{"id":"nitric-oxide-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or erythema"},{"rate":null,"effect":"Headache (if systemic absorption occurs)"}]},"_chembl":{"chemblId":"CHEMBL1200689","moleculeType":"Small molecule","molecularWeight":"30.01"},"_dailymed":{"setId":"1ca5d57d-7cf0-4b9a-afa0-767dca99864d","title":"VASCUFLOW (MELATONIN, L-ARGININE, L-CITRULLINE, UBIDECARENONUM, SQUALENE, CALCAREA CARBONICA, CHOLESTERINUM, COUMARINUM, FORMALINUM, GELSEMIUM SEMPERVIRENS, ALPHA-LIPOICUM ACIDUM, MERCURIUS CORROSIVUS, PLUMBUM METALLICUM, PANTOTHENIC ACID, GLONOINUM, LYCOPODIUM CLAVATUM, PHOSPHORUS, BERBERIS VULGARIS, RED YEAST RICE, NITRIC OXIDE, PROTEUS (MORGANI), RHUS TOX) LIQUID [DESERET BIOLOGICALS, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nitric oxide (NO) is a signaling molecule that activates guanylate cyclase, increasing cyclic GMP levels and causing smooth muscle relaxation and vasodilation. When applied topically as a gel, it increases local blood perfusion and oxygen delivery to the affected area, promoting angiogenesis and accelerating tissue repair. This mechanism is particularly useful in chronic wounds and ischemic conditions where blood flow is compromised.","oneSentence":"Nitric oxide gel delivers nitric oxide directly to tissue to promote vasodilation, improve blood flow, and enhance wound healing.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:22:39.537Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic wounds"},{"name":"Diabetic foot ulcers"},{"name":"Pressure ulcers"}]},"trialDetails":[{"nctId":"NCT07021495","phase":"","title":"SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY)","status":"RECRUITING","sponsor":"Leiden University Medical Center","startDate":"2025-07-29","conditions":"Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS), Psoriasis (PsO)","enrollment":840},{"nctId":"NCT06859554","phase":"PHASE4","title":"Efficacy and Safety of GTN vs. Nifedipine in Acute Anal Fissure: A Clinical Trial","status":"COMPLETED","sponsor":"Hafiz Muhammad Hamza","startDate":"2025-03-17","conditions":"Acute Anal Fissure, Anal Pain, Anorectal Disorders","enrollment":110},{"nctId":"NCT06116045","phase":"PHASE2","title":"Evaluation of the Efficacy, Safety and Tolerability of BZ371A in Women with Sexual Arousal Disorder","status":"RECRUITING","sponsor":"Biozeus Biopharmaceutical S.A.","startDate":"2024-10-01","conditions":"Female Sexual Arousal Disorder, Female Sexual Dysfunction","enrollment":30},{"nctId":"NCT05787925","phase":"NA","title":"Adjunctive Oral Systemic Vitamin E Therapy on Salivary Nitric Oxide Level in Patients With Erosive Oral Lichen Planus","status":"COMPLETED","sponsor":"Hams Hamed Abdelrahman","startDate":"2022-10-20","conditions":"Lichen Planus","enrollment":52},{"nctId":"NCT05616455","phase":"PHASE4","title":"Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial","status":"COMPLETED","sponsor":"Treviso Regional Hospital","startDate":"2021-10-01","conditions":"Anal Fissure Chronic, Anal Fissure","enrollment":120},{"nctId":"NCT01983085","phase":"PHASE2","title":"Nitric Oxide Generating Gel Dressing in Patients With Superficial Partial Thickness Wounds","status":"TERMINATED","sponsor":"Edixomed Ltd","startDate":"2013-09","conditions":"Superficial Partial Thickness Burn, Skin Graft; Complications","enrollment":13},{"nctId":"NCT01556698","phase":"PHASE1, PHASE2","title":"Study of NVN1000 Topical Gel and Topical Gel Vehicle in the Treatment of Moderate to Severe Acne Vulgaris","status":"COMPLETED","sponsor":"Novan, Inc.","startDate":"2011-07","conditions":"Acne Vulgaris, Acne","enrollment":70},{"nctId":"NCT01982565","phase":"PHASE1, PHASE2","title":"Nitric Oxide Generating Gel Dressing in Patients With Diabetic Foot Ulcers","status":"COMPLETED","sponsor":"Edixomed Ltd","startDate":"2013-06","conditions":"Diabetic Foot Ulcer","enrollment":130},{"nctId":"NCT02488642","phase":"PHASE4","title":"Medical Management of Late Intrauterine Death.","status":"COMPLETED","sponsor":"National Institute of Perinatology","startDate":"2008-05","conditions":"Cervical Pregnancy, Maternal Care for Late Fetal Death","enrollment":60},{"nctId":"NCT01633086","phase":"PHASE2","title":"A Study on the Safety and Efficacy of Nitric Oxide Gel in Subjects With Painful Diabetic Neuropathy","status":"COMPLETED","sponsor":"China Medical University Hospital","startDate":"2012-07","conditions":"Neuropathic Pain","enrollment":24},{"nctId":"NCT01347957","phase":"PHASE1, PHASE2","title":"Safety and Efficacy of Nitric Oxide Gel in Promoting Hair Growth in Male Human Subjects With Androgenetic Alopecia","status":"UNKNOWN","sponsor":"China Medical University Hospital","startDate":"2012-08","conditions":"Alopecia Androgenica","enrollment":60},{"nctId":"NCT01351493","phase":"PHASE1, PHASE2","title":"Study on the Safety and Efficacy of Nitric Oxide Gel in Subjects With Pressure Sore","status":"UNKNOWN","sponsor":"China Medical University Hospital","startDate":"2012-07","conditions":"Pressure Ulcer","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"nitric oxide gel","genericName":"nitric oxide gel","companyName":"China Medical University Hospital","companyId":"china-medical-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nitric oxide gel delivers nitric oxide directly to tissue to promote vasodilation, improve blood flow, and enhance wound healing. Used for Chronic wounds, Diabetic foot ulcers, Pressure ulcers.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}