{"id":"nifurtoinol","rwe":[{"pmid":"10071389","year":"1998","title":"Electron spin resonance detection of radiosterilization of pharmaceuticals: application to four nitrofurans.","finding":"","journal":"The Analyst","studyType":"Clinical Study"},{"pmid":"3371877","year":"1988","title":"Hepatic injury associated with the use of nitrofurans: a clinicopathological study of 52 reported cases.","finding":"","journal":"Hepatology (Baltimore, Md.)","studyType":"Clinical Study"},{"pmid":"6624626","year":"1983","title":"[Prolonged-action nifurtoinol in urinary infections. Comparative study].","finding":"","journal":"Acta urologica Belgica","studyType":"Clinical Study"}],"tags":[{"label":"nifurtoinol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01XE02","category":"atc"},{"label":"Active","category":"status"},{"label":"Urinary tract infectious disease","category":"indication"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Infective Agents, Urinary","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"urfadine","offLabel":[],"synonyms":["nifurtoinol","hydroxymethylnitrofurantoin","urfadine"],"timeline":[],"approvals":[],"brandName":"Urfadine","ecosystem":[{"indication":"Urinary tract infectious disease","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"acetohydroxamic acid","slug":"acetohydroxamic-acid","company":"Mission Pharma"},{"name":"alatrofloxacin","slug":"alatrofloxacin","company":"Pfizer"},{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"nifurtoinol","explanation":"Imagine your body's cells are like a city, and bacteria are like unwanted visitors. Urfadine helps to stop the bacteria from multiplying and taking over the city by interfering with their ability to make copies of themselves.","oneSentence":"Urfadine works by inhibiting the growth and replication of bacteria in the urinary tract.","technicalDetail":"Nifurtoinol compounds, such as Urfadine, exert their antibacterial effects by targeting the bacterial cell membrane and disrupting its function, ultimately leading to bacterial cell death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1930","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NIFURTOINOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:57:58.190966","biosimilars":[],"competitors":[{"drugName":"nitrofurantoin","drugSlug":"nitrofurantoin","fdaApproval":"1953-02-06","genericCount":15,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"nifurtoinol","indications":{"approved":[{"name":"Urinary tract infectious disease","source":"DrugCentral","snomedId":68566005,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nitrofurantoin","brandName":"nitrofurantoin","genericName":"nitrofurantoin","approvalYear":"1953","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005814","UNII":"980688H13O","CHEBI":"CHEBI:88255","INN_ID":"3997","UMLSCUI":"C3266849","ChEMBL_ID":"CHEMBL1697763","KEGG_DRUG":"D07243","DRUGBANK_ID":"DB13730","PUBCHEM_CID":"9571062","SNOMEDCT_US":"713437001","IUPHAR_LIGAND_ID":"12346","MESH_SUPPLEMENTAL_RECORD_UI":"C002848"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01XE02","allCodes":["J01XE02"]},"biosimilarFilings":[],"recentPublications":[{"date":"1998 Aug","pmid":"10071389","title":"Electron spin resonance detection of radiosterilization of pharmaceuticals: application to four nitrofurans.","journal":"The Analyst"},{"date":"1988 May-Jun","pmid":"3371877","title":"Hepatic injury associated with the use of nitrofurans: a clinicopathological study of 52 reported cases.","journal":"Hepatology (Baltimore, Md.)"},{"date":"1983","pmid":"6624626","title":"[Prolonged-action nifurtoinol in urinary infections. Comparative study].","journal":"Acta urologica Belgica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Urfadine (NIFURTOINOL) is a small molecule drug in the nifurtoinol class, used to treat urinary tract infectious diseases. Its exact target is unknown, but it is believed to work by inhibiting bacterial growth and replication. Urfadine's commercial status is unclear, and it may be patented or available as a generic medication. Key safety considerations include potential side effects and interactions with other medications. Further research is needed to fully understand its pharmacokinetics and safety profile.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}