{"id":"nilotinib-imatinib","safety":{"commonSideEffects":[{"rate":"40-50","effect":"Nausea"},{"rate":"20-30","effect":"Vomiting"},{"rate":"30-40","effect":"Diarrhea"},{"rate":"20-30","effect":"Abdominal pain"},{"rate":"20-30","effect":"Rash"},{"rate":"20-30","effect":"Fatigue"},{"rate":"15-25","effect":"Headache"},{"rate":"20-30","effect":"Muscle cramps"},{"rate":"30-50","effect":"Myelosuppression (anemia, thrombocytopenia, neutropenia)"},{"rate":"10-20","effect":"Elevated liver enzymes"}]},"_chembl":{"chemblId":"CHEMBL255863","moleculeType":"Small molecule","molecularWeight":"529.53"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Both drugs inhibit the constitutively active BCR-ABL fusion protein that drives chronic myeloid leukemia (CML) by binding to the ATP-binding pocket of the kinase domain. Nilotinib is a second-generation inhibitor with improved potency and selectivity compared to imatinib, while imatinib was the first-in-class BCR-ABL inhibitor. Both also inhibit KIT and PDGFRA, making them effective in gastrointestinal stromal tumors (GISTs).","oneSentence":"Nilotinib and Imatinib are tyrosine kinase inhibitors that block BCR-ABL and other kinase signaling pathways to suppress abnormal cell proliferation in chronic myeloid leukemia and gastrointestinal stromal tumors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:23:02.680Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic myeloid leukemia (CML), chronic phase"},{"name":"Chronic myeloid leukemia (CML), accelerated phase and blast crisis"},{"name":"Gastrointestinal stromal tumor (GIST), KIT-positive"}]},"trialDetails":[{"nctId":"NCT07493408","phase":"PHASE2","title":"Asciminib & Standard-of-Care Integration in Maintenance Therapy for POST Allogeneic Stem Cell Transplant (Allo-HSCT) of Patient With Ph+ B-ALL or Blastic Transformed CML","status":"NOT_YET_RECRUITING","sponsor":"The University of Hong Kong","startDate":"2026-03-30","conditions":"Ph+ Acute Lymphoblastic Leukemia (Ph+ALL), Blastic Transformation of Chronic Myeloid Leukemia, Philadelphia Chromosome-positive B-cell Acute Lymphoblastic Leukemia (Ph+ B-ALL)","enrollment":45},{"nctId":"NCT05143840","phase":"PHASE2","title":"Asciminib as Initial Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase","status":"RECRUITING","sponsor":"Augusta University","startDate":"2022-04-22","conditions":"Chronic Myeloid Leukemia, Chronic Phase, Adult CML, Leukemia, Myeloid","enrollment":100},{"nctId":"NCT04971226","phase":"PHASE3","title":"A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP","status":"ACTIVE_NOT_RECRUITING","sponsor":"Novartis Pharmaceuticals","startDate":"2021-10-06","conditions":"Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive","enrollment":406},{"nctId":"NCT01746836","phase":"PHASE2","title":"Ponatinib Hydrochloride as Second Line Therapy in Treating Patients With Chronic Myeloid Leukemia in Chronic Phase Resistant or Intolerant to Imatinib Mesylate, Dasatinib, or Nilotinib","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2013-01-17","conditions":"Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia, Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive","enrollment":50},{"nctId":"NCT04877522","phase":"PHASE4","title":"Asciminib Roll-over Study","status":"RECRUITING","sponsor":"Novartis Pharmaceuticals","startDate":"2022-08-30","conditions":"Chronic Myelogenous Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive","enrollment":347},{"nctId":"NCT03516279","phase":"PHASE2","title":"Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"ECOG-ACRIN Cancer Research Group","startDate":"2019-06-26","conditions":"Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Minimal Residual Disease","enrollment":40},{"nctId":"NCT07413263","phase":"","title":"Impact of Tyrosine Kinase Inhibitors on Glucose Level and Lipid Metabolism in Chronic Myeloid Leukemia Patients","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-05-01","conditions":"Chronic Myeloid Leukemia","enrollment":75},{"nctId":"NCT03610971","phase":"PHASE2","title":"Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase Inhibitors","status":"ACTIVE_NOT_RECRUITING","sponsor":"H. 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