{"id":"nikethamide","rwe":[{"pmid":"40900842","year":"2025","title":"Preventive and therapeutic effects of magnesium sulfate on nikethamide-induced seizures: Implications for COVID-19 treatment.","finding":"","journal":"World journal of methodology","studyType":"Clinical Study"},{"pmid":"39613826","year":"2024","title":"Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"38206578","year":"2024","title":"Wearable Plasmonic Sensors Engineered via Active-Site Maximization of TiVC MXene for Universal Physiological Monitoring at the Molecular Level.","finding":"","journal":"ACS sensors","studyType":"Clinical Study"},{"pmid":"38012222","year":"2023","title":"Metal-organic framework boosts heterogeneous electron donor-acceptor catalysis.","finding":"","journal":"Nature communications","studyType":"Clinical Study"},{"pmid":"37909653","year":"2024","title":"Drug-induced hypoglycemia: a disproportionality analysis of the FAERS database.","finding":"","journal":"Expert opinion on drug safety","studyType":"Clinical Study"}],"tags":[{"label":"nikethamide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R07AB02","category":"atc"},{"label":"Active","category":"status"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Stimulants","category":"pharmacology"},{"label":"Convulsants","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"niamine","offLabel":[],"synonyms":["nikethamide","anacardone","anacordone","niamine","nicamide","nicetamide","nicethamide","nicorine","nicotinic acid diethylamide","carbamidal","pyricardyl"],"timeline":[],"approvals":[],"brandName":"Niamine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"nikethamide","explanation":"Think of it like a wake-up call for your brain. Niamine helps increase the activity of certain chemicals in the brain that help you feel more alert and awake. This can be helpful in situations where you need to stay awake and focused, such as during long periods of work or study.","oneSentence":"Niamine works by stimulating the central nervous system, which can help increase alertness and wakefulness.","technicalDetail":"Nikethamide is a central nervous system stimulant that acts as a GABA receptor antagonist, increasing the activity of excitatory neurotransmitters and decreasing the activity of inhibitory neurotransmitters, leading to increased alertness and wakefulness."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3383","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NIKETHAMIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:58:01.825958","biosimilars":[],"competitors":[{"drugName":"doxapram","drugSlug":"doxapram","fdaApproval":"1965-06-23","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"nikethamide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"doxapram","brandName":"doxapram","genericName":"doxapram","approvalYear":"1965","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000167328","NDDF":"001381","UNII":"368IVD6M32","CHEBI":"CHEBI:134814","INN_ID":"403","RXNORM":"7424","UMLSCUI":"C0028089","ChEMBL_ID":"CHEMBL2104607","KEGG_DRUG":"D07408","DRUGBANK_ID":"DB13655","PUBCHEM_CID":"5497","SNOMEDCT_US":"387591002","MESH_DESCRIPTOR_UI":"D009552"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":262,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"R07AB02","allCodes":["R07AB02","R07AB52"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Dec 20","pmid":"40900842","title":"Preventive and therapeutic effects of magnesium sulfate on nikethamide-induced seizures: Implications for COVID-19 treatment.","journal":"World journal of methodology"},{"date":"2024 Nov 29","pmid":"39613826","title":"Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system.","journal":"Scientific reports"},{"date":"2024 Jan 26","pmid":"38206578","title":"Wearable Plasmonic Sensors Engineered via Active-Site Maximization of TiVC MXene for Universal Physiological Monitoring at the Molecular Level.","journal":"ACS sensors"},{"date":"2023 Nov 27","pmid":"38012222","title":"Metal-organic framework boosts heterogeneous electron donor-acceptor catalysis.","journal":"Nature communications"},{"date":"2024 Aug","pmid":"37909653","title":"Drug-induced hypoglycemia: a disproportionality analysis of the FAERS database.","journal":"Expert opinion on drug safety"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Niamine, also known as nikethamide, is a small molecule drug in the nikethamide class. Its exact target is unknown, but it is believed to work by stimulating the central nervous system. Niamine is not FDA-approved for any indications, and its commercial status is unclear. As a result, there is limited information available on its safety profile. Further research is needed to fully understand its effects and potential uses.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}