{"id":"nimetazepam","rwe":[{"pmid":"38487758","year":"2024","title":"Overdrive Pacing for Persistent Torsades de Pointes and Pulseless Ventricular Tachycardia.","finding":"","journal":"Journal of acute medicine","studyType":"Clinical Study"},{"pmid":"37598646","year":"2023","title":"Quantification of nimetazepam and its metabolite in human hair samples using liquid chromatography-tandem mass spectrometry: Case report.","finding":"","journal":"Legal medicine (Tokyo, Japan)","studyType":"Clinical Study"},{"pmid":"36273275","year":"2023","title":"Detection and discrimination of sedative-hypnotics in spiked beverage dry residues using attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy combined with chemometrics.","finding":"","journal":"Journal of forensic sciences","studyType":"Clinical Study"},{"pmid":"35616477","year":"2022","title":"Vortex-assisted dispersive liquid-liquid microextraction-gas chromatography (VADLLME-GC) determination of residual ketamine, nimetazepam, and xylazine from drug-spiked beverages appearing in liquid, droplet, and dry forms.","finding":"","journal":"Journal of forensic sciences","studyType":"Clinical Study"},{"pmid":"33575738","year":"2022","title":"Simultaneous Quantitation of Seven Phenethylamine-Type Drugs in Forensic Blood and Urine Samples by UHPLC-MS-MS.","finding":"","journal":"Journal of analytical toxicology","studyType":"Clinical Study"}],"tags":[{"label":"nimetazepam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05CD15","category":"atc"},{"label":"Active","category":"status"},{"label":"Insomnia","category":"indication"},{"label":"Anti-Anxiety Agents","category":"pharmacology"},{"label":"Anticonvulsants","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"GABA Agents","category":"pharmacology"},{"label":"GABA Modulators","category":"pharmacology"},{"label":"Hypnotics and Sedatives","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"nimetazam","offLabel":[],"synonyms":["nimetazepam","methylnitrazepam","nimetazam"],"timeline":[],"approvals":[],"brandName":"Nimetazam","ecosystem":[{"indication":"Insomnia","otherDrugs":[{"name":"amobarbital","slug":"amobarbital","company":""},{"name":"choline","slug":"choline","company":""},{"name":"daridorexant","slug":"daridorexant","company":"Idorsia Pharmaceuticals Ltd"},{"name":"diphenhydramine","slug":"diphenhydramine","company":"Mcneil Cons"}],"globalPrevalence":750000000}],"mechanism":{"modality":"Small Molecule","drugClass":"nimetazepam","explanation":"Imagine your brain is like a busy city with lots of noise and activity. GABA is like a traffic cop that helps to slow down the traffic and calm things down. Nimetazepam helps GABA do its job more effectively, making it easier to fall asleep and stay asleep.","oneSentence":"Nimetazepam works by enhancing the activity of the neurotransmitter GABA, which helps to calm the brain and induce sleep.","technicalDetail":"Nimetazepam acts as a positive allosteric modulator of the GABA_A receptor, increasing the frequency of chloride channel opening and resulting in hyperpolarization of the neuronal membrane, which leads to sedative and hypnotic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1936","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NIMETAZEPAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:40:06.049292","biosimilars":[],"competitors":[{"drugName":"flurazepam","drugSlug":"flurazepam","fdaApproval":"1970-04-07","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"estazolam","drugSlug":"estazolam","fdaApproval":"1990-12-26","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"triazolam","drugSlug":"triazolam","fdaApproval":"1982-11-15","genericCount":6,"patentStatus":"Off-patent — generic 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sciences"},{"date":"2022 Mar 21","pmid":"33575738","title":"Simultaneous Quantitation of Seven Phenethylamine-Type Drugs in Forensic Blood and Urine Samples by UHPLC-MS-MS.","journal":"Journal of analytical toxicology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nimetazam is a small molecule. It is also known by other names, including ERIMIN, NIMETAZEPAM, S 1530, and S-1530.","enrichmentLevel":3,"visitCount":3,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}