{"id":"nitrendipine-atenolol","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Flushing"}]},"_chembl":{"chemblId":"CHEMBL24","moleculeType":"Small molecule","molecularWeight":"266.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nitrendipine is a dihydropyridine calcium channel blocker that inhibits L-type calcium channels in vascular smooth muscle, causing vasodilation and reduced peripheral vascular resistance. Atenolol is a selective beta-1 adrenergic antagonist that decreases heart rate, contractility, and blood pressure. The combination provides complementary antihypertensive effects through different mechanisms.","oneSentence":"This combination drug reduces blood pressure by blocking calcium channels (nitrendipine) to relax blood vessels and blocking beta-adrenergic receptors (atenolol) to reduce heart rate and cardiac output.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:57:16.461Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT04931108","phase":"PHASE4","title":"The Effect of Nitrendipine/Atenolol Combination on Blood Pressure Variability.","status":"UNKNOWN","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2021-09-27","conditions":"Hypertension","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Nitrendipine and Atenolol Tablets"],"phase":"marketed","status":"active","brandName":"Nitrendipine/Atenolol","genericName":"Nitrendipine/Atenolol","companyName":"Shanghai Jiao Tong University School of Medicine","companyId":"shanghai-jiao-tong-university-school-of-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination drug reduces blood pressure by blocking calcium channels (nitrendipine) to relax blood vessels and blocking beta-adrenergic receptors (atenolol) to reduce heart rate and cardiac output. Used for Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}