Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2017-02-08","conditions":"Acute Kidney Injury","enrollment":250},{"nctId":"NCT07444138","phase":"NA","title":"Effects of Beetroot Extract on Blood Pressure and Exercise in Hypertensive Older Women","status":"RECRUITING","sponsor":"São Paulo State University","startDate":"2025-10-08","conditions":"Hypertension, Hypertension (HTN)","enrollment":20},{"nctId":"NCT06622291","phase":"PHASE4","title":"Perioperative Nitric Oxide Prevents Acute Kidney Injury in Acute Type A Aortic Dissection Patients","status":"COMPLETED","sponsor":"Beijing Anzhen Hospital","startDate":"2024-11-30","conditions":"Acute Kidney Injury, Nitrous Oxide, Acute Type A Aortic Dissection","enrollment":106},{"nctId":"NCT05612074","phase":"EARLY_PHASE1","title":"Methemoglobin Concentration in High Dose Inhaled Nitric Oxide","status":"ACTIVE_NOT_RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2023-10-16","conditions":"Healthy Subjects","enrollment":10},{"nctId":"NCT03748082","phase":"PHASE2","title":"Effects of Nitric Oxide on the Endothelium During Hemolysis.","status":"WITHDRAWN","sponsor":"Massachusetts General Hospital","startDate":"2018-12-05","conditions":"Endothelial Dysfunction, Hemolysis Intravascular, Cardiovascular Diseases","enrollment":""},{"nctId":"NCT04962776","phase":"PHASE4","title":"Preoperative Coadministration of Low-concentration Carbohydrate and Nitrates Loading vs Low- Concentration Carbohydrate Loading Alone in Patients Undergoing Open Gynecological Surgeries","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2021-08-01","conditions":"Length of Hospital Stay","enrollment":90},{"nctId":"NCT05101746","phase":"PHASE2, PHASE3","title":"Nitric Oxide Effect on Brain and Kidney in Pediatric Patients Undergoing Cardiopulmonary Bypass","status":"ENROLLING_BY_INVITATION","sponsor":"Vanderbilt University Medical Center","startDate":"2022-04-25","conditions":"Congenital Heart Disease, Congenital Heart Defect, Congenital Heart Malformations","enrollment":50},{"nctId":"NCT05109611","phase":"PHASE3","title":"Nitric Oxide Nasal Spray (NONS) as Prevention for Treatment of Individuals at Risk of Exposure to COVID-19 Infection","status":"TERMINATED","sponsor":"Sanotize Research and Development corp.","startDate":"2021-11-20","conditions":"SARS-CoV-2 Infection","enrollment":1389},{"nctId":"NCT03023449","phase":"PHASE2","title":"Diffuse Optical Monitoring With Inhaled Nitric Oxide","status":"ACTIVE_NOT_RECRUITING","sponsor":"Steven Messe","startDate":"2017-04-04","conditions":"Stroke","enrollment":40},{"nctId":"NCT07099144","phase":"","title":"Inhaled Nitric Oxide for the Treatment of Neonatal Hypoxic Respiratory Failure With Pulmonary Hypertension","status":"RECRUITING","sponsor":"Lee's Pharmaceutical Limited","startDate":"2024-12-12","conditions":"Pulmonary Hypertension, Hypoxic Respiratory Failure","enrollment":120},{"nctId":"NCT04216927","phase":"PHASE3","title":"NO During CPB in Neonates to Reduce Risk of AKI","status":"RECRUITING","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2023-01-10","conditions":"AKI, CHD - Congenital Heart Disease, Surgery","enrollment":40},{"nctId":"NCT03260569","phase":"PHASE3","title":"Inhaled Nitric Oxide in Brain Injury","status":"COMPLETED","sponsor":"University of Cincinnati","startDate":"2018-12-12","conditions":"Traumatic Brain Injury","enrollment":13},{"nctId":"NCT05757557","phase":"PHASE1, PHASE2","title":"Perioperative Nitric Oxide Prevents Acute Kidney Injury in Cardiac Surgery Patients With Chronic Kidney Disease","status":"COMPLETED","sponsor":"Tomsk National Research Medical Center of the Russian Academy of Sciences","startDate":"2023-02-25","conditions":"Acute Kidney Disease, Chronic Kidney Disease, Cardiac Surgery","enrollment":136},{"nctId":"NCT06170372","phase":"NA","title":"High-dose Inhalations of Nitric Oxide in the Treatment of Pneumonia","status":"RECRUITING","sponsor":"Tomsk National Research Medical Center of the Russian Academy of Sciences","startDate":"2024-01-15","conditions":"Nosocomial Pneumonia, Community-acquired Pneumonia","enrollment":200},{"nctId":"NCT06660784","phase":"","title":"Mechanism of Nitric Oxide on Ventilator-induced Diaphragm Dysfunction with Extracorporeal Membrane Lung Assistance","status":"ACTIVE_NOT_RECRUITING","sponsor":"Zhongnan Hospital","startDate":"2024-01-16","conditions":"Tracheal Intubation, Extracorporeal Membrane Oxygenation, Nitric Oxide","enrollment":80},{"nctId":"NCT00515281","phase":"PHASE2, PHASE3","title":"Inhaled Nitric Oxide and Neuroprotection in Premature Infants","status":"TERMINATED","sponsor":"University of Chicago","startDate":"2008-05","conditions":"Prematurity, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage","enrollment":273},{"nctId":"NCT01165047","phase":"PHASE2","title":"Nitric Oxide, GeNO Nitrosyl Delivery System","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2010-09","conditions":"Pulmonary Arterial Hypertension","enrollment":10},{"nctId":"NCT04181359","phase":"PHASE1, PHASE2","title":"The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in Interstitial Lung Disease.","status":"WITHDRAWN","sponsor":"University of Alberta","startDate":"2024-09-01","conditions":"Dyspnea","enrollment":""},{"nctId":"NCT03661385","phase":"PHASE3","title":"Nitric Oxide During Bypass for Arterial Switch Operation","status":"COMPLETED","sponsor":"Murdoch Childrens Research Institute","startDate":"2018-07-11","conditions":"Low Cardiac Output Syndrome, Transposition of Great Vessels","enrollment":300},{"nctId":"NCT05877313","phase":"PHASE2","title":"Nitric Oxide Releasing Solution (NORS) For The Treatment Of Human Papillomavirus(HPV) Verrucae Plantaris (Plantar Warts)","status":"COMPLETED","sponsor":"Sanotize Research and Development corp.","startDate":"2023-08-02","conditions":"Verruca Plantaris","enrollment":20},{"nctId":"NCT04069052","phase":"EARLY_PHASE1","title":"The Effect of Inhaled Nitric Oxide on Deadspace in COPD","status":"COMPLETED","sponsor":"Dr. Denis O'Donnell","startDate":"2021-09-01","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":13},{"nctId":"NCT05052229","phase":"EARLY_PHASE1","title":"Inhaled Nitric Oxide (iNO) in Idiopathic Pulmonary Fibrosis (IPF).","status":"RECRUITING","sponsor":"Dr. Denis O'Donnell","startDate":"2022-04-21","conditions":"Idiopathic Pulmonary Fibrosis","enrollment":40},{"nctId":"NCT05686265","phase":"","title":"Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage","status":"TERMINATED","sponsor":"Rigshospitalet, Denmark","startDate":"2023-05-11","conditions":"Subarachnoid Hemorrhage, Aneurysmal","enrollment":3},{"nctId":"NCT06162455","phase":"NA","title":"High-dose Inhaled NO Therapy for the Prevention of Nosocomial Pneumonia After Cardiac Surgery With CPB","status":"COMPLETED","sponsor":"Tomsk National Research Medical Center of the Russian Academy of Sciences","startDate":"2023-11-17","conditions":"Nosocomial Pneumonia","enrollment":74},{"nctId":"NCT06097026","phase":"NA","title":"Role of Inhaled Nitric Oxide in Vascular Mechanics and Right Ventricular Function","status":"UNKNOWN","sponsor":"Fernando Suarez Sipmann","startDate":"2023-11-22","conditions":"Collapsed Lung, Hemodynamic Stability","enrollment":54},{"nctId":"NCT06213077","phase":"NA","title":"The Effects of a Nitrate Supplementation on Erectile Function","status":"UNKNOWN","sponsor":"RHA Investments Ltd","startDate":"2023-12-12","conditions":"Erectile Dysfunction","enrollment":20},{"nctId":"NCT03679312","phase":"PHASE1, PHASE2","title":"The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2018-09-04","conditions":"Dyspnea","enrollment":140},{"nctId":"NCT03267108","phase":"PHASE3","title":"A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension","status":"TERMINATED","sponsor":"Bellerophon Pulse Technologies","startDate":"2020-12-14","conditions":"Pulmonary Fibrosis, Pulmonary Hypertension","enrollment":145},{"nctId":"NCT05747508","phase":"PHASE2","title":"A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Hypertension Associated With Pulmonary Fibrosis","status":"UNKNOWN","sponsor":"Bellerophon","startDate":"2017-12-29","conditions":"Pulmonary Fibrosis, Pulmonary Hypertension","enrollment":85},{"nctId":"NCT01728220","phase":"PHASE2","title":"Two-Part Dose-Confirming Study of Pulsed Inhaled Nitric Oxide in Subjects With WHO Group 3 Pulmonary Hypertension Associated With COPD","status":"COMPLETED","sponsor":"Bellerophon Pulse Technologies","startDate":"2012-12","conditions":"Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease","enrollment":159},{"nctId":"NCT02267655","phase":"PHASE1","title":"3 Part Study to Assess Inhaled Nitric Oxide on Functional Pulmonary Imaging in Subj. Pulmonary Hypertension Associated w/ COPD and IPF","status":"COMPLETED","sponsor":"Bellerophon","startDate":"2015-05","conditions":"Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis","enrollment":8},{"nctId":"NCT03135860","phase":"EARLY_PHASE1","title":"Effect iNO on Functional Respiratory Imaging in Subjects With WHO Group 3 Pulmonary Hypertension With COPD on Oxygen","status":"TERMINATED","sponsor":"Bellerophon","startDate":"2016-10","conditions":"COPD, Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease","enrollment":7},{"nctId":"NCT03602781","phase":"PHASE3","title":"Study of PAH Subjects With LTOT Use That Have Demonstrated Improved Exercise Tolerance With the Use of Inhaled Nitric","status":"WITHDRAWN","sponsor":"Bellerophon Pulse Technologies","startDate":"2018-08","conditions":"Pulmonary Arterial Hypertension","enrollment":""},{"nctId":"NCT02725372","phase":"PHASE3","title":"Clinical Study of Pulsed, Inhaled Nitric Oxide Versus Placebo in Symptomatic Subjects With PAH","status":"TERMINATED","sponsor":"Bellerophon Pulse Technologies","startDate":"2016-04","conditions":"Pulmonary Arterial Hypertension","enrollment":207},{"nctId":"NCT05356052","phase":"","title":"Expanded Access for Patients With Pulmonary Hypertension Associated With Pulmonary Fibrosis","status":"AVAILABLE","sponsor":"Bellerophon","startDate":"","conditions":"Pulmonary Fibrosis, Pulmonary Hypertension","enrollment":""},{"nctId":"NCT05715788","phase":"","title":"Prone Positioning vs. Prone Positioning and NO Inhalation in COVID-19 ARDS.","status":"UNKNOWN","sponsor":"Shanghai Zhongshan Hospital","startDate":"2022-12-21","conditions":"Respiratory Distress Syndrome","enrollment":30},{"nctId":"NCT04476992","phase":"PHASE1, PHASE2","title":"Nitric Oxide Therapy for COVID-19 Patients With Oxygen Requirement","status":"COMPLETED","sponsor":"Tomsk National Research Medical Center of the Russian Academy of Sciences","startDate":"2020-07-24","conditions":"Hypoxemia, Pneumonia, Viral, Coronavirus Infection","enrollment":20},{"nctId":"NCT05599919","phase":"PHASE3","title":"Nitric Oxide Nasal Spray (NONS) To Treat and Prevent the Exacerbation of Infection in Individuals With Mild COVID-19","status":"COMPLETED","sponsor":"Sanotize Research and Development corp.","startDate":"2021-11-01","conditions":"SARS-CoV-2 Infection","enrollment":306},{"nctId":"NCT04026126","phase":"NA","title":"Effects of Passive Heat Therapy on Oxygen Consumption and Cardiovascular Fitness in Adults","status":"COMPLETED","sponsor":"University of Kansas Medical Center","startDate":"2019-08-29","conditions":"Heart Failure, Heart Diseases, Cardiovascular Diseases","enrollment":15},{"nctId":"NCT03727451","phase":"PHASE2","title":"A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis","status":"COMPLETED","sponsor":"Bellerophon","startDate":"2019-01-30","conditions":"Pulmonary Hypertension, Pulmonary Fibrosis, Sarcoidosis, Pulmonary","enrollment":17},{"nctId":"NCT04076241","phase":"NA","title":"Effects of Adding Yoga Respiratory Training to Osteopathic Manipulative Treatment in Pulmonary Arterial Hypertension","status":"COMPLETED","sponsor":"Istanbul University - Cerrahpasa","startDate":"2019-09-07","conditions":"Pulmonary Arterial Hypertension","enrollment":48},{"nctId":"NCT03079102","phase":"PHASE2","title":"Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest","status":"TERMINATED","sponsor":"Cameron Dezfulian","startDate":"2017-08-26","conditions":"Heart Arrest, Out-Of-Hospital","enrollment":57},{"nctId":"NCT04388683","phase":"PHASE2","title":"Inhaled Nitric Oxide for Preventing Progression in COVID-19","status":"TERMINATED","sponsor":"Tufts Medical Center","startDate":"2020-05-12","conditions":"COVID-19","enrollment":10},{"nctId":"NCT04383002","phase":"PHASE1","title":"High Dose Inhaled Nitric Oxide for COVID-19 (ICU Patients)","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2020-09-02","conditions":"COVID-19","enrollment":21},{"nctId":"NCT04292483","phase":"","title":"Pulmonary Capillary Recruitment in Fontan Patients","status":"UNKNOWN","sponsor":"Jewish General Hospital","startDate":"2020-06-11","conditions":"Congenital Heart Disease","enrollment":15},{"nctId":"NCT03331445","phase":"PHASE2","title":"Inhaled Gaseous Nitric Oxide (gNO) Antimicrobial Treatment of Difficult Bacterial and Viral Lung (COVID-19) Infections","status":"TERMINATED","sponsor":"Chris Miller","startDate":"2017-10-24","conditions":"Respiratory Tract Infections, Corona Virus Infection","enrollment":13},{"nctId":"NCT04443868","phase":"PHASE2","title":"Nitric Oxide Releasing Solution to Treat and Prevent Exacerbation of Mild COVID-19 Infection","status":"WITHDRAWN","sponsor":"Sanotize Research and Development corp.","startDate":"2021-01","conditions":"SARS-CoV Infection","enrollment":""},{"nctId":"NCT03748992","phase":"PHASE2","title":"A Proof of Concept Study of Inhaled Nitric Oxide for Adults With Pulmonary Non-Tuberculous Mycobacterial Infection","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2019-01-28","conditions":"Nontuberculous Mycobacterium Infection","enrollment":10},{"nctId":"NCT02498535","phase":"PHASE2","title":"Efficacy and Safety of Inhaled Nitric Oxide (NO) in Cystic Fibrosis (CF) Patients","status":"TERMINATED","sponsor":"Novoteris, LLC","startDate":"2017-02-22","conditions":"Cystic Fibrosis","enrollment":49},{"nctId":"NCT01220687","phase":"NA","title":"Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation","status":"COMPLETED","sponsor":"University of Oklahoma","startDate":"2011-04","conditions":"Respiratory Distress Syndrome in Premature Infants, Very Low Birth Weight Baby","enrollment":33},{"nctId":"NCT04398290","phase":"PHASE2","title":"iNOPulse for COVID-19","status":"WITHDRAWN","sponsor":"Roger Alvarez","startDate":"2020-12-01","conditions":"COVID-19, Hypoxemia, Hypoxemic Respiratory Failure","enrollment":""},{"nctId":"NCT04411160","phase":"","title":"Vitamin C Versus Nitric Oxide in Prolonged Ventilation","status":"COMPLETED","sponsor":"King Abdul Aziz Specialist Hospital","startDate":"2019-01-15","conditions":"ARDS","enrollment":60},{"nctId":"NCT04060979","phase":"PHASE2","title":"Evaluation of Two Doses of Nitric Oxide (NO) Given Intermittently Via Inhalation to Subjects With Bronchiolitis","status":"COMPLETED","sponsor":"Beyond Air Inc.","startDate":"2019-11-06","conditions":"Bronchiolitis Acute","enrollment":95},{"nctId":"NCT04290858","phase":"PHASE2","title":"Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID19 Infection","status":"WITHDRAWN","sponsor":"Xijing Hospital","startDate":"2020-03-01","conditions":"Coronavirus Infections, Pneumonia, Viral, Dyspnea","enrollment":""},{"nctId":"NCT03527381","phase":"PHASE1, PHASE2","title":"Nitric Oxide in Cardiopulmonary Bypass for Renal Protection in Cardiac Surgery","status":"COMPLETED","sponsor":"Nikolay Kamenshchikov","startDate":"2015-09-01","conditions":"Coronary Artery Disease, Heart Valve Diseases, Cardiomyopathies","enrollment":96},{"nctId":"NCT03873298","phase":"PHASE2","title":"Inhaled NO in IPF and COPD During 6 Minute Walk Test","status":"UNKNOWN","sponsor":"Rabin Medical Center","startDate":"2019-03-04","conditions":"COPD, IPF, Inhaled Nitric Oxide","enrollment":100},{"nctId":"NCT00626028","phase":"PHASE3","title":"Comparison of Inhaled Nitric Oxide and Oxygen in Participants Reactivity During Acute Pulmonary Vasodilator Testing","status":"COMPLETED","sponsor":"Mallinckrodt","startDate":"2004-09","conditions":"Idiopathic Pulmonary Arterial Hypertension, Cardiomyopathy","enrollment":136},{"nctId":"NCT00023296","phase":"PHASE1","title":"Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"2001-07-27","conditions":"Sickle Cell Anemia, Pulmonary Hypertension","enrollment":59},{"nctId":"NCT00570349","phase":"PHASE1, PHASE2","title":"Safety and Tolerability of Inhaled Nitric Oxide in Patients With Cystic Fibrosis","status":"COMPLETED","sponsor":"Mallinckrodt","startDate":"2004-07","conditions":"Cystic Fibrosis","enrollment":18},{"nctId":"NCT02871011","phase":"PHASE2","title":"Nitric Oxide Releasing Solution (NORS) Footbath to Treat Athlete's Foot","status":"COMPLETED","sponsor":"Nitric Solutions Inc.","startDate":"2016-08-13","conditions":"Tinea Pedis","enrollment":20},{"nctId":"NCT03053388","phase":"PHASE3","title":"Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently Via Inhalation to Subjects With Bronchiolitis","status":"COMPLETED","sponsor":"Beyond Air Inc.","startDate":"2017-03-05","conditions":"Bronchiolitis","enrollment":69},{"nctId":"NCT03208764","phase":"PHASE2","title":"Inhaled Nitric Oxide for Patients With MABSC","status":"COMPLETED","sponsor":"Beyond Air Inc.","startDate":"2017-07-24","conditions":"Mycobacterium Abscessus Infection","enrollment":9},{"nctId":"NCT03500783","phase":"PHASE1, PHASE2","title":"Nitric Oxide-mediated Cardioprotection During Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Tomsk National Research Medical Center of the Russian Academy of Sciences","startDate":"2015-05-15","conditions":"Coronary Artery Disease, Coronary Artery Bypass, Cardiopulmonary Bypass","enrollment":60},{"nctId":"NCT01467076","phase":"PHASE2","title":"Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF)","status":"TERMINATED","sponsor":"NICHD Neonatal Research Network","startDate":"2011-11","conditions":"Prematurity, Respiratory Insufficiency, Pulmonary Hypertension","enrollment":7},{"nctId":"NCT02345616","phase":"PHASE2","title":"Role of the Nitric Oxide (NO) in Pre-oxygenation Before Anesthetic Induction in Patients With a Pulmonary Hypertension in Cardiac Surgery. Pilot Study of Feasibility","status":"UNKNOWN","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2015-02","conditions":"Pulmonary Hypertension","enrollment":30},{"nctId":"NCT03066115","phase":"PHASE1","title":"Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation","status":"WITHDRAWN","sponsor":"University of Wisconsin, Madison","startDate":"2020-12-01","conditions":"Hypoxia, Hypercapnia","enrollment":""},{"nctId":"NCT02734953","phase":"PHASE2","title":"Effect of iNO on Invasively Derived Pulmonary Pressures in Patients With PAH","status":"COMPLETED","sponsor":"Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)","startDate":"2016-04","conditions":"Pulmonary Arterial Hypertension","enrollment":10},{"nctId":"NCT01095354","phase":"","title":"Investigation of Lung Ventilation Inhomogeneity in Pediatric Asthma","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2009-11","conditions":"Asthma","enrollment":49},{"nctId":"NCT01461343","phase":"NA","title":"Evaluation of Pulmonary Perfusion Heterogeneity and Compliance in Patients With Pulmonary Hypertension Using Positron Emission Tomography Imaging","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2013-02","conditions":"Pulmonary Arterial Hypertension","enrollment":16},{"nctId":"NCT01881347","phase":"NA","title":"Effects of Resveratrol on Endothelial Function in Type 2 Diabetes Mellitus","status":"COMPLETED","sponsor":"Boston University","startDate":"2013-01-01","conditions":"Diabetes Mellitus","enrollment":54},{"nctId":"NCT02551107","phase":"NA","title":"Infant Nasal Nitric Oxide Levels in Congenital Heart Disease","status":"TERMINATED","sponsor":"University of Alberta","startDate":"2015-12","conditions":"Congenital Heart Disease","enrollment":67},{"nctId":"NCT00016523","phase":"PHASE3","title":"Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure","status":"TERMINATED","sponsor":"NICHD Neonatal Research Network","startDate":"2001-01","conditions":"Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age","enrollment":420},{"nctId":"NCT00005776","phase":"PHASE3","title":"Inhaled Nitric Oxide Study for Respiratory Failure in Newborns","status":"TERMINATED","sponsor":"NICHD Neonatal Research Network","startDate":"1995-10","conditions":"Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome","enrollment":235},{"nctId":"NCT00005773","phase":"PHASE3","title":"Early Inhaled Nitric Oxide for Respiratory Failure in Newborns","status":"TERMINATED","sponsor":"NICHD Neonatal Research Network","startDate":"1998-08","conditions":"Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome","enrollment":302},{"nctId":"NCT00308633","phase":"","title":"Endothelial Progenitor Cells and Nitric Oxide in Cardiac Rehabilitation Program Participants","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"2006-03-23","conditions":"Coronary Artery Disease (CAD)","enrollment":55},{"nctId":"NCT02221466","phase":"","title":"Measurement of Endothelial Function With Peripheral Arterial Tonometry in Patients Undergoing Hyperbaric Oxygen Therapy","status":"COMPLETED","sponsor":"Ole Hyldegaard","startDate":"2014-02","conditions":"Diabetic Peripheral Vascular Disease","enrollment":45},{"nctId":"NCT03006211","phase":"NA","title":"The Effects of Nitrogen Protoxide and Oxygen on Corneal Endothelial in Pediatric Patients","status":"COMPLETED","sponsor":"Inonu University","startDate":"2016-12","conditions":"Cornea, Anesthesia; Reaction","enrollment":40},{"nctId":"NCT00390065","phase":"PHASE4","title":"Follow-Up at 6 Years of a Cohort of Children Born Very Prematurely","status":"COMPLETED","sponsor":"Maternite Regionale Universitaire","startDate":"2006-10","conditions":"Premature Birth","enrollment":108},{"nctId":"NCT00848302","phase":"EARLY_PHASE1","title":"Endothelial Function in Human Arteries","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2009-09","conditions":"Endothelial Dysfunction","enrollment":25},{"nctId":"NCT02220023","phase":"EARLY_PHASE1","title":"Dynamic Assessment of Right Ventricular Function With Inhaled Nitric Oxide During Cardiac MRI","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2014-07","conditions":"Pulmonary Vascular Disorder","enrollment":17},{"nctId":"NCT00570245","phase":"PHASE2","title":"Safety and Efficacy Study of Nitric Oxide in Patients Going Through Lung Transplantation","status":"COMPLETED","sponsor":"Mallinckrodt","startDate":"2005-04","conditions":"Lung Transplantation","enrollment":49},{"nctId":"NCT00041548","phase":"PHASE1, PHASE2","title":"Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation","status":"TERMINATED","sponsor":"Mallinckrodt","startDate":"2002-05","conditions":"Lung Disease, Hypoxemia, Respiratory Acidosis","enrollment":7},{"nctId":"NCT02617680","phase":"NA","title":"Factors Affecting the Effective End-tidal Concentration of Desflurane Anaesthesia","status":"COMPLETED","sponsor":"University Hospital Hradec Kralove","startDate":"2015-02","conditions":"General Anesthetic Drug Adverse Reaction","enrollment":80},{"nctId":"NCT01921426","phase":"PHASE1","title":"A Phase 1 Dose Escalation Study of GC4419 in Combination With Chemoradiation for Squamous Cell Cancer of the Head & Neck","status":"COMPLETED","sponsor":"Galera Therapeutics, Inc.","startDate":"2013-08","conditions":"Squamous Cell Carcinoma of the Oral Cavity, Squamous Cell Carcinoma of the Oropharynx","enrollment":30},{"nctId":"NCT01265888","phase":"PHASE2","title":"Study in Subjects With PAH and PH Secondary to IPF Using Inhaled GeNOsyl.","status":"COMPLETED","sponsor":"Geno LLC","startDate":"2011-03","conditions":"Pulmonary Arterial Hypertension, Idiopathic Pulmonary Fibrosis","enrollment":31},{"nctId":"NCT02051504","phase":"","title":"Muscle Oxygenation, Type 1 Diabetes, and Glycated Hemoglobin","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2010-03","conditions":"Type 1 Diabetes","enrollment":79},{"nctId":"NCT02821156","phase":"","title":"Study on the Use of Inhaled NO (iNO)","status":"COMPLETED","sponsor":"Air Liquide Santé International","startDate":"2014-09","conditions":"Pulmonary Hypertension","enrollment":239},{"nctId":"NCT01958944","phase":"PHASE1, PHASE2","title":"Evaluation of the Safety and Tolerability of Inhaled Nitric Oxide to Subjects With Cystic Fibrosis","status":"COMPLETED","sponsor":"Beyond Air Inc.","startDate":"2013-12","conditions":"Cystic Fibrosis","enrollment":9},{"nctId":"NCT01768884","phase":"PHASE1, PHASE2","title":"Evaluation of the Safety and Tolerability of Nitric Oxide (NO) Via Inhalation to Subjects With Bronchiolitis","status":"COMPLETED","sponsor":"Beyond Air Inc.","startDate":"2013-01","conditions":"Bronchiolitis","enrollment":43},{"nctId":"NCT01485237","phase":"","title":"Severe Pandemic H1N1 Infection in ICU: Comparative Resource Utilization","status":"COMPLETED","sponsor":"University of Manitoba","startDate":"2009-10","conditions":"Novel H1N1 Influenzal Acute Respiratory Infection","enrollment":400},{"nctId":"NCT00585013","phase":"PHASE1, PHASE2","title":"Inhaled NO as an Anti-inflammatory and Anti-reperfusion Agent in Infants and Children Undergoing Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2008-01","conditions":"Congenital Heart Disease","enrollment":17},{"nctId":"NCT00159510","phase":"PHASE1","title":"Studies of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome","status":"TERMINATED","sponsor":"Northern State Medical University","startDate":"2004-04","conditions":"Sepsis","enrollment":28},{"nctId":"NCT02368171","phase":"","title":"Role of Heme-oxygenase (HO) and Nitric Oxide (NO) Pathway in Patients With Obstructive Sleep Apnea (OSA) and Pulmonary Hypertension (PH)","status":"UNKNOWN","sponsor":"Southern California Institute for Research and Education","startDate":"2015-03","conditions":"Obstructive Sleep Apnea, Pulmonary Hypertension","enrollment":60},{"nctId":"NCT00808171","phase":"PHASE4","title":"Evaluation of the Analgesy With Emla and/or Nitrous Oxide in Pediatric Patients for Lumbar Puncture","status":"COMPLETED","sponsor":"Federal University of Minas Gerais","startDate":"2009-02","conditions":"Leukemia, Non Hodgkin Lymphoma","enrollment":52},{"nctId":"NCT01347957","phase":"PHASE1, PHASE2","title":"Safety and Efficacy of Nitric Oxide Gel in Promoting Hair Growth in Male Human Subjects With Androgenetic Alopecia","status":"UNKNOWN","sponsor":"China Medical University Hospital","startDate":"2012-08","conditions":"Alopecia Androgenica","enrollment":60},{"nctId":"NCT00893880","phase":"PHASE2","title":"A Dose Response Trial to Evaluate Clinical and Mycological Effect of Nitric Oxide in Subjects With Tinea Pedis","status":"COMPLETED","sponsor":"Nitric BioTherapeutics, Inc","startDate":"2009-06","conditions":"Tinea Pedis","enrollment":92},{"nctId":"NCT01351493","phase":"PHASE1, PHASE2","title":"Study on the Safety and Efficacy of Nitric Oxide Gel in Subjects With Pressure Sore","status":"UNKNOWN","sponsor":"China Medical University Hospital","startDate":"2012-07","conditions":"Pressure Ulcer","enrollment":40},{"nctId":"NCT00004500","phase":"PHASE3","title":"Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome","status":"TERMINATED","sponsor":"Windtree Therapeutics","startDate":"2000-03","conditions":"Meconium Aspiration","enrollment":69}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":559,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Inhaled Nitric Oxide, Oxygen"],"phase":"phase_3","status":"active","brandName":"Nitric Oxide plus Oxygen","genericName":"Nitric Oxide plus Oxygen","companyName":"Mallinckrodt","companyId":"mallinckrodt","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nitric oxide, in combination with oxygen, is being studied as a treatment for various conditions, including Squamous Cell Carcinoma of the Oral Cavity, Squamous Cell Carcinoma of the Oropharynx, and Pulmonary Arterial Hypertension. Nitric oxide is a soluble guanylate cyclase activator, a small molecule that works by activating this enzyme.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}