{"id":"nifurpirinol","rwe":[{"pmid":"40295334","year":"2025","title":"Pancreatic exocrine damage induces beta cell stress in zebrafish larvae.","finding":"","journal":"Diabetologia","studyType":"Clinical Study"},{"pmid":"38991006","year":"2024","title":"Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight.","finding":"","journal":"American journal of physiology. Renal physiology","studyType":"Clinical Study"},{"pmid":"38515656","year":"2024","title":"Determination of nitrofuran metabolites and nifurpirinol in animal tissues and eggs by ultra-high performance liquid chromatography-tandem mass spectrometry validated according to Regulation (EU) 2021/808.","finding":"","journal":"Heliyon","studyType":"Clinical Study"},{"pmid":"37668916","year":"2024","title":"Selective Cell Ablation Using an Improved Prodrug-Converting Nitroreductase.","finding":"","journal":"Methods in molecular biology (Clifton, N.J.)","studyType":"Clinical Study"},{"pmid":"34593884","year":"2021","title":"Collagen fibers provide guidance cues for capillary regrowth during regenerative angiogenesis in zebrafish.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"}],"tags":[{"label":"nifurpirinol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"furanace","offLabel":[],"synonyms":["nifurpirinol","furanace","furpirinol","furpyrinol","prefuran"],"timeline":[],"approvals":[],"brandName":"Furanace","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"nifurpirinol","explanation":"Imagine your body's cells are like a factory that makes new parts. Nifurpirinol is like a machine that breaks down the factory's blueprint, making it impossible for the microorganisms to make new parts and eventually killing them.","oneSentence":"Nifurpirinol works by interfering with the synthesis of DNA and RNA in microorganisms, ultimately leading to their death.","technicalDetail":"Nifurpirinol exerts its antimicrobial effects by inhibiting the activity of dihydrofolate reductase, an enzyme essential for the synthesis of tetrahydrofolate, a precursor to thymidylate and purines, which are critical for DNA and RNA synthesis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3382","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NIFURPIRINOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:57:52.305628","biosimilars":[],"competitors":[],"genericName":"nifurpirinol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"7O5A98XY8U","CHEBI":"CHEBI:135000","INN_ID":"2716","UMLSCUI":"C0068743","ChEMBL_ID":"CHEMBL2104627","KEGG_DRUG":"D02513","DRUGBANK_ID":"DB11436","PUBCHEM_CID":"6436061","SNOMEDCT_US":"96166003","MESH_SUPPLEMENTAL_RECORD_UI":"C004562"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":17,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Aug","pmid":"40295334","title":"Pancreatic exocrine damage induces beta cell stress in zebrafish larvae.","journal":"Diabetologia"},{"date":"2024 Sep 1","pmid":"38991006","title":"Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight.","journal":"American journal of physiology. Renal physiology"},{"date":"2024 Mar 30","pmid":"38515656","title":"Determination of nitrofuran metabolites and nifurpirinol in animal tissues and eggs by ultra-high performance liquid chromatography-tandem mass spectrometry validated according to Regulation (EU) 2021/808.","journal":"Heliyon"},{"date":"2024","pmid":"37668916","title":"Selective Cell Ablation Using an Improved Prodrug-Converting Nitroreductase.","journal":"Methods in molecular biology (Clifton, N.J.)"},{"date":"2021 Sep 30","pmid":"34593884","title":"Collagen fibers provide guidance cues for capillary regrowth during regenerative angiogenesis in zebrafish.","journal":"Scientific reports"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nifurpirinol, also known as Furacin, is a small molecule antimicrobial agent developed by Pfizer. It is classified as a nifurpirinol, a class of compounds with antimicrobial properties. The exact target of nifurpirinol is unknown, but it is used to treat various infections, including those caused by bacteria and fungi. Nifurpirinol is not FDA-approved for any indications, and its commercial status is unclear. As a result, there is limited information available on its safety profile and pharmacokinetic properties.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}