{"id":"nighttime-dosing-of-mirabegron","safety":{"commonSideEffects":[{"rate":"1-3","effect":"Hypertension"},{"rate":"2-4","effect":"Headache"},{"rate":"2-3","effect":"Nasopharyngitis"},{"rate":"1-2","effect":"Tachycardia"},{"rate":"1-2","effect":"Urinary tract infection"}]},"_chembl":{"chemblId":"CHEMBL2095212","moleculeType":"Small molecule","molecularWeight":"396.52"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mirabegron activates beta-3 adrenergic receptors on the smooth muscle of the bladder detrusor, causing relaxation and increased bladder capacity during the storage phase of the micturition cycle. Unlike anticholinergic agents, it does not block muscarinic receptors, resulting in a different safety and tolerability profile. Nighttime dosing may be used to optimize symptom control during sleep hours.","oneSentence":"Mirabegron is a beta-3 adrenergic receptor agonist that relaxes the detrusor muscle in the bladder to increase urine storage capacity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:14.121Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Overactive bladder with symptoms of urge incontinence, urgency, and urinary frequency"}]},"trialDetails":[{"nctId":"NCT03251300","phase":"PHASE4","title":"Mirabegron for Female OAB Patients: Comparison of Daytime and Nighttime Dosing","status":"UNKNOWN","sponsor":"Far Eastern Memorial Hospital","startDate":"2017-08-01","conditions":"Overactive Bladder Syndrome","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"nighttime dosing of mirabegron","genericName":"nighttime dosing of mirabegron","companyName":"Far Eastern Memorial Hospital","companyId":"far-eastern-memorial-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mirabegron is a beta-3 adrenergic receptor agonist that relaxes the detrusor muscle in the bladder to increase urine storage capacity. Used for Overactive bladder with symptoms of urge incontinence, urgency, and urinary frequency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}